Protein Alignment bon and Trim66

DIOPT Version :10

• Sequence 1: NP_001262765.1
• Gene: bon / 44235
• FlyBaseID: FBgn0023097
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: NP_001178768.1
• Gene: Trim66 / 361623
• RGDID: 1595847
• Length: 1348
• Species: Rattus norvegicus
• Alignment Length: 1384
• Identity: 313/1384 - (22%)
• Similarity: 478/1384 - (34%)
• Gaps: 436/1384 - (31%)

  Fly    97 KLLECLHVACAQCVSTKFSELDR------SLP-PLIHCPVCDNASQQEFIVDNQFLIEQCTAGDS 154
            :||.|.|:.|..|......||..      :.| .||.||.|........:.::.||  ||.:
  Rat    41 RLLPCQHLLCKACFQGCLQELVHVPRAHWTAPGELISCPGCQRIYLTRDVTEHIFL--QCFS--- 100

  Fly   155 GDGVGLLGLTGEGQKSSAAASIQCSSCSDGAVATSWCVDCSEYICDSCVQAHQRLKITKDHTIKP 219
                       .|:.:.|.:   ||.|.:...|...|..|:.::|.||.:.|:       |...|
  Rat   101 -----------PGKPTMARS---CSECKEKRAAHILCTYCNRWLCSSCTEEHR-------HVPAP 144

  Fly   220 KDEANNEQLAGAAGV-----DKLHMCQLHPQEKLSLFCETCDKLTCRDCQLSDHRDHKYKFAHEI 279
            ..........|::||     |....|.||..|.|.|||||||.|||..|.:.:|::|:.:...|:
  Rat   145 GGPLFARAQKGSSGVNGGSGDFALYCPLHTHEVLKLFCETCDVLTCHSCLMVEHKEHRCRHVEEV 209

  Fly   280 ATESRQALSTLVSEINYKRFLLSSATKVIDDRQQLIHDKKKDLIKEITAMAVKITNTVNTRGKQL 344
            ....|..|.::.:::.:|:..|.::.|.|:||...:..:.:.:..:|....:.:.|.:|.:...|
  Rat   210 LQNQRMLLESVTTQVAHKKSSLQTSAKQIEDRIFEVKHQHRKVENQIKMAKMVLMNELNKQANGL 274

  Fly   345 IMRLNEVCDSKLKVLVEKKETLQLLSDNTDHCIDFMQNALEKGSDFAILSSKKSLVRHLQKL--- 406
            |..|..:.:.:.:.|.::.:::.:|:...:|..:|:..|:...:....|.||:.:|..:|:|
  Rat   275 IEELEGITNERKRKLEQQLQSIMVLNRQFEHVQNFINWAVCSKTSVPFLFSKELIVFQMQRLLET 339

  Fly   407 KCQRADIPNPEIP--VRIQVQLNQVSDLQKVISQLGIIIVDGKPY-------------------- 449
            .|.    .:|..|  :|...:.|..:   |.::.||.|..:|...
  Rat   340 SCN----TDPGSPWSIRFTWEPNFWT---KQLASLGCITTEGGQLTRADAAPAAYGNLQGQSSFY 397

  Fly   450 ------------------------------------PPTPSPNG-TPQPQ-HPP---RQP----- 468
                                                |.:||..| .|.|. ||.   |||
  Rat   398 QSHQAPMAQQEALSHPSHKFQSPALCSSSVCCSHCSPVSPSLKGQVPPPSIHPVHSFRQPSEMVP 462

  Fly   469 -----------------PSPNMAPP--LRPGLPPGMPA---GLSPNG------------PP--VN 497
                             |:.:..||  |:|.|.|..||   |.|...            ||  |.
  Rat   463 HQLGSLQCPTLLPREKEPACSPHPPKLLQPWLEPQPPAEQEGTSQRPGQQLVSQPVCIVPPQDVQ 527

  Fly   498 FGPQNGPPLYSNAAQQQFNN---LSMSRSFPGDGSGKVRFGGMPPVGMQRHGQP------HVSSS 553
            .|....|.:.:.:.|.|..:   |.:|. |......:......||:...:|..|      |::||
  Rat   528 PGAHAQPTIQTPSIQVQLGHHQKLKLSH-FQQQPQQQPPPPPPPPLPAPQHAPPPLPPSQHLASS 591

  Fly   554 TH--------PQNMDI------------SLRGLLNNQAAQSPNAHMAFNGPPSY----------- 587
            .|        .||:||            .|..||.   ||.|:..::....|.:
  Rat   592 QHESPPGPACSQNVDIMHHKFELEEMQKDLELLLQ---AQQPSLQLSQTKSPQHLQQTIVGQINY 653

  Fly   588 ----------------------PGGPQGAPAPA-----------HQPMGPQMRPHFMPGQQGFSQ 619
                                  |...:| |.||           .|..|.: .||..|.....||
  Rat   654 IVRQPAPVQSQSQEDTLQVTEEPPASEG-PKPALPVDKNTATSLSQTSGEE-TPHSAPSVDSSSQ 716

  Fly   620 GGGPGGGPRDA------NFMN------SNARFQ-------------------------------- 640
            ...|....:.|      .|.|      |:.|..
  Rat   717 HSSPNVVRKHATSVSIMGFSNTVEMELSSTRLARTIEPQIHRVSSLTAAPTHTIPSLLSGPSQTV 781

  Fly   641 SQYQRMANHAQQAAAAAAMAGAAGGGGGQIPSPGALQRP-QMMSNPMQNVSAMQNSLGFHGSQAG 704
            |....::|||..:..|:.:.          |.|..::.. |...||..:.|....||....||||
  Rat   782 SSLMSVSNHAMPSLTASHLQ----------PVPNLVRGAFQSTPNPRGDSSQAITSLASTHSQAG 836

  Fly   705 --FNTGPPQTSPQLGG---GGMHSLAKWHI------------------PQSAQQSN----MCS-- 740
              ..:|..|..|.|..   .||..::..|:                  |:...:|:    :|.
  Rat   837 PSLVSGHTQAVPSLATCPLQGMPPVSDLHVEPRSVSSPGSGPTAESLGPRDGAESSLGNALCKLE 901

  Fly   741 -----------QQGPLLP-------FANGRQTSENFKISLKSPNTLKNSTPPSLGGGGAGHQGHG 787
                       .|||..|       .|...:..|...:|:|.|     ...|.:....|..|..
  Rat   902 SEDGTRFTDSVGQGPTAPSLDDPKDLAIPSELEEPINLSVKKP-----LLAPVISTAAAPQQSR- 960

  Fly   788 NGSSSAQLNAAALGLGPAVSILSNVTSTNPKTP-----------SPSTHENTKDFTEPIDKVR-- 839
            |..........||.|....:..|:...:.||.|           :||..       .|:.|::
  Rat   961 NLKEYENFEQGALELDTKENSNSSAIGSEPKIPYVRLERLKICAAPSGE-------MPVFKLKPQ 1018

  Fly   840 ----DDSINDLIATIAKLDSNGVQVLPE-----------GRTKTTSPQVHSSTDLSNTQEVNNKN 889
                |.|...:|...|:..|..::|...           |..|.|...:.....|    ||:..:
  Rat  1019 KNSQDGSFLLVIECGAESSSMSIKVSQSSLSDANQGPGLGGRKVTVTSLTGQRPL----EVDGTS 1079

  Fly   890 EQ-----------KDDP----NEDWCAVCLDGGELMCCDKCPKVFHQNCHIPAISSLPDESESWQ 939
            ::           |..|    |||:||||::||||:|||:||||:|.:||:||:.|.|  ...|.
  Rat  1080 DEHRLIPRTLGAKKCIPAPIENEDFCAVCINGGELLCCDRCPKVYHLSCHVPALLSFP--GGEWV 1142

  Fly   940 CLLCVNIKELTK------TEGSEKSSSG-----ELSALELRILQRICLELYCQYEQSLNFREPES 993
            |.||   :.||:      .|.:..|..|     .||..:.:..:::.|.|.|. ..||.|.||.|
  Rat  1143 CTLC---RSLTQPEMEYDCENARYSHPGVRALPGLSMYDQKKCEKLVLSLCCN-SLSLPFHEPVS 1203

  Fly   994 PANTSYYEIVSSPMSLDVIRTRLDPSSPNHYKDIAGFVSDVRLIFSNTYLFYQEDTKTYSNAKYL 1058
            |....||:|:..||.|.:||.:|....|.||......||||||:|.|...|...|::.....:.|
  Rat  1204 PLARHYYQIIKRPMDLSIIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAKFNYPDSEVAEAGRCL 1268

  Fly  1059 ENFFEEQLAKWLPQFEGTKPQGKRNTSNSPALLGVNATGSPSP------IENGRKSCGSASLGDS 1117
            |.|||..|.:..|.....:||  :..|:|..:.|.:...:|..      ::.|
  Rat  1269 EVFFEGWLKEIYPDKCFAQPQ--QEDSDSEDVSGESGCSTPQGFPWPPYMQEG------------ 1319

  Fly  1118 DGACLPAKRARRSAHEXNE 1136
                :..||.||  |..||
  Rat  1320 ----IQPKRRRR--HMENE 1332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bon	NP_001262765.1	RING_Ubox	<92..130	CDD:473075	13/39 (33%)
		Bbox1_TIF1	177..220	CDD:380863	11/42 (26%)
		Bbox2_TIF1_C-VI	238..278	CDD:380833	18/39 (46%)
		BBC	284..409	CDD:128778	25/127 (20%)
		Med15	486..>743	CDD:312941	78/431 (18%)
		PHD_TIF1_like	899..943	CDD:277016	24/43 (56%)
		Bromo_tif1_like	963..1072	CDD:99934	40/108 (37%)
Trim66	NP_001178768.1	Bbox1_TRIM66	109..145	CDD:380869	11/45 (24%)
		Bbox2_TRIM66-like	168..210	CDD:380852	19/41 (46%)
		BBC	213..338	CDD:128778	25/124 (20%)
		PAT1	<382..>499	CDD:401645	18/116 (16%)
		PHD_SF	1101..1149	CDD:473978	29/52 (56%)
		Bromo_tif1_like	1174..1282	CDD:99934	40/108 (37%)