DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bon and Trim66

DIOPT Version :9

Sequence 1:	NP_001262765.1	Gene:	bon / 44235	FlyBaseID:	FBgn0023097	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	NP_001164383.1	Gene:	Trim66 / 330627	MGIID:	2152406	Length:	1344	Species:	Mus musculus

Alignment Length:	1435	Identity:	324/1435 - (22%)
Similarity:	499/1435 - (34%)	Gaps:	473/1435 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    58 SNPCDSAEKRSESNSSASAKFTLFKCVYCAQLLGSNDRPKLLECLHVACAQCVSTKFSEL---DR 119
            |.|..|.::|.|:.:..        |..|.:.|.: :..:||.|.|:.|..|......||   .|
Mouse    11 SQPHCSTDERVEALAPT--------CSMCGRDLQA-EGSRLLPCQHLLCKDCYQGFMQELGHATR 66

  Fly   120 SLP-PLIHCPVCDNASQQEFIVDNQFLIEQCTAGDSGDGVGLLGLTGEGQKSSAAASIQCSSCSD 183
            :.| .||.||.|........:.::.||  ||.:               ..|.:.|.:  ||.|.:
Mouse    67 AYPGKLISCPGCQRVYLTRDVTEHIFL--QCFS---------------PVKPTMARN--CSECKE 112

  Fly   184 GAVATSWCVDCSEYICDSCVQAHQRLKITKDHTIKPKDEANNEQLAGAAGV-----DKLHMCQLH 243
            ...|...|..|:.::|.||.:.|:       |...|..........|::||     |....|.||
Mouse   113 KRAAHILCTYCNRWLCSSCTEEHR-------HVPAPGGPLFARAQKGSSGVNGGSGDFALYCPLH 170

  Fly   244 PQEKLSLFCETCDKLTCRDCQLSDHRDHKYKFAHEIATESRQALSTLVSEINYKRFLLSSATKVI 308
            .||.|.|||||||.|||..|.:.:|::|:.:...|:....|..|.::.|::.:|:..|.::.|.|
Mouse   171 TQEVLKLFCETCDVLTCHSCLMVEHKEHRCRHVEEVLQNQRMLLESVTSQVAHKKSSLQTSAKQI 235

  Fly   309 DDRQQLIHDKKKDLIKEITAMAVKITNTVNTRGKQLIMRLNEVCDSKLKVLVEKKETLQLLSDNT 373
            :||...:..:.:.:..:|....:.:.|.:|.:...||..|..:.:.:.:.|.::.:::.:|:...
Mouse   236 EDRIFEVKHQHRKVENQIKMAKMVLMNELNKQANGLIEELEGITNERKRKLEQQLQSIMVLNRQF 300

  Fly   374 DHCIDFMQNALEKGSDFAILSSKKSLVRHLQKLKCQRADI-PNPEIPVRIQVQLNQVSDLQKVIS 437
            :|..:|:..|:...|....|.||:.:|..:|:|...|.:. |.....:|...:.|..:   |.::
Mouse   301 EHVQNFINWAVCSKSSVPFLFSKELIVFQMQRLLETRCNTDPGSPWSIRFTWEPNFWT---KQLA 362

  Fly   438 QLGIIIVDG-------------------------------------------------------- 446
            .||.|..:|
Mouse   363 SLGCITTEGGQLTRADAAAASYGSLQGQPSFYQSHQAPMAQQEALSHPSHKFQSPALCSSSVCCS 427

  Fly   447 --KPYPPT-----PSPNGTP-----QPQ--------------------------HPPR------- 466
              .|..|:     |.|:..|     ||.                          |||:
Mouse   428 HCSPVSPSLKGQVPPPSIHPAHSFRQPSEMVPHQLGSLQCSTLLPREKELACSPHPPKLMQPWLE 492

  Fly   467 -QPPSPNMAPPLRPG----------LPP----------------------------------GMP 486
             |||:...:...|||          :||                                  ..|
Mouse   493 PQPPAEQESTSQRPGPQLVSQPVCIVPPQDVQPGAHAQPTIQTPSIQVQLGHHQKLKLSHFQQQP 557

  Fly   487 AGLSPNGPPVNFGPQNGPPLYSNAAQQQFNNLSMSRSFPGDGSGKVRFGGMPPVGMQRH------ 545
            ....|..||....||:.||   .....|....|...|.||....:       .|.:..|
Mouse   558 QQQPPPPPPPPPPPQHAPP---PLPPSQHLASSQHESPPGPACSQ-------NVDIMHHKFELEE 612

  Fly   546 -----------GQP--HVSSSTHPQNMDISLRGLLN---NQAA----QSPNAHMAFNGPPSYPGG 590
                       .||  .:|.:..||::..::.|.:|   .|.|    ||....:.....|..|.|
Mouse   613 MQKDLELLLQAQQPSLQLSQTKSPQHLQQTIVGQINYIVRQPAPVQSQSQEETLQVTEEPPAPEG 677

  Fly   591 PQGA-------PAPAHQPMGPQMRPHFMPGQQGFSQGGGPGGGPRDA------NFMN------SN 636
            |:.|       .||..|..|.: .||.:|...|.||...|....:.|      .|.|      |:
Mouse   678 PKPALPVDKNTAAPLPQTSGEE-TPHSVPPVDGTSQHSSPNVVRKHATSVSIMGFSNTVEMELSS 741

  Fly   637 ARFQSQYQRMANHAQQAAAAAAMAGAAGGGGGQIPSPGALQRPQMMSNPMQNVSAM--------- 692
            .|.....:...:......||....         |||        ::|.|.|.||::
Mouse   742 TRLARTIEPQIHRVSSLTAAPTHT---------IPS--------LLSGPPQTVSSLMSVSNHAMP 789

  Fly   693 ------------------QNSLGFHG--SQA--GFNTGPPQTSPQLGGGGMHSLAKWHIPQSAQQ 735
                              |::....|  |||  |..:...|..|.|..|  |:       |:|..
Mouse   790 SLTASHLQPVPNLVRGTFQSTSNLRGDSSQAITGLASNHSQAGPSLMSG--HT-------QAAPS 845

  Fly   736 SNMCSQQGPLLPFANGRQTSENFKISLKSPNTLKNSTPPSLGGGGAGHQGHGNGSSSAQLNAA-- 798
            ...|..||  :|..:.......   |:.||.:          |..|...|..:|:.|:..||.
Mouse   846 LATCPLQG--MPPVSDVHVEPR---SVSSPGS----------GPAAESLGTRDGAESSLGNALCK 895

  Fly   799 -----------ALGLGPAVSILS----------------------------NVTSTNPKTPSPST 824
                       ::|.||..|.|.                            |.::...:..:|..
Mouse   896 MESEDCTRFSDSVGQGPTASSLDGPKDLAIPSELEEPINLSVKKPFLAPVINTSTALQQYRNPKE 960

  Fly   825 HEN---------TKD-------FTEP-IDKVRDDSINDLIATIAKL------------DSNGVQV 860
            :||         ||:       .:|| |..||.:.:....|:..::            |.|.:.|
Mouse   961 YENFEQGALELDTKENSDIRAISSEPKIPYVRLERLKICAASSGEMPVFKLKPQKNSQDGNFLLV 1025

  Fly   861 LPEGRTKTTSPQVHSS--------------------TDLS--NTQEVNNKNEQ-----------K 892
            :..| |:::|..:..|                    |.|:  ..|||.:.:|:           |
Mouse  1026 IECG-TESSSMSIKVSQNSLPDASQGPGLGGRKVTVTSLTGQQPQEVESTSEEHRLIPRAPGAKK 1089

  Fly   893 DDP----NEDWCAVCLDGGELMCCDKCPKVFHQNCHIPAISSLPDESESWQCLLCVNIKELTKTE 953
            :.|    |||:||||::||||:|||:||||:|.:||:||:.|.|  ...|.|.||   :.||:.|
Mouse  1090 NTPAPIENEDFCAVCINGGELLCCDRCPKVYHLSCHVPALLSFP--GGEWVCTLC---RSLTQPE 1149

  Fly   954 ---GSEKSSSGE--------LSALELRILQRICLELYCQYEQSLNFREPESPANTSYYEIVSSPM 1007
               ..|.:..|.        ||..:.:..:::.|.|.|. ..||.|.||.||....||:|:..||
Mouse  1150 MEYDCENARYGHPGVRVLPGLSMYDQKKCEKLVLSLCCN-SLSLPFHEPVSPLARHYYQIIKRPM 1213

  Fly  1008 SLDVIRTRLDPSSPNHYKDIAGFVSDVRLIFSNTYLFYQEDTKTYSNAKYLENFFEEQLAKWLPQ 1072
            .|.:||.:|....|.||......||||||:|.|...|...|::.....:.||.|||..|.:..|.
Mouse  1214 DLSIIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAKFNYPDSEVAEAGRCLEVFFEGWLKEIYPD 1278

  Fly  1073 FEGTKPQGKRNTSNSPALLGVNATGSPSP------IENGRKSCGSASLGDSDGACLPAKRARRSA 1131
            ....:||  :..|:|..:.|.:...:|..      ::.|                :..||.||
Mouse  1279 KCFAQPQ--QEDSDSEDVSGESGCSTPQGFPWPPYMQEG----------------IQPKRRRR-- 1323

  Fly  1132 HEXNE 1136
            |..||
Mouse  1324 HMENE 1328

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bon	NP_001262765.1	zf-RING_5	82..130	CDD:291308	17/51 (33%)
		BBOX	239..275	CDD:237988	19/35 (54%)
		BBC	284..409	CDD:128778	27/124 (22%)
		PHD_TIF1_like	899..943	CDD:277016	24/43 (56%)
		Bromo_tif1_like	963..1072	CDD:99934	40/108 (37%)
Trim66	NP_001164383.1	zf-B_box	166..201	CDD:279037	19/34 (56%)
		BBC	210..335	CDD:128778	27/124 (22%)
		PHD_SF	1097..1145	CDD:304600	29/52 (56%)
		Bromo_tif1_like	1170..1278	CDD:99934	40/108 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	79	1.000	Domainoid score	I8651
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	342	1.000	Inparanoid score	I2324
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330513at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	4.020