DRSC/TRiP Functional Genomics Resources

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Protein Alignment bon and Trim66

DIOPT Version :10

Sequence 1:NP_001262765.1 Gene:bon / 44235 FlyBaseID:FBgn0023097 Length:1207 Species:Drosophila melanogaster
Sequence 2:NP_001164383.1 Gene:Trim66 / 330627 MGIID:2152406 Length:1344 Species:Mus musculus


Alignment Length:1435 Identity:324/1435 - (22%)
Similarity:499/1435 - (34%) Gaps:473/1435 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    58 SNPCDSAEKRSESNSSASAKFTLFKCVYCAQLLGSNDRPKLLECLHVACAQCVSTKFSEL---DR 119
            |.|..|.::|.|:.:..        |..|.:.|.: :..:||.|.|:.|..|......||   .|
Mouse    11 SQPHCSTDERVEALAPT--------CSMCGRDLQA-EGSRLLPCQHLLCKDCYQGFMQELGHATR 66

  Fly   120 SLP-PLIHCPVCDNASQQEFIVDNQFLIEQCTAGDSGDGVGLLGLTGEGQKSSAAASIQCSSCSD 183
            :.| .||.||.|........:.::.||  ||.:               ..|.:.|.:  ||.|.:
Mouse    67 AYPGKLISCPGCQRVYLTRDVTEHIFL--QCFS---------------PVKPTMARN--CSECKE 112

  Fly   184 GAVATSWCVDCSEYICDSCVQAHQRLKITKDHTIKPKDEANNEQLAGAAGV-----DKLHMCQLH 243
            ...|...|..|:.::|.||.:.|:       |...|..........|::||     |....|.||
Mouse   113 KRAAHILCTYCNRWLCSSCTEEHR-------HVPAPGGPLFARAQKGSSGVNGGSGDFALYCPLH 170

  Fly   244 PQEKLSLFCETCDKLTCRDCQLSDHRDHKYKFAHEIATESRQALSTLVSEINYKRFLLSSATKVI 308
            .||.|.|||||||.|||..|.:.:|::|:.:...|:....|..|.::.|::.:|:..|.::.|.|
Mouse   171 TQEVLKLFCETCDVLTCHSCLMVEHKEHRCRHVEEVLQNQRMLLESVTSQVAHKKSSLQTSAKQI 235

  Fly   309 DDRQQLIHDKKKDLIKEITAMAVKITNTVNTRGKQLIMRLNEVCDSKLKVLVEKKETLQLLSDNT 373
            :||...:..:.:.:..:|....:.:.|.:|.:...||..|..:.:.:.:.|.::.:::.:|:...
Mouse   236 EDRIFEVKHQHRKVENQIKMAKMVLMNELNKQANGLIEELEGITNERKRKLEQQLQSIMVLNRQF 300

  Fly   374 DHCIDFMQNALEKGSDFAILSSKKSLVRHLQKLKCQRADI-PNPEIPVRIQVQLNQVSDLQKVIS 437
            :|..:|:..|:...|....|.||:.:|..:|:|...|.:. |.....:|...:.|..:   |.::
Mouse   301 EHVQNFINWAVCSKSSVPFLFSKELIVFQMQRLLETRCNTDPGSPWSIRFTWEPNFWT---KQLA 362

  Fly   438 QLGIIIVDG-------------------------------------------------------- 446
            .||.|..:|                                                        
Mouse   363 SLGCITTEGGQLTRADAAAASYGSLQGQPSFYQSHQAPMAQQEALSHPSHKFQSPALCSSSVCCS 427

  Fly   447 --KPYPPT-----PSPNGTP-----QPQ--------------------------HPPR------- 466
              .|..|:     |.|:..|     ||.                          |||:       
Mouse   428 HCSPVSPSLKGQVPPPSIHPAHSFRQPSEMVPHQLGSLQCSTLLPREKELACSPHPPKLMQPWLE 492

  Fly   467 -QPPSPNMAPPLRPG----------LPP----------------------------------GMP 486
             |||:...:...|||          :||                                  ..|
Mouse   493 PQPPAEQESTSQRPGPQLVSQPVCIVPPQDVQPGAHAQPTIQTPSIQVQLGHHQKLKLSHFQQQP 557

  Fly   487 AGLSPNGPPVNFGPQNGPPLYSNAAQQQFNNLSMSRSFPGDGSGKVRFGGMPPVGMQRH------ 545
            ....|..||....||:.||   .....|....|...|.||....:       .|.:..|      
Mouse   558 QQQPPPPPPPPPPPQHAPP---PLPPSQHLASSQHESPPGPACSQ-------NVDIMHHKFELEE 612

  Fly   546 -----------GQP--HVSSSTHPQNMDISLRGLLN---NQAA----QSPNAHMAFNGPPSYPGG 590
                       .||  .:|.:..||::..::.|.:|   .|.|    ||....:.....|..|.|
Mouse   613 MQKDLELLLQAQQPSLQLSQTKSPQHLQQTIVGQINYIVRQPAPVQSQSQEETLQVTEEPPAPEG 677

  Fly   591 PQGA-------PAPAHQPMGPQMRPHFMPGQQGFSQGGGPGGGPRDA------NFMN------SN 636
            |:.|       .||..|..|.: .||.:|...|.||...|....:.|      .|.|      |:
Mouse   678 PKPALPVDKNTAAPLPQTSGEE-TPHSVPPVDGTSQHSSPNVVRKHATSVSIMGFSNTVEMELSS 741

  Fly   637 ARFQSQYQRMANHAQQAAAAAAMAGAAGGGGGQIPSPGALQRPQMMSNPMQNVSAM--------- 692
            .|.....:...:......||....         |||        ::|.|.|.||::         
Mouse   742 TRLARTIEPQIHRVSSLTAAPTHT---------IPS--------LLSGPPQTVSSLMSVSNHAMP 789

  Fly   693 ------------------QNSLGFHG--SQA--GFNTGPPQTSPQLGGGGMHSLAKWHIPQSAQQ 735
                              |::....|  |||  |..:...|..|.|..|  |:       |:|..
Mouse   790 SLTASHLQPVPNLVRGTFQSTSNLRGDSSQAITGLASNHSQAGPSLMSG--HT-------QAAPS 845

  Fly   736 SNMCSQQGPLLPFANGRQTSENFKISLKSPNTLKNSTPPSLGGGGAGHQGHGNGSSSAQLNAA-- 798
            ...|..||  :|..:.......   |:.||.:          |..|...|..:|:.|:..||.  
Mouse   846 LATCPLQG--MPPVSDVHVEPR---SVSSPGS----------GPAAESLGTRDGAESSLGNALCK 895

  Fly   799 -----------ALGLGPAVSILS----------------------------NVTSTNPKTPSPST 824
                       ::|.||..|.|.                            |.::...:..:|..
Mouse   896 MESEDCTRFSDSVGQGPTASSLDGPKDLAIPSELEEPINLSVKKPFLAPVINTSTALQQYRNPKE 960

  Fly   825 HEN---------TKD-------FTEP-IDKVRDDSINDLIATIAKL------------DSNGVQV 860
            :||         ||:       .:|| |..||.:.:....|:..::            |.|.:.|
Mouse   961 YENFEQGALELDTKENSDIRAISSEPKIPYVRLERLKICAASSGEMPVFKLKPQKNSQDGNFLLV 1025

  Fly   861 LPEGRTKTTSPQVHSS--------------------TDLS--NTQEVNNKNEQ-----------K 892
            :..| |:::|..:..|                    |.|:  ..|||.:.:|:           |
Mouse  1026 IECG-TESSSMSIKVSQNSLPDASQGPGLGGRKVTVTSLTGQQPQEVESTSEEHRLIPRAPGAKK 1089

  Fly   893 DDP----NEDWCAVCLDGGELMCCDKCPKVFHQNCHIPAISSLPDESESWQCLLCVNIKELTKTE 953
            :.|    |||:||||::||||:|||:||||:|.:||:||:.|.|  ...|.|.||   :.||:.|
Mouse  1090 NTPAPIENEDFCAVCINGGELLCCDRCPKVYHLSCHVPALLSFP--GGEWVCTLC---RSLTQPE 1149

  Fly   954 ---GSEKSSSGE--------LSALELRILQRICLELYCQYEQSLNFREPESPANTSYYEIVSSPM 1007
               ..|.:..|.        ||..:.:..:::.|.|.|. ..||.|.||.||....||:|:..||
Mouse  1150 MEYDCENARYGHPGVRVLPGLSMYDQKKCEKLVLSLCCN-SLSLPFHEPVSPLARHYYQIIKRPM 1213

  Fly  1008 SLDVIRTRLDPSSPNHYKDIAGFVSDVRLIFSNTYLFYQEDTKTYSNAKYLENFFEEQLAKWLPQ 1072
            .|.:||.:|....|.||......||||||:|.|...|...|::.....:.||.|||..|.:..|.
Mouse  1214 DLSIIRRKLQKKDPAHYTTPEEVVSDVRLMFWNCAKFNYPDSEVAEAGRCLEVFFEGWLKEIYPD 1278

  Fly  1073 FEGTKPQGKRNTSNSPALLGVNATGSPSP------IENGRKSCGSASLGDSDGACLPAKRARRSA 1131
            ....:||  :..|:|..:.|.:...:|..      ::.|                :..||.||  
Mouse  1279 KCFAQPQ--QEDSDSEDVSGESGCSTPQGFPWPPYMQEG----------------IQPKRRRR-- 1323

  Fly  1132 HEXNE 1136
            |. ||
Mouse  1324 HMENE 1328

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
bonNP_001262765.1 RING_Ubox <92..130 CDD:473075 14/41 (34%)
Bbox1_TIF1 177..220 CDD:380863 11/42 (26%)
Bbox2_TIF1_C-VI 238..278 CDD:380833 19/39 (49%)
BBC 284..409 CDD:128778 27/124 (22%)
Med15 486..>743 CDD:312941 71/332 (21%)
PHD_TIF1_like 899..943 CDD:277016 24/43 (56%)
Bromo_tif1_like 963..1072 CDD:99934 40/108 (37%)
Trim66NP_001164383.1 RING_Ubox 27..78 CDD:473075 17/59 (29%)
Bbox1_TRIM66 106..142 CDD:380869 11/44 (25%)
Bbox2_TRIM66-like 165..207 CDD:380852 20/41 (49%)
BBC 210..335 CDD:128778 27/124 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 478..513 9/34 (26%)
PHA03369 <481..716 CDD:223061 52/245 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 541..600 13/68 (19%)
PRK12757 <610..>701 CDD:237191 20/91 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 655..719 19/64 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 861..888 7/39 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 903..924 5/20 (25%)
PxVxL motif 989..993 1/3 (33%)
PHD_SF 1097..1145 CDD:473978 29/52 (56%)
Bromo_tif1_like 1170..1278 CDD:99934 40/108 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1284..1344 14/65 (22%)

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