DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bon and trim33l

DIOPT Version :9

Sequence 1:	NP_001262765.1	Gene:	bon / 44235	FlyBaseID:	FBgn0023097	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	XP_005158134.1	Gene:	trim33l / 327484	ZFINID:	ZDB-GENE-030131-5695	Length:	1293	Species:	Danio rerio

Alignment Length:	1358	Identity:	276/1358 - (20%)
Similarity:	452/1358 - (33%)	Gaps:	386/1358 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 SASAKFTLFK-----CVYCAQLLGSNDRPKLLECLHVACAQC---VSTKFSELDRSLPPLIHCPV 129
            |||.:..|.|     |..|...|..:..||||.|||..|..|   :.|..|..|        ||.
Zfish    10 SASPRPDLQKAVCGTCAACKGHLNDSTEPKLLPCLHTVCNTCLTKICTDGSSQD--------CPS 66

  Fly   130 CDNASQQEFIVDNQFLIEQCTAGDSGDGVGLLGLTGEGQKSSAAASIQCSSCSDGAVATSWCVDC 194
            |    .|.|.:..   :.:|...:.         ..:..|:.     :|..|.:..| :.|||.|
Zfish    67 C----AQSFGLSE---VTECAIFED---------LSDNNKAP-----KCGGCEENEV-SGWCVQC 109

  Fly   195 SEYICDSCVQAHQRLKITKDHTIKPKDEANNEQLAGAAGVDKLHMCQLHPQEKLSLFCETCDKLT 259
            .|.:|..||.||.|:|:|:||.:.||..        ..|..:...|.||.||.|..||..|::||
Zfish   110 EEALCLDCVTAHHRVKVTRDHEVMPKKP--------PTGWIQRRRCPLHSQESLRFFCLVCEELT 166

  Fly   260 CRDCQLSDHRDHKYKFAHEIATESRQALSTLVSEINYKRFLLSSATKVIDDRQQLIHDKKKDLIK 324
            |:||||..||.|.:....|.....:|.:::|:..|..::..:|.:..:::.|.|.| :..|.|.|
Zfish   167 CKDCQLITHRGHSFVNQEEAVESQKQQMNSLLDSIRRQKGTISHSLLLLEARLQDI-EHVKMLTK 230

  Fly   325 EITAMAV-KITNTVNTRGKQLIMRLNEVCDSKLKVLVEKKETLQLLSDNTDHCIDFMQNALEKGS 388
            ::...:| ||.:::..:..|::..:..|...:::||:|:|.:|..|....|:..||: :.:::..
Zfish   231 KLLIQSVHKIYHSMVLKASQILKDIQAVFAEEVRVLLERKSSLSRLEGCQDYIADFI-DKIQRTQ 294

  Fly   389 DFAILSSKKSLVRHLQKLKCQRADIPNPEIPVRIQVQLNQVSDLQKVISQLGIIIVD-------- 445
            ...:|..||.:...::.|..:....|...|.:.|::|    .||.:.|...|.:.:.
Zfish   295 GHCLLVYKKRIETQVKMLLSRETCTPESMIKLHIEIQ----KDLCQHILNFGFVRITKNFVPFTS 355

  Fly   446 ------------------------------------GKPYPPTPSPNGTPQPQHPPRQ------- 467
                                                .:..|..|:.:....|.|...|
Zfish   356 ERTQYIQTNPVSVESLNPNSMETATNVGHAMASSSVNEQIPGDPATSSQTAPNHQILQSILQLSR 420

  Fly   468 ------PPSPNMAPPLRPGLP-----------PGMPAGLSPNGPPVNFGPQN---GPPLYSN--- 509
                  .|.||.....:|.|.           ...|..:......|..|...   .|.::|.
Zfish   421 SNQATTQPQPNHGTLFQPDLSNVRYSDSQSSCSSSPLSVQAQSHEVMSGQSKHAYSPSVHSQHHL 485

  Fly   510 -AAQQ---QFNNLSMSR----------------------------SFPGDGSGKVRFGGMP---- 538
             ::||   :.|:.:..|                            |.|......|:....|
Zfish   486 PSSQQTKTKCNSKTAKRGNTWTLHYYSDMPNQTIPRIIQTPAPTHSIPASKKTPVQTHPNPTNNQ 550

  Fly   539 ---PV-GMQRHGQPHV-------------------SSSTHP---QNMDISLRGL-LNNQAAQSPN 576
               || .|..|.|..:                   |..|||   .|..:.|:.: .|.|:....:
Zfish   551 ILTPVHPMLAHNQTTIPVYPIQGNNQIPIASNNQTSIPTHPIPGSNQPLLLQQIPANTQSTLLTH 615

  Fly   577 AHMAFNGPPSYPGG--------PQGAP--------APAHQ-PMGPQMRP---------------H 609
            |.:..|..|..|.|        .|..|        .|.|. |...|.:|               |
Zfish   616 AVLVNNLSPVVPYGLTANDQTLVQTQPILANNQTSVPTHAIPFNNQRKPLPQPITDNNKSLVLTH 680

  Fly   610 FMPGQQGFSQGGGPGGGPRDANFMNSNARFQSQ-------YQRMANHAQQAAAA----AAMAGAA 663
            .:|..........|......|..:..:.:|.:|       ...:.:..|....|    |...||.
Zfish   681 PIPNNNQTPVLMPPIQANNQAATLTHSVQFNNQTPGLTHPVSNIQSDVQTLIVAHPIQAGFLGAV 745

  Fly   664 GGGGGQIPSPGALQRPQMMSNPMQNVSAMQN--SLGFHGS-------QAGFNTGPPQTSPQ---L 716
            .|...| |:........:.:.|:..|:|:.|  |.|....       .:.||..|..:||.   |
Zfish   746 HGFAAQ-PNVPLTILSTVNALPLNEVTAVSNVHSTGTSNDVMNHCPINSAFNVTPSGSSPHANPL 809

  Fly   717 GGGGMHSLAKWHIPQSAQQSNMCSQQGPL--LPFANGRQTSENFKISL------KSP-------- 765
            ....:....:.:||..|...:.|.|:..:  ..|.....:..|...|.      .||
Zfish   810 CSDPISGSNRTNIPVKALADSACDQEAGMSSTSFTYADYSESNLPTSTVSDPRESSPLSPDLCFA 874

  Fly   766 --NTLKNSTPPSLGGGGAGH------QGHGNGSSSAQLNAAALGLGPAVSILSNVTSTNPKTPSP 822
              ::|..:|...:....||.      .|..:.|:........| |....:.::::.|.|..||..
Zfish   875 VLDSLSTTTKKCVRQDKAGQSTTECDSGSKHWSADMPTTFRQL-LETTCTPVNSIDSRNATTPVG 938

  Fly   823 ST----------------------------HENTKDFTEPIDKVR---DDSINDLIATIAKLDSN 856
            ||                            .:|.|:....:.:.:   .:....|..::.:|.
Zfish   939 STPCGSSEDITGKSVSNGKTIQSCFDHSEGEKNEKESAATLKRFKTQLKEFRRSLCVSLVRLP-- 1001

  Fly   857 GVQVLPEGRTKTTSPQVHSSTDLSNTQEVNNKNEQKDDPNEDW---------------------- 899
             |.:.|.|.   ..|:.|.:|| |:|..:..:..|..:..:.|
Zfish  1002 -VSLPPHGH---PLPEFHLTTD-SSTDHILVQESQGGEIKQVWRWHDGPVASRASSCSTSQMSDI 1061

  Fly   900 ----------CAVCLDGGELMCCDKCPKVFHQNCHIPAISSLPDESESWQCLLCVNIKELTKTEG 954
                      |.||...|..:.|.||...||.:||||.|.:.|  .|.|.||||.::.|....:.
Zfish  1062 DSSPASDVQFCVVCQSAGASLLCAKCGSAFHSDCHIPPIFTKP--REDWVCLLCQDVSETLMIDS 1124

  Fly   955 SEKSSSGELSALELRILQRICLELYCQYEQSLNFREPESPANTSYYEIVSSPMSLDVIRTRLDPS 1019
            .|:..:..||..:.|..:::.|.|.|.....|.:...::.:.|:.:         |:|..||..:
Zfish  1125 GEEMKTTGLSLQDQRRCEKLLLGLQCDENMGLLYSVTKNHSKTAEF---------DIILGRLQGN 1180

  Fly  1020 SPNHYKDIAGFVSDVRLIFSNTYLFYQEDTKTYSNAKYLENFFEEQLAKWLPQFEGTKPQGK--R 1082
            ....|:..|..||||..:|.  .||.:.:.|:      |....::...:.|.|..||.....  :
Zfish  1181 RKPPYRTAAELVSDVWTLFD--ILFIRSENKS------LVVSLQQSFQQCLNQSFGTSLHASLLQ 1237

  Fly  1083 NTSNSPALLGVNATGSPSPIENG--------------------RKSCGSASLGDSDGA 1120
            ::|::    |...|....|::..                    :|||......|:..|
Zfish  1238 HSSST----GAGETSQTDPLKQKHRNTLKRMREFFTTKSTIAVKKSCNDKGKKDTTAA 1291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bon	NP_001262765.1	zf-RING_5	82..130	CDD:291308	18/55 (33%)
		BBOX	239..275	CDD:237988	19/35 (54%)
		BBC	284..409	CDD:128778	28/125 (22%)
		PHD_TIF1_like	899..943	CDD:277016	20/75 (27%)
		Bromo_tif1_like	963..1072	CDD:99934	24/108 (22%)
trim33l	XP_005158134.1	zf-RING_UBOX	25..65	CDD:290181	15/47 (32%)
		BBOX	90..132	CDD:197662	19/47 (40%)
		zf-B_box	143..182	CDD:279037	19/38 (50%)
		PHD_TIF1_like	1071..1113	CDD:277016	19/43 (44%)
		Bromodomain	1133..1228	CDD:295360	25/111 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003753
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910