DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bon and Pml

DIOPT Version :9

Sequence 1:	NP_001262765.1	Gene:	bon / 44235	FlyBaseID:	FBgn0023097	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	XP_038938327.1	Gene:	Pml / 315713	RGDID:	1562602	Length:	925	Species:	Rattus norvegicus

Alignment Length:	1215	Identity:	213/1215 - (17%)
Similarity:	338/1215 - (27%)	Gaps:	500/1215 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 DSAEKRSESNSSASAKFTLFKCVYCAQLLGSNDRPKLLECLHVACAQCVSTKFSELDRSLPPLIH 126
            |....:|.:..:...:|...:|..|..   ....||||.|||..|:.|:..          |.:.
  Rat    10 DHEHSQSPAEQAIKEEFQFLRCPGCQT---QAKCPKLLPCLHTLCSGCLEA----------PGLQ 61

  Fly   127 CPVCD---NASQQEFIVDNQFLIEQCTAGDSGDGVGLLGLTGEGQKSSAA-------ASIQCSSC 181
            ||:|.   :|:.....:||.|.                    |..:...|       |...|:.|
  Rat    62 CPICQAPGSANANAEALDNVFF--------------------ESLQRRLAVFRQIVDAQAACTRC 106

  Fly   182 SDGAVATSWCVDCSEYICDSCVQAHQ-RLKITKDHTIKPKDEA---------------------N 224
            .:  :|..||.:|.:.:|..|..||| .||    |..:|..|.                     .
  Rat   107 KE--LADFWCFECEQLMCGKCFDAHQWYLK----HEARPLAELRDNSVREFLDSTRKSNIFCSNT 165

  Fly   225 NEQLAGAAGV-------------------DKLHMCQL----HPQEKLSLFCETCDKLTCRDCQLS 266
            |.:......|                   .:...|.|    .|.:...::|..|.|..|.:|.|.
  Rat   166 NHRTPAQTNVIMQSPFILEEMTDPHSTIPPQRSACLLPTNSKPLQVYFIYCRGCAKPLCCECALL 230

  Fly   267 DHRDHKYKFAHEIATESRQALSTLVSEINYKRFLLSSATKVIDDRQQLIH-------DKKKDLIK 324
            | |:|.: ...||..|.:|    |..|:......|....:..|.....:|       |.:.|..|
  Rat   231 D-RNHSH-LQCEIGKEIQQ----LHEELGTMTQALEEQGRTFDSAHAQMHSAIGQLDDARSDTEK 289

  Fly   325 EITAMAVKITNTVNTRGKQLIMRLNEVCDSKLKVLVEKKETLQLLSDNTDHCIDFMQ-----NAL 384
            :|.|...::...|..:.::|:..:|          |..:...|.::....|....:|     .||
  Rat   290 QIRARVRQVIEHVQAQERELLEAVN----------VRYQRDYQEIAGQLGHLEAVLQRIRTGGAL 344

  Fly   385 EKGSDFAILSSKKSLVRH--LQKLKCQRADIPNPEIPVRIQVQLNQ---------VSDLQKVISQ 438
            .|.... ..|.::.|..|  |:|..|:.    ..|.|...:|||..         :.||...|:|
  Rat   345 VKRMKL-YASEQEVLDMHGFLRKALCRL----RQEEPQNHKVQLRTSGFEEFKLCLQDLVSFITQ 404

  Fly   439 LGIIIVDGKPYPPTPSPNGTPQPQHPPRQPPSPNMAPPLRPGLPPGMPAGLSPNGPPVNFGPQNG 503
            ...:.|.|:..|...|       .||......|..|
  Rat   405 RTDVAVAGRASPEAAS-------THPEAASAQPEAA----------------------------- 433

  Fly   504 PPLYSNAAQQQFNNLSMSRSFPGDGSGKVRFGGMPPVGMQRHGQPHVSSSTHPQNMDISLRGLLN 568
                                                             ||||:
  Rat   434 -------------------------------------------------STHPE----------- 438

  Fly   569 NQAAQSPNAHMAFNGPPSYPGGPQGAPAPAHQPMGPQMRPHFMPGQQGFSQGGGPGGGPRDANFM 633
             .|:..|.|..|.         |:.|..|                           |...|....
  Rat   439 -AASAQPEAASAH---------PESASTP---------------------------GNSTDLEQP 466

  Fly   634 NSNARFQSQYQRMANHAQQAAAAAAMAGAAGGGGGQIPSP---GALQRPQMMSNPMQNVSAMQNS 695
            ....|.|:|...::. .|..|...::.||.       |.|   .::|.|.......|.||.|:..
  Rat   467 KEVQRAQAQAMELSK-TQPVAMVKSVPGAH-------PVPVYAFSMQGPTYREEASQTVSPMKRK 523

  Fly   696 LGFHGSQAGFNTGPPQTSPQLGGGGMHSLAKWHIPQSAQQSNMCSQQGPLLPFANGRQTSEN-FK 759
            .                              .||.        |.::     ......|.|| .:
  Rat   524 C------------------------------CHID--------CCRK-----IIKMESTDENEDR 545

  Fly   760 ISLKS-----PNTLKNSTPPSLGGGGAGHQGHGNGSSSAQLNAAALGLGPAVSILSNVTSTNP-- 817
            :|..|     |:|.|..:||           |.:|:||.:                   ||.|
  Rat   546 LSTSSPEQPRPSTSKAISPP-----------HPDGTSSTE-------------------STIPEK 580

  Fly   818 KTPSPSTHENTKDFTEPIDKVRDDSINDLIATIAKLDSNGVQVLPEGRTKTTSPQVHSSTDLSNT 882
            :||.|:.:....|..|..::         |..|:..:.:..:.||......:|.: .||..|...
  Rat   581 ETPLPNNNHVASDAGETEER---------IVVISSSEDSDAENLPSHELDDSSSE-SSSIQLEGP 635

  Fly   883 QEVNNKNEQKDDPN-EDWCAVCLDGGELMCCDKCPKV---------------------------- 918
            ..:...:|...:|: ||...|..|   |...::..|:
  Rat   636 NSLKALDESLAEPHLEDRTLVFFD---LKIDNETQKISQLAAVNRESKFRVLIQPEAFSVYSKAV 697

  Fly   919 -----------FHQNCHIPAIS--------------SLPDESESWQC------LLCV-------- 944
                       |..:.|.|.::              :|.|.::.|:.      .|.|
  Rat   698 SLESGLQHFLSFLNSMHRPLLACPRLWGPGLPIFFQALNDINKLWEFQDAISGFLAVLPLIQERI 762

  Fly   945 ------NIKELTKT----EGSEKSSSGELSALE-----------LRILQRI----CLELYCQYE- 983
                  .::.|.||    ..||:|:...:.|:.           |::.|.|    .|:.:...:
  Rat   763 PSASSFKLRNLAKTYLARNMSERSALAAVLAMRDLCCLLEVSPGLQLAQHIYSFSSLQCFASLQP 827

  Fly   984 --QSLNFREPESPA----NTSYYEIVSSPMSLDVIRTRLDPSSPNHYKDIAGFVSDVRLIFSNTY 1042
              |:....:||:..    |.|:.|::::..|             |..:.:..:|.         |
  Rat   828 LIQAQVLPQPEARLLALHNVSFLELLTAYRS-------------NRQEGLKKYVH---------Y 870

  Fly  1043 LFYQEDTKTYSNAKYLENFFEEQLAKWLPQFEGTKPQGKRNTSNS 1087
            |..|  |...|.:..:..|.:...|....|.||..|.|...|:.|
  Rat   871 LSLQ--TTPSSASTQIAQFLQALSAYMDGQLEGHIPAGAEGTALS 913

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bon	NP_001262765.1	zf-RING_5	82..130	CDD:291308	14/47 (30%)
		BBOX	239..275	CDD:237988	12/39 (31%)
		BBC	284..409	CDD:128778	26/138 (19%)
		PHD_TIF1_like	899..943	CDD:277016	10/102 (10%)
		Bromo_tif1_like	963..1072	CDD:99934	21/130 (16%)
Pml	XP_038938327.1	RING_Ubox	29..66	CDD:418438	14/49 (29%)
		RING-HC finger (C3HC4-type)	31..65	CDD:319361	14/46 (30%)
		Bbox1_TRIM19_C-V	100..142	CDD:380862	15/47 (32%)
		Bbox_SF	210..247	CDD:412124	12/38 (32%)
		DUF3583	252..615	CDD:403373	96/600 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910