DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bon and Trim28

DIOPT Version :9

Sequence 1:	NP_001262765.1	Gene:	bon / 44235	FlyBaseID:	FBgn0023097	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	NP_035718.2	Gene:	Trim28 / 21849	MGIID:	109274	Length:	834	Species:	Mus musculus

Alignment Length:	1097	Identity:	255/1097 - (23%)
Similarity:	378/1097 - (34%)	Gaps:	381/1097 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 ASGAPTTSSLSSSSLSLSNPCDSAEKRSESNSSASAKFT--------------LFKCVYCAQLLG 91
            |:.|.|.:|.:|.|..........|||..::|:|:|...              |..|..|.:.|.
Mouse    10 AASAATAASAASGSPGSGEGSAGGEKRPAASSAAAASAAASSPAGGGGEAQELLEHCGVCRERLR 74

  Fly    92 SNDRPKLLECLHVACAQCVSTKFSELDRSLP---------------PLIHCPVCDNASQQEFIVD 141
            ....|:||.|||.||:.|       |..:.|               .::.||||......:.||:
Mouse    75 PERDPRLLPCLHSACSAC-------LGPATPAAANNSGDGGSAGDGAMVDCPVCKQQCYSKDIVE 132

  Fly   142 NQFLIEQCTAGDSGDGVGLLGLTGEGQKSSAAASIQCSSCSDGAVATSWCVDCSEYICDSCVQAH 206
            |.|:      .|||         .:....|..|:..|:||.|.|.|||:||:|||.:|::||:||
Mouse   133 NYFM------RDSG---------SKASSDSQDANQCCTSCEDNAPATSYCVECSEPLCETCVEAH 182

  Fly   207 QRLKITKDHTIKPKDEANNEQLAGAAGVDKLHMCQLHPQEKLSLFCETCDKLTCRDCQLSDHRDH 271
            ||:|.|||||::....|....      .::...|.:|..|.|.||||:||.||||||||:.|:||
Mouse   183 QRVKYTKDHTVRSTGPAKTRD------GERTVYCNVHKHEPLVLFCESCDTLTCRDCQLNAHKDH 241

  Fly   272 KYKFAHEIATESRQALSTLVSEINYKRFLLSSATKVIDDRQQLIHDKKKDLIKEITAMAVKITNT 336
            :|:|..:.....|:.|::||..:..|...|...||.:....:.:.|.:|.:..::....::|...
Mouse   242 QYQFLEDAVRNQRKLLASLVKRLGDKHATLQKNTKEVRSSIRQVSDVQKRVQVDVKMAILQIMKE 306

  Fly   337 VNTRGKQLIMRLNEVCDSKLKVLVEKKETLQLLSDNTDHCIDFMQNALEKGSDFAILSSKKSLVR 401
            :|.||:.|:....:|.:.:.:.|..:..|:..:..:.:|.:.|...|||..::.|:|.|||.:..
Mouse   307 LNKRGRVLVNDAQKVTEGQQERLERQHWTMTKIQKHQEHILRFASWALESDNNTALLLSKKLIYF 371

  Fly   402 HLQKLKCQRADIPNPEIPVRIQVQLNQVSDLQKVISQLGIIIVDGKPYPPTPSPNGT-PQPQHPP 465
            .|.:......|...|...::.|..||..:   |.....|.|:.:      .|..|.| |.|..||
Mouse   372 QLHRALKMIVDPVEPHGEMKFQWDLNAWT---KSAEAFGKIVAE------RPGTNSTGPGPMAPP 427

  Fly   466 RQPPSPNMAPPLRPGLPPGMPAGLSPNGPPVNFGPQNGPPLYSNAAQQQFNNLSMSRSFPGDGSG 530
            |.|     .|..:.|.....|..:..     .:|..:..| || :|:...:.:..|||..|:.||
Mouse   428 RAP-----GPLSKQGSGSSQPMEVQE-----GYGFGSDDP-YS-SAEPHVSGMKRSRSGEGEVSG 480

  Fly   531 KVRFGGMPPVGMQR-------HGQPHV-----SSSTHPQNMDISLRGLLNNQAAQSPNAHMAFNG 583
            .:|  .:|.|.::|       ..||.|     .|:|...|:.:..||      |.:..|..|...
Mouse   481 LLR--KVPRVSLERLDLDLTSDSQPPVFKVFPGSTTEDYNLIVIERG------AAAAAAGQAGTV 537

  Fly   584 PPSYPGGPQ----------------GAPAPAHQPMGPQMRPHFMPGQQGFSQGGGPGGGPRDANF 632
            ||..||.|.                |||..|  |.||:.:|..||..:|
Mouse   538 PPGAPGAPPLPGMAIVKEEETEAAIGAPPAA--PEGPETKPVLMPLTEG---------------- 584

  Fly   633 MNSNARFQSQYQRMANHAQQAAAAAAMAGAAGGGGGQIPSPGALQRPQMMSNPMQNVSAMQNSLG 697
                                                    |||
Mouse   585 ----------------------------------------PGA---------------------- 587

  Fly   698 FHGSQAGFNTGPPQTSPQLGGGGMHSLAKWHIPQSAQQSNMCSQQGPLLPFANGRQTSENFKISL 762
                     .||...||
Mouse   588 ---------EGPRLASP------------------------------------------------ 595

  Fly   763 KSPNTLKNSTPPSLGGGGAGHQGHGNGSSSAQLNAAALGLGPAVSILSNVTSTNPKTPSPSTHEN 827
                                     :||:|:.|...|          ..|||.....|.
Mouse   596 -------------------------SGSTSSGLEVVA----------PEVTSAPVSGPG------ 619

  Fly   828 TKDFTEPIDKVRDDSINDLIATIAKLDSNGVQVLPEGRTKTTSPQVHSSTDLSNTQEVNNKNEQK 892
                      :.|||     |||
Mouse   620 ----------ILDDS-----ATI------------------------------------------ 627

  Fly   893 DDPNEDWCAVCLDGGELMCCDKCPKVFHQNCHIPAISSLPDESESWQCLLCVNIKELTKTEGS-- 955
                   |.||...|:|:.|::|...||.:||:||:..:|  .|.|.|.||..:.:|.:.:||
Mouse   628 -------CRVCQKPGDLVMCNQCEFCFHLDCHLPALQDVP--GEEWSCSLCHVLPDLKEEDGSLS 683

  Fly   956 --EKSSSG---ELSALELRILQRICLELYCQYEQSLNFREPESPA------NTSYYEIVSSPMSL 1009
              ...|:|   :||....|..:|:.|.|:|        .||..|.      :|...|.....:.|
Mouse   684 LDGADSTGVVAKLSPANQRKCERVLLALFC--------HEPCRPLHQLATDSTFSMEQPGGTLDL 740

  Fly  1010 DVIRTRLDPSSPNHYKDIAGFVSDVRLIFSNTYLFYQEDTKTYSNAKYLENFFEEQL 1066
            .:||.||.......|.....|..||..:|.. :....||.....:...|:.|||.::
Mouse   741 TLIRARLQEKLSPPYSSPQEFAQDVGRMFKQ-FNKLTEDKADVQSIIGLQRFFETRM 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bon	NP_001262765.1	zf-RING_5	82..130	CDD:291308	16/62 (26%)
		BBOX	239..275	CDD:237988	22/35 (63%)
		BBC	284..409	CDD:128778	29/124 (23%)
		PHD_TIF1_like	899..943	CDD:277016	17/43 (40%)
		Bromo_tif1_like	963..1072	CDD:99934	28/110 (25%)
Trim28	NP_035718.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	13..56		11/42 (26%)
		zf-RING_5	65..123	CDD:291308	18/64 (28%)
		BBOX	149..185	CDD:197662	20/35 (57%)
		BBOX	208..246	CDD:237988	22/37 (59%)
		Leucine zipper alpha helical coiled-coil region	247..377		29/129 (22%)
		Interaction with MAGEC2. /evidence=ECO:0000250	248..377		29/128 (23%)
		BBC	253..379	CDD:128778	29/125 (23%)
		Involved in binding PPP1CA. /evidence=ECO:0000250	367..371		1/3 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	412..480		21/85 (25%)
		HP1 box	476..513		10/38 (26%)
		PxVxL motif	481..494		4/14 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	581..602		11/180 (6%)
		PHD_TIF1beta	627..669	CDD:277093	18/92 (20%)
		Bromodomain	696..802	CDD:295360	28/110 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	79	1.000	Domainoid score	I8651
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330513at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm43166
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR25462
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11693
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	7	7.010