Protein Alignment bon and TRIM28

DIOPT Version :9

• Sequence 1: NP_001262765.1
• Gene: bon / 44235
• FlyBaseID: FBgn0023097
• Length: 1207
• Species: Drosophila melanogaster
• Sequence 2: XP_024307077.1
• Gene: TRIM28 / 10155
• HGNCID: 16384
• Length: 872
• Species: Homo sapiens
• Alignment Length: 1090
• Identity: 257/1090 - (23%)
• Similarity: 392/1090 - (35%)
• Gaps: 354/1090 - (32%)

  Fly    42 SGAPTTSSLSSSSLSLSNPCDSAEKRSESNSSASAKFTLFKCVYCAQLLGSNDRPKLLECLHVAC 106
            |.||:.::.:|:|.:.|:|         :...|.|...|..|..|.:.|.....|:||.|||.||
Human    33 STAPSAAASASASAAASSP---------AGGGAEALELLEHCGVCRERLRPEREPRLLPCLHSAC 88

  Fly   107 AQCVSTKFSELDRSL--------PPLIHCPVCDNASQQEFIVDNQFLIEQCTAGDSGDGVGLLGL 163
            :.|:.........|.        ..::.||||......:.||:|.|:      .|||
Human    89 SACLGPAAPAAANSSGDGGAAGDGTVVDCPVCKQQCFSKDIVENYFM------RDSG-------- 139

  Fly   164 TGEGQKSSAAASIQ-----CSSCSDGAVATSWCVDCSEYICDSCVQAHQRLKITKDHTIKPKDEA 223
                  |.||...|     |:||.|.|.|||:||:|||.:|::||:||||:|.|||||::....|
Human   140 ------SKAATDAQDANQCCTSCEDNAPATSYCVECSEPLCETCVEAHQRVKYTKDHTVRSTGPA 198

  Fly   224 NNEQLAGAAGVDKLHMCQLHPQEKLSLFCETCDKLTCRDCQLSDHRDHKYKFAHEIATESRQALS 288
            .:..      .::...|.:|..|.|.||||:||.||||||||:.|:||:|:|..:.....|:.|:
Human   199 KSRD------GERTVYCNVHKHEPLVLFCESCDTLTCRDCQLNAHKDHQYQFLEDAVRNQRKLLA 257

  Fly   289 TLVSEINYKRFLLSSATKVIDDRQQLIHDKKKDLIKEITAMAVKITNTVNTRGKQLIMRLNEVCD 353
            :||..:..|...|..:||.:....:.:.|.:|.:..::....::|...:|.||:.|:....:|.:
Human   258 SLVKRLGDKHATLQKSTKEVRSSIRQVSDVQKRVQVDVKMAILQIMKELNKRGRVLVNDAQKVTE 322

  Fly   354 SKLKVLVEKKETLQLLSDNTDHCIDFMQNALEKGSDFAILSSKKSLVRHLQKLKCQRADIPNPEI 418
            .:.:.|..:..|:..:..:.:|.:.|...|||..::.|:|.|||.:...|.:......|...|..
Human   323 GQQERLERQHWTMTKIQKHQEHILRFASWALESDNNTALLLSKKLIYFQLHRALKMIVDPVEPHG 387

  Fly   419 PVRIQVQLNQVSDLQKVISQLGIIIVDGKPYPPTPSPNGT-PQPQHPPRQPPSPNMAPPLRPGLP 482
            .::.|..||..:   |.....|.|:.:      .|..|.| |.|..|||.|     .|..:.|..
Human   388 EMKFQWDLNAWT---KSAEAFGKIVAE------RPGTNSTGPAPMAPPRAP-----GPLSKQGSG 438

  Fly   483 PGMPAGLSPNGPPVNFGPQNGPPLYSNAAQQQFNNLSMSRSFPGDGSGKVRFGGMPPVGMQRHGQ 547
            ...|..:...   ..||..:.|  || :|:...:.:..|||..|:.||.:|  .:|.|.::|
Human   439 SSQPMEVQEG---YGFGSGDDP--YS-SAEPHVSGVKRSRSGEGEVSGLMR--KVPRVSLER--- 492

  Fly   548 PHVSSSTHPQNMDISLRGLLNNQAAQSPNAHMAFNGPPSYPGGPQGAPAPAHQPMGPQMRPHFMP 612
                       :|:.|      .|...|.....|
Human   493 -----------LDLDL------TADSQPPVFKVF------------------------------- 509

  Fly   613 GQQGFSQGGGPGGGPRDANFMNSNARFQSQYQRMANHAQQAAAAAAMAGAAGGGGGQIPSPGALQ 677
                      ||....|.|.:        ..:|.|     ||||....|.|..|     :|||
Human   510 ----------PGSTTEDYNLI--------VIERGA-----AAAATGQPGTAPAG-----TPGA-- 544

  Fly   678 RPQMMSNPMQNVSAMQNSLGFHGSQAGFNTGPPQTSPQLGGGGMHSLAKWHIPQSAQQSNMCSQQ 742
                                                |.|.|   .::.|....::|..:...:.:
Human   545 ------------------------------------PPLAG---MAIVKEEETEAAIGAPPTATE 570

  Fly   743 GPLLPFANGRQTSENFKISLKSPNTLKNSTPPSLGGGGAGHQGHGNGSSSAQLNAAALGLGPAVS 807
            ||                          .|.|.|                     .||..||.
Human   571 GP--------------------------ETKPVL---------------------MALAEGPG-- 586

  Fly   808 ILSNVTSTNPKTPSPSTHENTKDFTEPIDKVRDDSINDLIATIAKLDSNGVQVL-PEGRTKTTSP 871
                  :..|:..|||..                            .|:|::|: |||   |::|
Human   587 ------AEGPRLASPSGS----------------------------TSSGLEVVAPEG---TSAP 614

  Fly   872 QVHSSTDLSNTQEVNNKNEQKDDPNEDWCAVCLDGGELMCCDKCPKVFHQNCHIPAISSLPDESE 936
            .....| |.::..:              |.||...|:|:.|::|...||.:||:||:..:|  .|
Human   615 GGGPGT-LDDSATI--------------CRVCQKPGDLVMCNQCEFCFHLDCHLPALQDVP--GE 662

  Fly   937 SWQCLLCVNIKELTKTEGS----EKSSSG---ELSALELRILQRICLELYCQYEQSLNFREPESP 994
            .|.|.||..:.:|.:.:||    ...|:|   :||....|..:|:.|.|:|        .||..|
Human   663 EWSCSLCHVLPDLKEEDGSLSLDGADSTGVVAKLSPANQRKCERVLLALFC--------HEPCRP 719

  Fly   995 ----ANTSYYEIVSSPM---------------------------------------SLDVIRTRL 1016
                |..|.:.:||..|                                       .|.:||.||
Human   720 LHQLATDSTFSLVSPRMGKGKGVVAAGSRPQPVHVYVCLCVCMCDLCLQDQPGGTLDLTLIRARL 784

  Fly  1017 DPSSPNHYKDIAGFVSDVRLIFSNTYLFYQEDTKTYSNAKYLENFFEEQL 1066
            .......|.....|..||..:|.. :....||.....:...|:.|||.::
Human   785 QEKLSPPYSSPQEFAQDVGRMFKQ-FNKLTEDKADVQSIIGLQRFFETRM 833

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
bon	NP_001262765.1	zf-RING_5	82..130	CDD:291308	15/55 (27%)
		BBOX	239..275	CDD:237988	22/35 (63%)
		BBC	284..409	CDD:128778	29/124 (23%)
		PHD_TIF1_like	899..943	CDD:277016	17/43 (40%)
		Bromo_tif1_like	963..1072	CDD:99934	31/147 (21%)
TRIM28	XP_024307077.1	RING-HC_TIF1beta	62..124	CDD:319679	18/61 (30%)
		RING-HC finger (C3HC4-type)	65..120	CDD:319679	15/54 (28%)
		BBOX	148..184	CDD:197662	19/35 (54%)
		BBOX	207..245	CDD:237988	22/37 (59%)
		BBC	252..378	CDD:128778	29/125 (23%)
		BASP1	<525..620	CDD:330577	37/231 (16%)
		PHD_TIF1beta	627..669	CDD:277093	17/57 (30%)
		Bromodomain	696..839	CDD:321986	31/147 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	75	1.000	Domainoid score	I9077
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330513at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm41095
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR25462
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R11693
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	7	7.010