DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bon and trim28

DIOPT Version :9

Sequence 1:	NP_001262765.1	Gene:	bon / 44235	FlyBaseID:	FBgn0023097	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	XP_002937648.1	Gene:	trim28 / 100489687	XenbaseID:	XB-GENE-1005536	Length:	762	Species:	Xenopus tropicalis

Alignment Length:	1017	Identity:	222/1017 - (21%)
Similarity:	349/1017 - (34%)	Gaps:	364/1017 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    80 LFKCVYCAQLLGSNDRPKLLECLHVACAQC---------VSTKFSELDRSLPPLIHCPVCDNASQ 135
            |..|..|.:.|.::..|:||.|||..|..|         |:|...:|..:   :::||:|.:...
Frog    31 LESCGVCKKQLRADTEPQLLPCLHSVCRACLPPETPAPEVATNSGDLASA---VVNCPICKHQCF 92

  Fly   136 QEFIVDNQFLIEQCTAGDSGDGVGLLGLTGEGQKSSAAASIQ-CSSCSDGAVATSWCVDCSEYIC 199
            |:.||:|.||..:.|:                  .....:|| |:||.|..||.|:||:|:|::|
Frog    93 QKDIVENYFLKVEPTS------------------EPVTETIQRCTSCDDNTVANSYCVECTEWLC 139

  Fly   200 DSCVQAHQRLKITKDHTIKPKDEANNEQLAGAAGVDKLHMCQLHPQEKLSLFCETCDKLTCRDCQ 264
            ::||:||||:|.|||||||.|..:..|       .::...|.||..|.|.|:||:||.|||||||
Frog   140 ETCVEAHQRVKYTKDHTIKVKSSSKKE-------TERAVYCPLHKNEPLMLYCESCDTLTCRDCQ 197

  Fly   265 LSDHRDHKYKFAHEIATESRQALSTLVSEINYKRFLLSSATKVIDDRQQLIHDKKKDLIKEITAM 329
            |..|:||:|:|..:.....|:.||.||..:..|...|..:||.:....:.:.|.:|.|..::...
Frog   198 LQGHKDHQYQFLEDAVKNQRKVLSALVKRLGDKHTALQKSTKDVRTSIRQVSDLQKRLQVDVKMA 262

  Fly   330 AVKITNTVNTRGKQLIMRLNEVCDSKLKVLVEKKETLQLLSDNTDHCIDFMQNALEKGSDFAILS 394
            .:.|...:|.|||.|:..:.:|.:.....|.::...:..|..:.:|.:.|...|||..::.|:|.
Frog   263 ILHIMKELNKRGKLLVNDMQKVTEGHQDKLEKQHWAMNKLQKHQEHILRFATWALESDNNIALLL 327

  Fly   395 SKKSLVRHLQKLKCQRADIPNPEIPVRIQVQLNQVSDLQKVISQLGIIIVDGKPYPPTPSPNGTP 459
            |||.:  |.|                           |.:.:.    :|||
Frog   328 SKKLI--HFQ---------------------------LHRALK----VIVD-------------- 345

  Fly   460 QPQHPPRQPPSPNMAPPLRPGLPPGMPAGLSPNGPPVNFGPQNGPPLYSNAAQQQFNNLSMSRSF 524
                                               ||.       ||.....|...:..:....|
Frog   346 -----------------------------------PVE-------PLGDLKFQWDSDTWTKHAEF 368

  Fly   525 PGDGSGKVRFGGMPPVGMQRHGQPHVSSSTHPQNMDISLRGLLNNQAAQSPNAHMAFNGPPSYPG 589
                     ||   .:...:.|.|..||               .:.||||.|:..:
Frog   369 ---------FG---KIVCDKTGVPQSSS---------------GSLAAQSINSASS--------- 397

  Fly   590 GPQGAPAPAHQPMGPQMRPHFMPGQQGFSQGGGPGGGPRDANFMNSNARFQSQYQRMANHAQQAA 654

Frog   398 ----------------------------------------------------------------- 397

  Fly   655 AAAAMAGAAGGGGGQIPSPGALQRPQMMSNPMQNVSAMQNSLGFHGSQA-----GFNTGPPQTSP 714
                                     |||.:             |.||.|     ||:|.|.|...
Frog   398 -------------------------QMMDD-------------FDGSSAEGESSGFDTFPGQKRG 424

  Fly   715 QLGGGGMHSLAKWHIPQSAQQSNMCSQQGPLLPFANGRQTSENFKISLKSPNTLKNSTPPSLGGG 779
            :...|.::.|.| .:|                     |.:.|...:.| :|:|    .||..
Frog   425 RSSEGDVNELLK-KVP---------------------RVSLERLDVDL-NPDT----QPPVF--- 459

  Fly   780 GAGHQGHGNGSSSAQLNAAALGLGPAVSILSNVTSTNPKTPSPSTHENTKDFTEPIDKVRDDSIN 844
               ....||.:....|.....|..|..:::.. .:.....|.|::..:.|...
Frog   460 ---KVFPGNTNEDYNLIVIERGNLPGEAVVKE-EAMETGIPIPTSDRSEKSLV------------ 508

  Fly   845 DLIATIAKLDSNGVQVLPEGRTKTTSPQVHSSTDLSNTQEVNNKNEQ----KDDPNEDWCAVCLD 905
                           :.|:|.|:|..|.:...|...|....:.:...    .|..:...|.||..
Frog   509 ---------------IRPDGSTETVPPVIRQPTAAGNATSSDFQGASSGGFSDGLSGARCKVCQK 558

  Fly   906 GGELMCCDKCPKVFHQNCHIPAISSLPDESESWQCLLCVNIKELTKTE------GSEKSSSGELS 964
            .|.|:.|.:|..:||::||:|::..:  .|.:|:|:||.::  :.|.:      .|....|..||
Frog   559 EGALLTCSQCRSLFHRDCHLPSVMEM--TSGAWKCMLCQDL--VPKNDQGVDMIQSPAVDSSRLS 619

  Fly   965 ALELRILQRICLELYCQYEQSLNFREPESPANTSYYEIVSS----PM-SLDVIRTRLDPSSPNHY 1024
            ..:.:..:|:.||:.|        .||..|    ::.:.||    || .|..||.||.......|
Frog   620 PSDQKKCERLLLEMLC--------HEPCRP----FHRLSSSSENDPMIDLTFIRARLQQKRSPSY 672

  Fly  1025 KDIAGFVSDVRLIFSNTYLFYQEDTKTYSNAKYLENFFEEQL 1066
            .....||.||.::|.:.... .||.....:...|::|||.:|
Frog   673 STPEDFVRDVWMMFRSVSKL-AEDKAVVQSIIELQSFFETRL 713

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bon	NP_001262765.1	zf-RING_5	82..130	CDD:291308	16/56 (29%)
		BBOX	239..275	CDD:237988	22/35 (63%)
		BBC	284..409	CDD:128778	33/124 (27%)
		PHD_TIF1_like	899..943	CDD:277016	15/43 (35%)
		Bromo_tif1_like	963..1072	CDD:99934	31/109 (28%)
trim28	XP_002937648.1	zf-RING_5	34..89	CDD:291308	17/57 (30%)
		BBOX	116..149	CDD:197662	18/32 (56%)
		BBOX	171..209	CDD:237988	22/37 (59%)
		iSH2_PI3K_IA_R	216..341	CDD:304922	34/153 (22%)
		PHD_TIF1beta	552..594	CDD:277093	15/43 (35%)
		Bromodomain	618..719	CDD:295360	31/109 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	70	1.000	Domainoid score	I9410
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330513at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm48303
Panther	1	1.100	-	-	O	PTHR25462
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.020