DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment bon and trim66

DIOPT Version :9

Sequence 1:	NP_001262765.1	Gene:	bon / 44235	FlyBaseID:	FBgn0023097	Length:	1207	Species:	Drosophila melanogaster
Sequence 2:	XP_004913384.2	Gene:	trim66 / 100485708	XenbaseID:	XB-GENE-997108	Length:	1218	Species:	Xenopus tropicalis

Alignment Length:	1260	Identity:	288/1260 - (22%)
Similarity:	445/1260 - (35%)	Gaps:	411/1260 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 CSSCSDGAVATSWCVDCSEYICDSCVQAHQRLKITKDHTIK--PKDEANNEQLAGAAGVDKLHMC 240
            |..|::...|.|.|:.|::::|.:|.:.|:..|...|..|.  .:..|.|:..:|     ....|
Frog     5 CFDCTEKNSAHSLCITCNKWLCSTCAEQHRHTKSVSDPFIPAVQRGSAGNDGTSG-----NFLCC 64

  Fly   241 QLHPQEKLSLFCETCDKLTCRDCQLSDHRDHKYKFAHEIATESRQALSTLVSEINYKRFLLSSAT 305
            .||.||.|.|||||||.|.||.|.:.:|:||:::...|.....|..|..:::::..|:.::.:|.
Frog    65 PLHHQESLKLFCETCDTLVCRHCVVMEHKDHRFRRLDEALQHQRAVLENVITQVEEKKVVVQAAG 129

  Fly   306 KVIDDRQQLI---HDKKKDLIKEITAMAVKITNTVNTRGKQLIMRLNEVCDSKLKVLVEKKETLQ 367
            |.|:||...|   |.|.::.|| :|.|.  :.|.:|.|...|:.:|.::...|.....::.:::.
Frog   130 KQIEDRLYEIKHMHSKVENQIK-VTKMV--LINELNKRTNVLLEQLEKITTEKRHKYEQQLQSIL 191

  Fly   368 LLSDNTDHCIDFMQNALEKGSDFAILSSKKSLVRHLQKL---KCQRADIPNPEIPVRIQVQLN-Q 428
            :|:...:|..:|:..|:...:....|.||:.:|..:|:|   .|      ..::....:::.: :
Frog   192 VLNRQLEHVQNFINWAMYGKNSIPFLFSKELIVYQMQRLLDTSC------GGDVGRTSKIRFSWE 250

  Fly   429 VSDLQKVISQLGIIIVDG-----------------KPYPPTP-------------SPN------- 456
            .|...|.||.||.::.||                 .||.|.|             ||:
Frog   251 PSFWTKQISNLGCLMADGAHLPTPDIPTYGTENAQAPYYPAPHVPITAHPGTITSSPHYTSSVQC 315

  Fly   457 ----------------------GTPQPQ----HP----PRQPPS----------PNMAP------ 475
                                  ||..|.    ||    .:||||          |.:.|
Frog   316 PTPMCCTHCHTLPTVPKNQPATGTVTPHVSFAHPTPIKQQQPPSTQYNSSKEQKPTVRPLRVIQP 380

  Fly   476 --------------------PLRPGLPPGMPAGLSPNGPPVNFGPQNGPPLYSNAAQQQFNNL-- 518
                                ..:|.:||.     .||.|||  .|.  ||       |.||.:
Frog   381 WVSHQPQAEQENSPYWLDHQQQKPQVPPS-----QPNAPPV--CPV--PP-------QDFNQVHN 429

  Fly   519 --SMSRSFPGDGSGKVRFGGM---------PPVGMQ-------RHGQPH---------VSSSTHP 556
              ::..:.|......::...:         |.|.||       .|.||.         .:.|.|.
Frog   430 VHTIQHTVPITTPTSLQAPSVLQTPSVLQAPSVQMQVSSVHSLSHIQPQRLQQQSALCQAESAHE 494

  Fly   557 QNMDISLRGLLNNQ------------AAQSPNAHMAFNGPPSYPGGPQG---------APAPAHQ 600
            |.|..|| .::|.|            ..||..:::..| |...|...|.         ...||..
Frog   495 QVMHHSL-DIINQQFELEQMQKGLELLLQSQPSNVQLN-PTKQPQHVQQTIVGQINYIVRQPATA 557

  Fly   601 PMGPQMRPHFMPGQQGFSQGGGPGGGPRDANFMNSNARFQSQYQRMANHAQQAAAAAAMAGAAGG 665
            |:.|   |..:|  |...:...||....|.:.:.:::....|.|.:|:....|.
Frog   558 PLQP---PEEIP--QVCDEPISPGSHTVDLSPVTTSSPSNMQSQSIADEIIAAV----------- 606

  Fly   666 GGGQIPSPGALQRPQMMSNPMQNVSAMQNSLGFHG----------------------SQAGFNTG 708
                  ...|.||.|:.:||.:..||   |:||..                      |...|.
Frog   607 ------ENDACQRNQLAANPERKRSA---SVGFCNVPEMELSSPRLSRSVDPQMPTVSCQFFE-- 660

  Fly   709 PPQTSPQLGGGGMHSLAKWHIPQSAQQSN-------------------MCSQQGPLLPFANGR-- 752
            ||:....|.|.....||::...::|...|                   :|..:......||..
Frog   661 PPEDRGFLPGTEAERLAEYTAVEAAVADNIHVATEDHQATGAAVLGNAICKVENEDFSCANSAAI 725

  Fly   753 ----QT-------------------SENFKISLKS---PNT----LKNST--PPSLG-------- 777
                ||                   .|...:|:|.   |.|    :|..|  ||:.|
Frog   726 DTDLQTESAPPVISSEFILPLPEAFEEPINLSVKKCPPPETSSVIVKKPTHLPPAPGKPLKHETE 790

  Fly   778 ------GGGAGHQGHGNGSSS--------------AQLNAAALGLGPAVSI-------------- 808
                  ....|.:|..|...:              .::.|...|..|...:
Frog   791 DRGFKPSFAEGRKGKENTPRTPARETRIPYVRLERLKIQAPNSGELPVFKVQPQKKDEDGSVRLV 855

  Fly   809 -------LSNVTSTNPKTPSPSTHENTKDF----TEPIDKVRDDSINDL---IATIAKLDSNGVQ 859
                   .|.....||..|..|.|...:..    ||||......:|::|   :..:|::.....:
Frog   856 VKYGAQSKSMSIKVNPDCPYSSPHPAPQPAMPYGTEPIPYTTSQTISELEQQVNNLARVSPYSGE 920

  Fly   860 VLPEGRTKTTSPQVHSSTDLSNTQEVN------NKNEQKDD----PNEDWCAVCLDGGELMCCDK 914
             .|..|.:..:|.. ...|...|.:||      .|..|.:|    .|||:|||||:|||::|||:
Frog   921 -SPAFRNRIEAPAA-PIEDPEVTCKVNAAPQPTRKPVQSEDHDQLENEDFCAVCLNGGEMLCCDR 983

  Fly   915 CPKVFHQNCHIPAISSLPDESESWQCLLCVNIKELTKTE--------------GSEKSSSGELSA 965
            ||||||.:||:||:.|.|  ...|.|.||.|   |||.|              ..|.::...|..
Frog   984 CPKVFHLSCHVPALLSFP--VGEWLCTLCRN---LTKPEVEYDCDNVRYCLENKMEIAAFPNLDD 1043

  Fly   966 LELRILQRICLELYCQYEQSLNFREPESPANTSYYEIVSSPMSLDVIRTRLDPSSPNHYKDIAGF 1030
            .:.|..:.:.|.|.|. ..||.|:||.||....||:|:..||.|.:||.:|...:..||......
Frog  1044 YDQRKCETLVLSLCCN-SLSLPFQEPVSPLARHYYQIIKRPMDLSIIRKKLQRRNIPHYSAPEEL 1107

  Fly  1031 VSDVRLIFSNTYLF-----------YQEDTKTYSNAKYLENFFEEQLAKWLPQFEGTKPQGKRNT 1084
            |.|:||:|.|...|           ::||::.....:.||.:||..|.:..|:.....||.:.:.
Frog  1108 VYDIRLMFWNCAKFNYIGPAEQKAIFKEDSEVAEAGRNLEMYFENMLKEAYPEKVFPFPQEEDSD 1172

  Fly  1085 SNSPALLGVNATGSPSPIENGRKSC 1109
            :.                |.|.:||
Frog  1173 TE----------------EIGSESC 1181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
bon	NP_001262765.1	zf-RING_5	82..130	CDD:291308
		BBOX	239..275	CDD:237988	20/35 (57%)
		BBC	284..409	CDD:128778	31/130 (24%)
		PHD_TIF1_like	899..943	CDD:277016	25/43 (58%)
		Bromo_tif1_like	963..1072	CDD:99934	37/119 (31%)
trim66	XP_004913384.2	Bbox1_TRIM66	4..40	CDD:380869	10/34 (29%)
		Bbox2_TRIM66-like	62..104	CDD:380852	21/41 (51%)
		BBC	107..232	CDD:128778	31/127 (24%)
		PHA03247	<264..480	CDD:223021	41/231 (18%)
		PHA03247	<723..955	CDD:223021	39/233 (17%)
		PHD_TIF1delta	965..1013	CDD:277095	31/52 (60%)
		Bromo_tif1_like	1041..1160	CDD:99934	37/119 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D330513at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010