DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fray and OXSR1

DIOPT Version :9

Sequence 1:	NP_001303449.2	Gene:	fray / 44233	FlyBaseID:	FBgn0023083	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	XP_011532633.1	Gene:	OXSR1 / 9943	HGNCID:	8508	Length:	580	Species:	Homo sapiens

Alignment Length:	515	Identity:	289/515 - (56%)
Similarity:	374/515 - (72%)	Gaps:	19/515 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   200 GVGATAVVHGAYCIPRNEKCAIKRINLEKWNTSMDELLKEIQAMSSCFHENVVTYHTSFVVREEL 264
            |.||||||..|||.|:.||.|||||||||..||||||||||||||.|.|.|:|:|:|||||::||
Human    77 GSGATAVVQAAYCAPKKEKVAIKRINLEKCQTSMDELLKEIQAMSQCHHPNIVSYYTSFVVKDEL 141

  Fly   265 WLVLRLLEGGSLLDIIKHKMRTSNCKQGVFDEATIATVLKEVLKGLEYFHSNGQIHRDIKAGNIL 329
            |||::||.|||:||||||.:.....|.||.||:||||:|:|||:||||.|.|||||||:||||||
Human   142 WLVMKLLSGGSVLDIIKHIVAKGEHKSGVLDESTIATILREVLEGLEYLHKNGQIHRDVKAGNIL 206

  Fly   330 IGDDGTIQIADFGVSAWLATGRDLSRQKVRHTFVGTPCWMAPEVMEQDHGYDFKADIWSFGITAI 394
            :|:||::|||||||||:||||.|::|.|||.||||||||||||||||..||||||||||||||||
Human   207 LGEDGSVQIADFGVSAFLATGGDITRNKVRKTFVGTPCWMAPEVMEQVRGYDFKADIWSFGITAI 271

  Fly   395 EMATGTAPYHKYPPMKVLMLTLQNDPPTLDTGADDKDQYKAYGKTFRKMIVECLQKEPSKRPTAS 459
            |:|||.|||||||||||||||||||||:|:||..||:..|.|||:|||||..||||:|.|||||:
Human   272 ELATGAAPYHKYPPMKVLMLTLQNDPPSLETGVQDKEMLKKYGKSFRKMISLCLQKDPEKRPTAA 336

  Fly   460 ELLKHAFFKKAKDRKYLTQTLLQSGPSMETRVHKAAKRQPGASGRLHRTVTGEWVWSS---EEED 521
            |||:|.||:|||::::|.:..||..|::..|. |..:|.||:|||||:|..|.|.||.   :||.
Human   337 ELLRHKFFQKAKNKEFLQEKTLQRAPTISERA-KKVRRVPGSSGRLHKTEDGGWEWSDDEFDEES 400

  Fly   522 NGGSATGSGTGDRKHPSSDSDSE-----DRPMNRLERADSSDSDREEPSPEITHSVSSATVTPGA 581
            ..|.|..|.....:...|.|:||     |.....|:..:...:...:|:.:|....:..::   .
Human   401 EEGKAAISQLRSPRVKESISNSELFPTTDPVGTLLQVPEQISAHLPQPAGQIATQPTQVSL---P 462

  Fly   582 PAAAGAGAAQELTAGIAQLPLPSEAAGEAPPVNLVLRMRNLRRELHDIRFEFVVGKDTAEGIATE 646
            |.|..|..||.|::|       |.:.....|::||||:||.::||:||||||..|:|||||::.|
Human   463 PTAEPAKTAQALSSG-------SGSQETKIPISLVLRLRNSKKELNDIRFEFTPGRDTAEGVSQE 520

  Fly   647 LVDAGLVDALDTQPMATHLDQLIAASATMKTITFQLSSGVQPGEVPDERSLVGYAQISIT 706
            |:.|||||..|...:|.:|.:::....:.:::||:|:|||:..::||:..|:|:||:||:
Human   521 LISAGLVDGRDLVIVAANLQKIVEEPQSNRSVTFKLASGVEGSDIPDDGKLIGFAQLSIS 580

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fray	NP_001303449.2	STKc_OSR1_SPAK	191..467	CDD:270787	199/266 (75%)
fray	NP_001303449.2	OSR1_C	613..670	CDD:403428	30/56 (54%)
OXSR1	XP_011532633.1	STKc_OSR1_SPAK	77..344	CDD:270787	199/266 (75%)
OXSR1	XP_011532633.1	S_TKc	77..344	CDD:214567	199/266 (75%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	434	1.000	Domainoid score	I582
eggNOG	1	0.900	-	-		E1_KOG0582
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H31288
Inparanoid	1	1.050	585	1.000	Inparanoid score	I1007
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48016
OrthoDB	1	1.010	-	-		D280883at33208
OrthoFinder	1	1.000	-	-		FOG0002335
OrthoInspector	1	1.000	-	-		otm41227
orthoMCL	1	0.900	-	-		OOG6_101073
Panther	1	1.100	-	-	LDO	PTHR48012
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3029
SonicParanoid	1	1.000	-	-		X1048
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870