DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fray and STRADB

DIOPT Version :9

Sequence 1:	NP_001303449.2	Gene:	fray / 44233	FlyBaseID:	FBgn0023083	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_061041.2	Gene:	STRADB / 55437	HGNCID:	13205	Length:	418	Species:	Homo sapiens

Alignment Length:	404	Identity:	119/404 - (29%)
Similarity:	172/404 - (42%)	Gaps:	101/404 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   122 PRSQSQPAINNRRRPGTPPPHTVAPGNGTAS-SRSMTSIPANLSSNNVAGAATLPGAAAPPEKYT 185
            |..||:.:|           |.......|.| ||..|.....|.|.||:
Human    19 PEKQSETSI-----------HQYLVDEPTLSWSRPSTRASEVLCSTNVS---------------- 56

  Fly   186 WPNSKDDYELRDVIGVGATAV--VHGAYCIPRNEKCAIKRINLEKWNTSMDELLKEIQ---AMSS 245
                  .|||:..||.|...:  ||.|...|......||..|||..|   :|.||.:|   .:|.
Human    57 ------HYELQVEIGRGFDNLTSVHLARHTPTGTLVTIKITNLENCN---EERLKALQKAVILSH 112

  Fly   246 CF-HENVVTYHTSFVVREELWLVLRLLEGGSLLDIIKHKMRTSNCKQGVFDEATIATVLKEVL-- 307
            .| |.|:.||.|.|.|...||::...:..||...:    :||      .|.|....|:::.:|
Human   113 FFRHPNITTYWTVFTVGSWLWVISPFMAYGSASQL----LRT------YFPEGMSETLIRNILFG 167

  Fly   308 --KGLEYFHSNGQIHRDIKAGNILIGDDGTIQIADFGVSAWLATGRDLSRQKVRHTF----VGTP 366
              :||.|.|.||.|||.|||.:|||..||.:.::  |:|...:..:...|.:..:.|    ....
Human   168 AVRGLNYLHQNGCIHRSIKASHILISGDGLVTLS--GLSHLHSLVKHGQRHRAVYDFPQFSTSVQ 230

  Fly   367 CWMAPEVMEQD-HGYDFKADIWSFGITAIEMATGTAPYH------------KYPPMKVLMLT--- 415
            .|::||::.|| |||:.|:||:|.||||.|:|:|..|:.            |.||...|.::
Human   231 PWLSPELLRQDLHGYNVKSDIYSVGITACELASGQVPFQDMHRTQMLLQKLKGPPYSPLDISIFP 295

  Fly   416 -----LQNDPPTLDTGADDK-----------------DQYKAYGKTFRKMIVECLQKEPSKRPTA 458
                 ::|....:|:|..:.                 ...|.:...|..::..|||::|.|||:|
Human   296 QSESRMKNSQSGVDSGIGESVLVSSGTHTVNSDRLHTPSSKTFSPAFFSLVQLCLQQDPEKRPSA 360

  Fly   459 SELLKHAFFKKAKD 472
            |.||.|.|||:.|:
Human   361 SSLLSHVFFKQMKE 374

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fray	NP_001303449.2	STKc_OSR1_SPAK	191..467	CDD:270787	101/327 (31%)
fray	NP_001303449.2	OSR1_C	613..670	CDD:403428
STRADB	NP_061041.2	PK_STRAD_beta	59..386	CDD:270864	104/331 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0582
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810