Protein Alignment fray and Stk39

DIOPT Version :10

• Sequence 1: NP_001303449.2
• Gene: fray / 44233
• FlyBaseID: FBgn0023083
• Length: 707
• Species: Drosophila melanogaster
• Sequence 2: NP_062235.1
• Gene: Stk39 / 54348
• RGDID: 621643
• Length: 553
• Species: Rattus norvegicus
• Alignment Length: 587
• Identity: 316/587 - (53%)
• Similarity: 396/587 - (67%)
• Gaps: 53/587 - (9%)

  Fly   136 PGTPPPHTVAPGN------GTASSRSMTSIPANLSSNNVAGAATLPGAAAPP------EKYTWPN 188
            |...|.|...|..      ..|:..:.||.||...: ..|.||..|..||.|      :...||.
  Rat     4 PSGSPVHVQLPQQAAPVTAAAAAPAAATSAPAPAPA-PAAPAAPAPAPAAAPAPAPAAQAVGWPI 67

  Fly   189 SKDDYELRDVIGVGATAVVHGAYCIPRNEKCAIKRINLEKWNTSMDELLKEIQAMSSCFHENVVT 253
            .:|.|||::|||.||||||..|.|.||.|:.|||||||||..||||||||||||||.|.|.||||
  Rat    68 CRDAYELQEVIGSGATAVVQAALCKPRQERVAIKRINLEKCQTSMDELLKEIQAMSQCSHPNVVT 132

  Fly   254 YHTSFVVREELWLVLRLLEGGSLLDIIKHKMRTSNCKQGVFDEATIATVLKEVLKGLEYFHSNGQ 318
            |:|||||::|||||::||.|||:|||||:.:.....|.||.:||.|||:|||||:||:|.|.|||
  Rat   133 YYTSFVVKDELWLVMKLLSGGSMLDIIKYIVNRGEHKNGVLEEAIIATILKEVLEGLDYLHRNGQ 197

  Fly   319 IHRDIKAGNILIGDDGTIQIADFGVSAWLATGRDLSRQKVRHTFVGTPCWMAPEVMEQDHGYDFK 383
            ||||:||||||:|:||::|||||||||:||||.|::|.|||.||||||||||||||||..|||||
  Rat   198 IHRDLKAGNILLGEDGSVQIADFGVSAFLATGGDVTRNKVRKTFVGTPCWMAPEVMEQVRGYDFK 262

  Fly   384 ADIWSFGITAIEMATGTAPYHKYPPMKVLMLTLQNDPPTLDTGADDKDQYKAYGKTFRKMIVECL 448
            ||:|||||||||:|||.|||||||||||||||||||||||:||.:||:..|.|||:|||::..||
  Rat   263 ADMWSFGITAIELATGAAPYHKYPPMKVLMLTLQNDPPTLETGVEDKEMMKKYGKSFRKLLSLCL 327

  Fly   449 QKEPSKRPTASELLKHAFFKKAKDRKYLTQTLLQSGPSMETRVHKAAKRQPGASGRLHRTVTGEW 513
            ||:|||||||:||||..||:|||:|:||.:.||...|.:..|. |..:|.||:||.||:|..|:|
  Rat   328 QKDPSKRPTAAELLKCKFFQKAKNREYLIEKLLTRTPDIAQRA-KKVRRVPGSSGHLHKTEDGDW 391

  Fly   514 VWSSEEEDNGGSATGSGTGDRKHPSSDSDSEDRPMNRLERADSSDSDR--EEPSPEITHSVSSAT 576
            .||.:|                   .|..||:.     :.|.|.:..|  :|.:|||  ||::.
  Rat   392 EWSDDE-------------------MDEKSEEG-----KAAASQEKSRRVKEENPEI--SVNAG- 429

  Fly   577 VTPGAPAAAGAGAAQELTAGIAQ-LPLPSEAAGEAP-PVNLVLRMRNLRRELHDIRFEFVVGKDT 639
               |.|.     ..|.|:...:| .|..:|...|.| .||||||:||.|:||:||||||..|:||
  Rat   430 ---GIPE-----QIQSLSVHDSQGQPNANEDYREGPCAVNLVLRLRNSRKELNDIRFEFTPGRDT 486

  Fly   640 AEGIATELVDAGLVDALDTQPMATHLDQLIAASATMKTITFQLSSGVQPGEVPDERSLVGYAQIS 704
            |:|::.||..|||||..|...:|.:|.:::.....:||:||:|:||....|:|||..|:|:||:|
  Rat   487 ADGVSQELFSAGLVDGHDVVIVAANLQKIVDDPKALKTLTFKLASGCDGAEIPDEVKLIGFAQLS 551

  Fly   705 IT 706
            ::
  Rat   552 VS 553

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fray	NP_001303449.2	STKc_OSR1_SPAK	191..467	CDD:270787	203/275 (74%)
		OSR1_C	613..670	CDD:463491	32/56 (57%)
Stk39	NP_062235.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..55		15/51 (29%)
		STKc_OSR1_SPAK	70..346	CDD:270787	203/275 (74%)
		Interaction with RELT. /evidence=ECO:0000250|UniProtKB:Q9Z1W9	319..544		108/260 (42%)
		Nuclear localization signal. /evidence=ECO:0000255	369..375		2/6 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	370..431		26/91 (29%)
		Caspase cleavage related site	396..400		1/22 (5%)
		OSR1_C	460..517	CDD:463491	32/56 (57%)