DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fray and GckIII

DIOPT Version :9

Sequence 1:	NP_001303449.2	Gene:	fray / 44233	FlyBaseID:	FBgn0023083	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_650596.1	Gene:	GckIII / 42064	FlyBaseID:	FBgn0266465	Length:	642	Species:	Drosophila melanogaster

Alignment Length:	547	Identity:	173/547 - (31%)
Similarity:	249/547 - (45%)	Gaps:	101/547 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   185 TWPNSKDDYEL----RDVIGVGATAVVHGAYCIPRNEKCAIKRINLEKWNTSMDELLKEIQAMSS 245
            :| ..|.|.||    ::.||.|:...|.........:..|||.|:||:....:|::.:||..:|.
  Fly     2 SW-TEKVDPELIFTKQERIGKGSFGEVFKGIDNRTQQVVAIKIIDLEEAEDEIDDIQQEIMVLSQ 65

  Fly   246 CFHENVVTYHTSFVVREELWLVLRLLEGGSLLDIIKHKMRTSNCKQGVFDEATIATVLKEVLKGL 310
            |....|..|:.||:...:||:::..|.|||.||::         |.|.|:|..|..:|:||||||
  Fly    66 CDSPYVTKYYGSFLKGTKLWIIMEYLGGGSALDLM---------KAGSFEEMHIGIILREVLKGL 121

  Fly   311 EYFHSNGQIHRDIKAGNILIGDDGTIQIADFGVSAWLATGRDLSRQKVRHTFVGTPCWMAPEVME 375
            :|.||..::||||||.|:|:.:.|.:::|||||:     |:..:....|:||||||.||||||::
  Fly   122 DYLHSERKLHRDIKAANVLLSEQGDVKLADFGVA-----GQLTNTTSKRNTFVGTPFWMAPEVIK 181

  Fly   376 QDHGYDFKADIWSFGITAIEMATGTAPYHKYPPMKVLMLTLQNDPPTLDTGADDKDQYKAYGKTF 440
            |.. ||.||||||.||||||:|.|..|..:..||:||.|..:|:||.| ||        :|.|:|
  Fly   182 QSQ-YDAKADIWSLGITAIELAKGEPPNSELHPMRVLFLIPKNNPPQL-TG--------SYTKSF 236

  Fly   441 RKMIVECLQKEPSKRPTASELLKHAFFKKAKDRKYLTQTLLQSGPSMETRVHKAAKRQPGASGRL 505
            :..:..||.|:|..||||.||||:.|.||||...||...:        .|..|
  Fly   237 KDFVEACLNKDPENRPTAKELLKYPFIKKAKKNAYLIDLI--------DRFKK------------ 281

  Fly   506 HRTVTGEWVWSSEEEDNGGSATGSGTGDRKHPSSDSDSEDRP---------MNRLERADSSDSDR 561
                   |..|..:|....|.......|.|...|   |:|.|         :|...||..:....
  Fly   282 -------WKVSKGDESETESENSDSDSDAKQGGS---SQDEPWIMTVKGLHINSAPRAGVNSFQL 336

  Fly   562 EEPS------PEITHSVSSATVTPGAPA-----------AAGAGAAQELTA--GIAQLPLPSEAA 607
            :|..      .:.|||.:.......:||           ||.|.:...:||  |::       :|
  Fly   337 QEHELTMQKLMQTTHSPAGGGGVQASPAANALSSSVSAVAASASSVSVITANEGVS-------SA 394

  Fly   608 GEAPPVNLVLRMRNLRRELHDIRFEFVVGKDTAEGIATELVDAGLVDALDTQPMATHLDQLIAAS 672
            ...||.|..:...|    .::|....:..........|.|..|....::.:...|:.|.|..::|
  Fly   395 SALPPQNSHVHNHN----HNNINNNNIRNLSNKHATTTMLNAAPPPSSVTSSSSASELQQKRSSS 455

  Fly   673 ATMKTITFQLSSGVQPGEVPDERSLVG 699
               |....|..|.....:|.|.|:.:|
  Fly   456 ---KPELRQSRSAAPLDQVEDRRASLG 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fray	NP_001303449.2	STKc_OSR1_SPAK	191..467	CDD:270787	117/279 (42%)
fray	NP_001303449.2	OSR1_C	613..670	CDD:403428	9/56 (16%)
GckIII	NP_650596.1	STKc_MST3_like	12..283	CDD:270786	123/321 (38%)
GckIII	NP_650596.1	S_TKc	13..263	CDD:214567	114/273 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438548
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR48012
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940