DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fray and hpo

DIOPT Version :9

Sequence 1:	NP_001303449.2	Gene:	fray / 44233	FlyBaseID:	FBgn0023083	Length:	707	Species:	Drosophila melanogaster
Sequence 2:	NP_001261092.1	Gene:	hpo / 37247	FlyBaseID:	FBgn0261456	Length:	669	Species:	Drosophila melanogaster

Alignment Length:	481	Identity:	147/481 - (30%)
Similarity:	224/481 - (46%)	Gaps:	86/481 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   152 SSRSMTSIPANLSSNNVAGAATL--------PGAAAPPEKYTWPNSKDDYELRDVIGVGATAVVH 208
            |...:||: .::.|.|::.:.:.        .....||||.        :::...:|.|:...|:
  Fly     2 SEPEVTSV-VDMKSPNISSSCSFFKLKKLSEESLLQPPEKV--------FDIMYKLGEGSYGSVY 57

  Fly   209 GAYCIPRNEKCAIKRINLEKWNTSMDELLKEIQAMSSCFHENVVTYHTSFVVREELWLVLRLLEG 273
            .|.   ..|..:|..|.|....:.:.|::|||..|..|....||.|:.|:..:.:||:.:.....
  Fly    58 KAV---HKESSSIVAIKLVPVESDLHEIIKEISIMQQCDSPYVVRYYGSYFKQYDLWICMEYCGA 119

  Fly   274 GSLLDIIKHKMRTSNCKQGVFDEATIATVLKEVLKGLEYFHSNGQIHRDIKAGNILIGDDGTIQI 338
            ||:.||::.:.:|       ..|..|||:|.:.|:||.|.|...:|||||||.|||:..:|..::
  Fly   120 GSVSDIMRLRKKT-------LTEDEIATILSDTLQGLVYLHLRRKIHRDIKAANILLNTEGYAKL 177

  Fly   339 ADFGVSAWLATGRDLSRQKVRHTFVGTPCWMAPEVMEQDHGYDFKADIWSFGITAIEMATGTAPY 403
            |||||:     |:.......|:|.:|||.||||||:| :.|||..|||||.||||:|||.|..||
  Fly   178 ADFGVA-----GQLTDTMAKRNTVIGTPFWMAPEVIE-EIGYDCVADIWSLGITALEMAEGKPPY 236

  Fly   404 HKYPPMKVLMLTLQNDPPTLDTGADDKDQYKAYGKTFRKMIVECLQKEPSKRPTASELLKHAFFK 468
            .:..||:.:.:..|..||:.    .:.|::..   .|...:.:||.|||..|.||:|||:|.|.:
  Fly   237 GEIHPMRAIFMIPQKPPPSF----REPDRWST---EFIDFVSKCLVKEPDDRATATELLEHEFIR 294

  Fly   469 KAKDRKYLTQTLLQSGPSMETRVHKAAKRQPGASGRLHRTVTGEWVWSSEEEDNGGSATGSGTGD 533
            .||.|..|.       |.:|...  |.:.|..|:......:......|...::|         |.
  Fly   295 NAKHRSILK-------PMLEETC--AIREQQRANRSFGGVLAASQAKSLATQEN---------GM 341

  Fly   534 RKHPSSDSDSEDR----PMNRLERADSSDSDREEPSPEITHS---VSSATVTPG---------AP 582
            ::|.:.::..||.    |....|...||.||    :..|.|:   |...|:.||         ||
  Fly   342 QQHITDNAFMEDPGTLVPEKFGEYQQSSASD----ATMIAHAEQGVDEGTLGPGGLRNLSKAAAP 402

  Fly   583 AAAGAGAAQELTAGIAQLPLPSEAAG 608
            |||.:.|        :.|.:|:..:|
  Fly   403 AAASSAA--------SPLDMPAVDSG 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fray	NP_001303449.2	STKc_OSR1_SPAK	191..467	CDD:270787	101/275 (37%)
fray	NP_001303449.2	OSR1_C	613..670	CDD:403428
hpo	NP_001261092.1	STKc_MST1_2	38..293	CDD:132943	104/285 (36%)
		S_TKc	42..293	CDD:214567	101/273 (37%)
		Mst1_SARAH	608..655	CDD:288481
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438559
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840