Protein Alignment fray and gck-3

DIOPT Version :10

• Sequence 1: NP_001303449.2
• Gene: fray / 44233
• FlyBaseID: FBgn0023083
• Length: 707
• Species: Drosophila melanogaster
• Sequence 2: NP_507517.2
• Gene: gck-3 / 190400
• WormBaseID: WBGene00013355
• Length: 596
• Species: Caenorhabditis elegans
• Alignment Length: 596
• Identity: 316/596 - (53%)
• Similarity: 389/596 - (65%)
• Gaps: 77/596 - (12%)

  Fly   126 SQPAINNRRRPGTPPPHTVAPGNGTASSRSMTSIPANLSSNNVAGAATLPGAAAPPEKYTWPNSK 190
            |||:    :.|..|||...:|....|                 |.:|.|.....|.::  ||...
 Worm    64 SQPS----QPPPPPPPQVSSPIAAAA-----------------AASAALVAQLNPADR--WPTEP 105

  Fly   191 DDYELRDVIGVGATAVVHGAYCIPRNEKCAIKRINLEKWNTSMDELLKEIQAMSSCFHENVVTYH 255
            ..|:|.:.|||||||.|..|||:|||||.|||.|||||..||:|||..||||||.|.|.|||:|:
 Worm   106 SAYKLDESIGVGATATVFTAYCLPRNEKVAIKCINLEKCQTSVDELSHEIQAMSQCNHPNVVSYY 170

  Fly   256 TSFVVREELWLVLRLLEGGSLLDIIKHKMRTSNCKQ---GVFDEATIATVLKEVLKGLEYFHSNG 317
            |||:.:||||:|:|||..||:|||:|.|::....:|   ||.||.:|||||:||||||||||.||
 Worm   171 TSFIAQEELWVVMRLLNCGSMLDILKRKVKAIGKEQAQFGVLDEVSIATVLREVLKGLEYFHLNG 235

  Fly   318 QIHRDIKAGNILIGDDGTIQIADFGVSAWLA-TGRDLSRQKVRHTFVGTPCWMAPEVMEQDHGYD 381
            ||||||||||||:.|||||||||||||.||| :|.|||||||||||||||||||||||||..|||
 Worm   236 QIHRDIKAGNILLADDGTIQIADFGVSGWLASSGGDLSRQKVRHTFVGTPCWMAPEVMEQVQGYD 300

  Fly   382 FKADIWSFGITAIEMATGTAPYHKYPPMKVLMLTLQNDPPTLDTGADDKDQYKAYGKTFRKMIVE 446
            |||||||.||.|||:|||||||||||||||||||||||||||:|.|:.|||||||||:|:.:|.:
 Worm   301 FKADIWSLGILAIELATGTAPYHKYPPMKVLMLTLQNDPPTLETNAERKDQYKAYGKSFKTLIRD 365

  Fly   447 CLQKEPSKRPTASELLKHAFFKKAKDRKYLTQTLLQSGPSMETRVHKAAKRQPGASGRLHRTVTG 511
            ||||:|:||||||||||::||||.||:|||..||:::..|:....|.::|:.  |||:|.:...|
 Worm   366 CLQKDPAKRPTASELLKYSFFKKGKDKKYLVHTLIENLASVPVVAHHSSKKV--ASGKLRKDAHG 428

  Fly   512 EW--VWSSEEEDNGGSATGSGTGDRKHPSSDSDSEDRPMNRLERADSSDSDREEPSPEITHSVSS 574
            .|  .:.|.:|                  ||.||           |..|.:||:...:.:.|.|
 Worm   429 NWEFEYDSPQE------------------SDDDS-----------DLEDEEREKKKKKASASAS- 463

  Fly   575 ATVTPGAPAAAGAGAAQELTAGIAQ-LPLPSEAAGEAPP----VNLVLRMRNLRRELHDIRFEFV 634
                 ||.||..||.|   |.|.|. .|...|..|...|    :|:|||:||.:|||:||:|::.
 Worm   464 -----GAGAAGAAGGA---TGGAASGAPSAQEGGGATTPCPETLNMVLRVRNQQRELNDIKFDYT 520

  Fly   635 VGKDTAEGIATELVDAGLVDALDTQPMATHLDQLI---AASATMKTITFQLSSGVQPGEVPDERS 696
            ...||.||||.|||.|.|:|..|...:|.:|.:||   .:.:..::|||.|:|||...|:||||:
 Worm   521 KSADTVEGIAHELVTAELIDCHDLVIVAANLQKLIDFAESKSDRRSITFALNSGVHANEIPDERT 585

  Fly   697 LVGYAQISITD 707
            |.|:||||:.|
 Worm   586 LTGFAQISLLD 596

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fray	NP_001303449.2	STKc_OSR1_SPAK	191..467	CDD:270787	207/279 (74%)
		OSR1_C	613..670	CDD:463491	29/59 (49%)
gck-3	NP_507517.2	STKc_OSR1_SPAK	106..386	CDD:270787	207/279 (74%)
		OSR1_C	499..556	CDD:463491	28/56 (50%)