Protein Alignment Xbp1 and XBP1

DIOPT Version :10

• Sequence 1: NP_726032.4
• Gene: Xbp1 / 44226
• FlyBaseID: FBgn0021872
• Length: 498
• Species: Drosophila melanogaster
• Sequence 2: NP_001073007.1
• Gene: XBP1 / 7494
• HGNCID: 12801
• Length: 376
• Species: Homo sapiens
• Alignment Length: 505
• Identity: 126/505 - (24%)
• Similarity: 181/505 - (35%)
• Gaps: 164/505 - (32%)

  Fly    13 PRTAITSNNLPKLRPAPLTAAL-LKVSATPSASPTPSSSGYASSSNMDDDNMAASQPKAKKR-RL 75
            |:..:.|........||...|| |.|.|...|||..:|.|.               |:|:|| ||
Human    15 PKVLLLSGQPASAAGAPAGQALPLMVPAQRGASPEAASGGL---------------PQARKRQRL 64

  Fly    76 DHLTWEEKVQRKKLKNRVAAQTSRDRKKARMEEMDYEIKELTDRTEILQNKCDSLQAINESLLAK 140
            .||:.|||..|:||||||||||:||||||||.|::.::.:|.:..:       .|...|:.|..|
Human    65 THLSPEEKALRRKLKNRVAAQTARDRKKARMSELEQQVVDLEEENQ-------KLLLENQLLREK 122

  Fly   141 NHKLDSELELLRQELAELKQQQQHNTRCISQSNASAGAEGCASTNLGSAAGYTTGGHTVVSASAG 205
            .|.|..|.:.|||.|.
Human   123 THGLVVENQELRQRLG------------------------------------------------- 138

  Fly   206 GAAEEQQEPGLTLESCGPLPTLQDMLGVDEEFDVKRLEELAESLLADITADLETGAGASSPAAAQ 270
                                  .|.|..:||.:.|..|      :..:....|:.|||
Human   139 ----------------------MDALVAEEEAEAKGNE------VRPVAGSAESAAGA------- 168

  Fly   271 DAGNAERLPGPMVGPAAERLESDGHRANGLNVEQEQETEHKVSLNVQMLKINGNPQHTTAAPASR 335
                     ||:|.| .|.|..|   :.|::   ..::|..:.|.:   ..|.:|......|:..
Human   169 ---------GPVVTP-PEHLPMD---SGGID---SSDSESDILLGI---LDNLDPVMFFKCPSPE 214

  Fly   336 TATI-----TATAAASQLQATPDTVYGTYDAKTNSITIVMDGDAVPVNEAVEEIYCDGVSAGDDS 395
            .|::     ......|.|.|:.....||..||..:|..::..|.:.....|.||    .|..:..
Human   215 PASLEELPEVYPEGPSSLPASLSLSVGTSSAKLEAINELIRFDHIYTKPLVLEI----PSETESQ 275

  Fly   396 TDVIMKCPPPATSPSQVYLNVMNAVDNSDDEESF------DPIDRFLRPRVKAISPLAKS----- 449
            .:|::|......|||:            :|...|      :|::..|.|.: .||.|..|
Human   276 ANVVVKIEEAPLSPSE------------NDHPEFIVSVKEEPVEDDLVPEL-GISNLLSSSHCPK 327

  Fly   450 PALSLHSATSDHGYESILGSPTSVALTLPADEDDFPWESNF-DELFPSLI 498
            |:..|..|.||.||...|...:.::..|..:..   ||..| :||||.||
Human   328 PSSCLLDAYSDCGYGGSLSPFSDMSSLLGVNHS---WEDTFANELFPQLI 374

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Xbp1	NP_726032.4	bZIP_XBP1	81..138	CDD:269839	26/56 (46%)
		coiled coil	84..135	CDD:269839	22/50 (44%)
XBP1	NP_001073007.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	44..93		31/63 (49%)
		bZIP_XBP1	70..126	CDD:269839	29/62 (47%)
		Basic motif. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	72..94		17/21 (81%)
		coiled coil	73..124	CDD:269839	25/57 (44%)
		Nuclear localization signal (NLS), in isoforms 1 and isoform 2. /evidence=ECO:0000269|PubMed:16461360	75..92		14/16 (88%)
		Leucine-zipper. /evidence=ECO:0000255|PROSITE-ProRule:PRU00978	98..133		8/41 (20%)