DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment ND-23 and NDUFS8

DIOPT Version :9

Sequence 1:	NP_524719.1	Gene:	ND-23 / 44207	FlyBaseID:	FBgn0017567	Length:	217	Species:	Drosophila melanogaster
Sequence 2:	NP_002487.1	Gene:	NDUFS8 / 4728	HGNCID:	7715	Length:	210	Species:	Homo sapiens

Alignment Length:	204	Identity:	152/204 - (74%)
Similarity:	167/204 - (81%)	Gaps:	17/204 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 LLAAQRAEPKDIVEVPKG-----------YVYVNNKELSMEFADITDRAASTMFFGELLRGFAVT 78
            |..|.||.|      |.|           |.|||.::..|:...:|||||.|:.:.||.||..:|
Human    13 LAQAARAGP------PGGRSLHSSAVAATYKYVNMQDPEMDMKSVTDRAARTLLWTELFRGLGMT 71

  Fly    79 LAHIFKEPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEERADG 143
            |:::|:||||||||||||||||||||||||||||||||||||||||||||||||||||||.||||
Human    72 LSYLFREPATINYPFEKGPLSPRFRGEHALRRYPSGEERCIACKLCEAICPAQAITIEAEPRADG 136

  Fly   144 SRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEKLLCNGDKWESEIAS 208
            |||||||||||||||||||||||||||||||||||||||||||||||||||||.||||||:|||:
Human   137 SRRTTRYDIDMTKCIYCGFCQEACPVDAIVEGPNFEFSTETHEELLYNKEKLLNNGDKWEAEIAA 201

  Fly   209 NLQADHLYR 217
            |:|||:|||
Human   202 NIQADYLYR 210

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ND-23	NP_524719.1	PRK05888	61..217	CDD:235637	136/155 (88%)
NDUFS8	NP_002487.1	PRK05888	54..210	CDD:235637	136/155 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165147914
Domainoid	1	1.000	120	1.000	Domainoid score	I5784
eggNOG	1	0.900	-	-		E1_COG1143
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1867
Inparanoid	1	1.050	312	1.000	Inparanoid score	I2592
Isobase	1	0.950	-	0	Normalized mean entropy	S2075
OMA	1	1.010	-	-		QHG55295
OrthoDB	1	1.010	-	-		D1283957at2759
OrthoFinder	1	1.000	-	-		FOG0004083
OrthoInspector	1	1.000	-	-		oto90078
orthoMCL	1	0.900	-	-		OOG6_100887
Panther	1	1.100	-	-	LDO	PTHR10849
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2670
SonicParanoid	1	1.000	-	-		X2833
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750