DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spen and MRN1

DIOPT Version :9

Sequence 1:	NP_722615.1	Gene:	spen / 44205	FlyBaseID:	FBgn0016977	Length:	5560	Species:	Drosophila melanogaster
Sequence 2:	NP_015140.1	Gene:	MRN1 / 855917	SGDID:	S000006105	Length:	612	Species:	Saccharomyces cerevisiae

Alignment Length:	645	Identity:	118/645 - (18%)
Similarity:	221/645 - (34%)	Gaps:	209/645 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   454 SYSSSHSSSSS------SHSSSHSHASSPVQSSGNCAMAEGRSSRTVNSVTVTSNSSNPSGTAVT 512
            ||:::::::::      |:::::::...|..||.:.||.:..||......|..|...| .|.||
Yeast     4 SYNNNNNNNNNNNNNNISNNNNNNNMFPPFPSSDDFAMYQQSSSSGPYQETYASGPQN-FGDAV- 66

  Fly   513 VSSAGVGGGCGSSSSSSSSSSSSGSSCLTANPVVHSEDNRPLAIRVRNLPA---RSSDTSL---K 571
                                                   .|:......||:   |..:.|.   .
Yeast    67 ---------------------------------------YPMNGNFTLLPSDFTREPNDSFFYEN 92

  Fly   572 DGLFHEYKKHGKVTWVKVVGQNSERYALVCFKKPDDVEKALEVSHDKHFFGCKIEVEPYQGYDVE 636
            ||:|...:...:.|..:...:|..:...  |.:..:.|...||.|:.:         .|..|:..
Yeast    93 DGIFDYQRIQQQPTQFQTKQRNDSQQQR--FSQEQNFEIDNEVVHNNN---------RYYEYERS 146

  Fly   637 DNEFRPYEAE-----LDEYHP------------------------------KSTRTLFIGNLEKD 666
            .||..|::.|     .|...|                              ..:||:::||:..:
Yeast   147 SNEVSPFDDENPNVLSDGMSPTIMATATAVTNANAPLPVNAQANNPLNFTSAPSRTVYLGNVPPN 211

  Fly   667 ITAGELRSHFEAFGEIIEIDIKKQGLNAY--------AFCQYSDIVSVVKAMRKMDGEHLGSNRI 723
            ::..||..|..: |.:.::.|..:.:.|:        |...:||  :::|.:      ::|...|
Yeast   212 LSVKELLDHVRS-GVVEDVKIIPEKMCAFVSFIDESAALLFHSD--AILKRL------NIGDRDI 267

  Fly   724 KLGFGKSMPTNC---------------------VWIDGVDEKVSESFLQSQFTRFGAVTKVSIDR 767
            |:|:||  ||..                     :.|:|.:..:||..|:.....:|.:..:.|.:
Yeast   268 KIGWGK--PTRIDPIVAARISTDGATRNVYIGRMTIEGEESHLSEEQLRVDLEEYGEIDCIKIIK 330

  Fly   768 NRQLALVLYDQVQNAQAAVKDM--RGTILRRKKLQVDFASRECQDAFYDK-QEKQQQQSSGSNP- 828
            .:.:|.:.:..:.||...|.::  |....:.|:  :.:....|  ||..| |:....|..|..|
Yeast   331 EKGIAFIHFASILNAIKVVTNLPIRNPYYQNKR--IFYGKDRC--AFITKTQQHNAAQFLGVQPG 391

  Fly   829 -----RFSRYESSASSLQSRSRASSFSRHQNNSNDDCSPINTPGGASSGISSASNLINQ-STSIN 887
                 .||..|..:::|..:|.|:             :.|.|..|..:.:.:.:..:.. ...:.
Yeast   392 MEHMIEFSDREFISNALLQQSAAA-------------AAIATSAGGPNNLGNRTVYLGSLPKDVK 443

  Fly   888 ISNIGTNACSAMPAPSLASA----------VVSCNVNASGTVPASTSM----------PSGVSSS 932
            |..|    |:|:....|.|.          |...:..|:....|.:|:          ..|....
Yeast   444 IEEI----CNAVRGGLLQSIKLLNDRYVCFVTFIDPTAAAQFYAMSSLYGFTVQKKRCKVGWGKH 504

  Fly   933 SSSLPMSPAALAQRHRMVRNARQTVDCDFNEVGRLRFRSSEEVSGGAGNSTQFEDVRCDS 992
            |..|| :..|||..:...||.         .||.:.|         .|:|.:.|.|..:|
Yeast   505 SGPLP-NALALAVSNGASRNV---------YVGNIDF---------VGDSLRDERVFTES 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spen	NP_722615.1	RRM2_SHARP	555..628	CDD:240795	14/78 (18%)
		RRM3_SHARP	654..726	CDD:240796	17/79 (22%)
		RRM4_SHARP	727..803	CDD:240797	17/98 (17%)
		RILP-like	1997..>2055	CDD:304877
		SPOC	5404..5527	CDD:285043
MRN1	NP_015140.1	RRM1_MRN1	200..273	CDD:240964	18/81 (22%)
		RRM2_MRN1	289..372	CDD:409943	14/86 (16%)
		RRM3_MRN1	430..503	CDD:240965	11/76 (14%)
		RRM_SF	519..606	CDD:418427	10/45 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7255
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950