DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spen and RBM4B

DIOPT Version :9

Sequence 1:	NP_722615.1	Gene:	spen / 44205	FlyBaseID:	FBgn0016977	Length:	5560	Species:	Drosophila melanogaster
Sequence 2:	NP_113680.1	Gene:	RBM4B / 83759	HGNCID:	28842	Length:	359	Species:	Homo sapiens

Alignment Length:	368	Identity:	79/368 - (21%)
Similarity:	147/368 - (39%)	Gaps:	86/368 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   658 LFIGNLEKDITAGELRSHFEAFGEIIEIDIKKQGLNAYAFCQYSDIVSVVKAMRKMDGEHL-GSN 721
            ||||||.::.|..|:||.||.:|:::|.||.|.    |.|....|..:...|:|.:....| |.|
Human     4 LFIGNLPREATEQEIRSLFEQYGKVLECDIIKN----YGFVHIEDKTAAEDAIRNLHHYKLHGVN 64

  Fly   722 -RIKLGFGKSMPTNCVWIDGVDEKVSESFLQSQFTRFGAVTKVSIDRNRQLALVLYDQVQNAQAA 785
             .::....||..:..:.:..:....:...|:::|..:|.|  :..|..:..|.|..::.::|..|
Human    65 INVEASKNKSKASTKLHVGNISPTCTNQELRAKFEEYGPV--IECDIVKDYAFVHMERAEDAVEA 127

  Fly   786 VKDMRGTILRRKKLQVDFA-------------------------SREC------QDAFYDKQEKQ 819
            ::.:..|..:.|::.|..:                         |:||      :.|.:.:|..:
Human   128 IRGLDNTEFQGKRMHVQLSTSRLRTAPGMGDQSGCYRCGKEGHWSKECPVDRTGRVADFTEQYNE 192

  Fly   820 Q------------------QQSSGSNPRFSRYE-SSASSLQSRSRASSFSRHQNNSNDDCSPINT 865
            |                  ..:.|:...:.||. .|..::.:.:.||:::..:...:      :.
Human   193 QYGAVRTPYTMGYGESMYYNDAYGALDYYKRYRVRSYEAVAAAAAASAYNYAEQTMS------HL 251

  Fly   866 PGGASSGISSASNLINQSTSIN------ISNIGTNACSAMPAPSLASAVVSCNVNASGTVPASTS 924
            |...|:.::|..|    |||::      :.|.|..|.||..|.:.|:.......:.|....|:..
Human   252 PQVQSTTVTSHLN----STSVDPYDRHLLPNSGAAATSAAMAAAAATTSSYYGRDRSPLRRAAAM 312

  Fly   925 MPS-----GVSSSSSSLPMSPAALAQRHRMVRNAR----QTVD 958
            :|:     |....|.   :|.|:.|.|:.:...||    |.||
Human   313 LPTVGEGYGYGPESE---LSQASAATRNSLYDMARYEREQYVD 352

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spen	NP_722615.1	RRM2_SHARP	555..628	CDD:240795
		RRM3_SHARP	654..726	CDD:240796	25/69 (36%)
		RRM4_SHARP	727..803	CDD:240797	14/75 (19%)
		RILP-like	1997..>2055	CDD:304877
		SPOC	5404..5527	CDD:285043
RBM4B	NP_113680.1	RRM1_RBM4	2..68	CDD:410018	25/67 (37%)
		RRM2_RBM4	78..144	CDD:410019	11/67 (16%)
		PTZ00368	<145..>181	CDD:173561	3/35 (9%)
		ZnF_C2HC	161..176	CDD:197667	2/14 (14%)
		Interaction with TNPO3. /evidence=ECO:0000250	196..359		34/170 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910