Protein Alignment spen and Rbm15

DIOPT Version :9

• Sequence 1: NP_722615.1
• Gene: spen / 44205
• FlyBaseID: FBgn0016977
• Length: 5560
• Species: Drosophila melanogaster
• Sequence 2: XP_003749428.1
• Gene: Rbm15 / 684233
• RGDID: 1592713
• Length: 962
• Species: Rattus norvegicus
• Alignment Length: 1229
• Identity: 233/1229 - (18%)
• Similarity: 369/1229 - (30%)
• Gaps: 523/1229 - (42%)

  Fly   426 PTHPIRTRHNLHGRSTTSSSRSHSRSPSSYSSSHSSSS------SSHSSSHSHASSPVQSSGNCA 484
            |..|.|:|    |...:||....|:.......|:.|||      .|..|.|...||....|....
  Rat    52 PVKPKRSR----GGEDSSSRGERSKKLGGSGGSNGSSSGKTDSGGSRRSLHLDKSSSRGGSREYD 112

  Fly   485 MAEGRSSRTVNSVTVTSNSSNPSGTAVTVSSAGVGGGCGSSSSSSSSSSSSGSSCLTANPVVHSE 549
            ...|.||..::|.: :.::.|.||...:.||:..|||...||.::||:...|..      |.:.
  Rat   113 TGGGSSSSRLHSYS-SPSTKNSSGGGESRSSSRGGGGESRSSGAASSAPGGGDG------VEYK- 169

  Fly   550 DNRPLAIRVRNLPARSSDTSLKDGLFHEYKKHGKVTWVKV-----VGQNSERYALVCFKKPDDVE 609
                 .:::..|.::.||.:::||||||:|:.|.|: ||:     .|...||.|.|.|::|:|..
  Rat   170 -----TLKISELGSQLSDEAVEDGLFHEFKRFGDVS-VKISHLSGSGSGDERVAFVNFRRPEDAR 228

  Fly   610 ------------------KALEVSH-------DKHFF---------------------GCKIEVE 628
                              :|:.||.       ||..:                     |.:..:.
  Rat   229 AAKHARGRLVLYDRPLKIEAVYVSRRRSRSPLDKDTYAPSSSVVGSSVGSHRHAPGGGGGQRSLS 293

  Fly   629 P------YQGYDVE---------------------DNEFRPYE---------------------A 645
            |      |:.|.::                     :.::..|:                     .
  Rat   294 PGGAALGYRDYRLQQLALGRLPPPPPPPLPRELERERDYPFYDRVRPAYSLEPRVGAGAGAAPFR 358

  Fly   646 ELDEYHP----KSTRTLFIGNLEKDITAGELRSHFEAFGEIIEIDIKKQG---LNAYAFCQYSDI 703
            |:||..|    ::.||||:|||:..:|..:||..|:.||.|.|:|||:..   .:.|.|.::.::
  Rat   359 EVDEISPEDDQRANRTLFLGNLDITVTENDLRRAFDRFGVITEVDIKRPSRGQTSTYGFLKFENL 423

  Fly   704 VSVVKAMRKMDGEHLGSNRIKLGFGKSMPTNCVWIDGVDEKVSESFLQSQFTRFGAVTKVSIDRN 768
            ....:|...|.|:.:..|.||:|:||:.||..:|:.|:...|..:.|..:|.|||.:..:...:.
  Rat   424 DMSHRAKIAMSGKIIIRNPIKIGYGKATPTTRLWVGGLGPWVPLAALAREFDRFGTIRTIDYRKG 488

  Fly   769 RQLALVLYDQVQNAQAAVKDMRGTIL--RRKKLQVDFASRECQDAFYDKQEKQQQQSSGSNPRFS 831
            ...|.:.|:.:..|.||...|||..|  ..::|:||||         |.:.:.|||.....| .:
  Rat   489 DSWAYIQYESLDAAHAAWTHMRGFPLGGPDRRLRVDFA---------DTEHRYQQQYLQPLP-LT 543

  Fly   832 RYESSASSLQSRSRASSFSRHQNNSNDDCSPINTPGGASSGISSASNLINQSTSINISNIGTNAC 896
            .||....:...|:
  Rat   544 HYELVTDTFGHRA---------------------------------------------------- 556

  Fly   897 SAMPAPSLASAVVSCNVNASGTVPASTSMPSGVSSSSSSLPMSPAALAQRHRMVRNARQTVDCDF 961
               |.|                                               :|:||
  Rat   557 ---PDP-----------------------------------------------LRSAR------- 564

  Fly   962 NEVGRLRFRSSEEVSGGAGNSTQFEDVRCDS-----PVTARQGSAVNCFTGPTAAVGESIDGTLN 1021
            :....|.:|..:            .|:..||     |...|:.||....:..||.  |.:|.
  Rat   565 DRTPPLLYRDRD------------RDLYPDSDWVPPPPPVRERSARAATSAVTAY--EPLDS--- 612

  Fly  1022 NNQITGGAEGFTGSGGSILSRRRCG------KTPKDLHPVHNQRIQLAEQVEECPSSGDEGVVSP 1080
                              |.|||.|      :..:||                 |||.|:    |
  Rat   613 ------------------LDRRRDGWSLDRDRGDRDL-----------------PSSRDQ----P 638

  Fly  1081 RKRIKMDYHHHHHHSNASGVESTGEHSSINKPSPLLLSNCDVIHDPLNRKSEIRRVSETPSGSPS 1145
            |||...:             ||.|.|...:..|              :|..:.|..:.:|..||.
  Rat   639 RKRRLPE-------------ESGGRHLDRSPES--------------DRPRKQRHCTPSPDRSPE 676

  Fly  1146 I-----KFPGHLPSAPQSLMLSCRRPSIDVGALSALSSSSAFRHGIVGASSMDQQHMMNASAAAK 1205
            :     ::......:.:.|:|....|..|             |.|.:..|..|::...|:::|.:
  Rat   677 LSSNRDRYNSDNDRSSRLLLLERPSPVRD-------------RRGSLEKSQSDKRDRKNSASAER 728

  Fly  1206 RRRVTTTMQQPSSSSTTNSSSGSGLGGISSLTPADEYHHHVSRGRGHQLHSHHSHEASGGESADG 1270
            .|:..|.  .|:...|.....                                       :.:||
  Rat   729 DRKHRTA--APTEGKTPLKKE---------------------------------------DRSDG 752

  Fly  1271 SRPGTPLCDERPEVLPTEPRRLPPPRERVRERTRDVMWLPLPKFGVLFFQQQQSRSSGGGGAGNS 1335
            :.|..          .|...:..||.::
  Rat   753 NTPSA----------STSSSKQKPPSQK------------------------------------- 770

  Fly  1336 YLQQQLGGGSTGGLGCIGAASSSACSLNNSSLNASQGMGSCSGSTFLPSPSSRYWRSSSHHQNQQ 1400
                     ..||...:.|:|...|.       |.|||.....|.|          .|:.|..|.
  Rat   771 ---------QDGGTAPVAASSPKLCL-------AWQGMLLLKNSNF----------PSNMHLLQG 809

  Fly  1401 NNHQQQSQQLHGSSSSNTCLMASPARPRSLSSNSSDSDVPGQNAGGSPSLDERLRNFEENYERWS 1465
            :.....|..:.||:......:....|.|.                ..|.|||..|..:      .
  Rat   810 DLQVASSLLVEGSTGGKVAQLKITQRLRL----------------DQPKLDEVTRRIK------V 852

  Fly  1466 GGSSREHISGHTPSSATPSWQLSMHMNLSTGLNSHQTSSASGNSNSSSGTVSSSASNSR 1524
            .|.     :|:....|.|                   .|:...|:|||.|..::||..|
  Rat   853 AGP-----NGYAILLAVP-------------------GSSDSRSSSSSATSDTAASTQR 887

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spen	NP_722615.1	RRM2_SHARP	555..628	CDD:240795	28/123 (23%)
		RRM3_SHARP	654..726	CDD:240796	26/74 (35%)
		RRM4_SHARP	727..803	CDD:240797	23/77 (30%)
		RILP-like	1997..>2055	CDD:304877
		SPOC	5404..5527	CDD:285043
Rbm15	XP_003749428.1	RRM1_RBM15	168..250	CDD:240997	23/88 (26%)
		RRM2_RBM15	366..452	CDD:240999	29/85 (34%)
		RRM3_RBM15	455..527	CDD:241001	22/80 (28%)
		SPOC	789..925	CDD:285043	31/155 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D367857at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820