DRSC/TRiP Functional Genomics Resources

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Protein Alignment spen and RBM15

DIOPT Version :9

Sequence 1:NP_722615.1 Gene:spen / 44205 FlyBaseID:FBgn0016977 Length:5560 Species:Drosophila melanogaster
Sequence 2:NP_073605.4 Gene:RBM15 / 64783 HGNCID:14959 Length:977 Species:Homo sapiens


Alignment Length:835 Identity:186/835 - (22%)
Similarity:297/835 - (35%) Gaps:255/835 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   408 GDILNVAAVLAAAVDNGVPTHPIRTRHNLHGRSTTSSSRSHSRSPSSYSSSHSSSSSSHS----- 467
            ||.|...|.:     .|....|::.:.:..|..:||......:...|..|:.|||..:.|     
Human    36 GDDLRRPATM-----KGKERSPVKAKRSRGGEDSTSRGERSKKLGGSGGSNGSSSGKTDSGGGSR 95

  Fly   468 -SSHSHASSPVQSSGNCAMAEGRSSRTVNSVTVTSNSSNPSGTAVTVSSAGVGGGCGSSSSSSSS 531
             |.|...||....|.......|.||..::|.: :.::.|.||...:.||:..|||...||.::||
Human    96 RSLHLDKSSSRGGSREYDTGGGSSSSRLHSYS-SPSTKNSSGGGESRSSSRGGGGESRSSGAASS 159

  Fly   532 SSSSGSSCLTANPVVHSEDNRPLAIRVRNLPARSSDTSLKDGLFHEYKKHGKVTWVKV-----VG 591
            :...|...            ....:::..|.::.||.:::||||||:|:.|.|: ||:     .|
Human   160 APGGGDGA------------EYKTLKISELGSQLSDEAVEDGLFHEFKRFGDVS-VKISHLSGSG 211

  Fly   592 QNSERYALVCFKKPDDVE------------------KALEVSH-------DKHFF---------- 621
            ...||.|.|.|::|:|..                  :|:.||.       ||..:          
Human   212 SGDERVAFVNFRRPEDARAAKHARGRLVLYDRPLKIEAVYVSRRRSRSPLDKDTYPPSASVVGAS 276

  Fly   622 -----------GCKIEVEP------YQGY--------------------DVE-DNEFRPYE---- 644
                       |.:..:.|      |:.|                    |:| :.::..||    
Human   277 VGGHRHPPGGGGGQRSLSPGGAALGYRDYRLQQLALGRLPPPPPPPLPRDLERERDYPFYERVRP 341

  Fly   645 -----------------AELDEYHP----KSTRTLFIGNLEKDITAGELRSHFEAFGEIIEIDIK 688
                             .|:||..|    ::.||||:|||:..:|..:||..|:.||.|.|:|||
Human   342 AYSLEPRVGAGAGAAPFREVDEISPEDDQRANRTLFLGNLDITVTESDLRRAFDRFGVITEVDIK 406

  Fly   689 KQG---LNAYAFCQYSDIVSVVKAMRKMDGEHLGSNRIKLGFGKSMPTNCVWIDGVDEKVSESFL 750
            :..   .:.|.|.::.::....:|...|.|:.:..|.||:|:||:.||..:|:.|:...|..:.|
Human   407 RPSRGQTSTYGFLKFENLDMSHRAKLAMSGKIIIRNPIKIGYGKATPTTRLWVGGLGPWVPLAAL 471

  Fly   751 QSQFTRFGAVTKVSIDRNRQLALVLYDQVQNAQAAVKDMRGTIL--RRKKLQVDFASRE------ 807
            ..:|.|||.:..:...:....|.:.|:.:..|.||...|||..|  ..::|:||||..|      
Human   472 AREFDRFGTIRTIDYRKGDSWAYIQYESLDAAHAAWTHMRGFPLGGPDRRLRVDFADTEHRYQQQ 536

  Fly   808 ------------CQDAFYDK-------------------------------------QEKQQQQS 823
                        ..|||..:                                     :|:..:.:
Human   537 YLQPLPLTHYELVTDAFGHRAPDPLRGARDRTPPLLYRDRDRDLYPDSDWVPPPPPVRERSTRTA 601

  Fly   824 SGSNPRFSRYESSASSLQSRSRASSFSRHQN-----NSNDDCSPINTP---GGASSGISSASNLI 880
            :.|.|.:...:    ||..|....|..|.:.     :|.|.......|   ||.....|..|:..
Human   602 ATSVPAYEPLD----SLDRRRDGWSLDRDRGDRDLPSSRDQPRKRRLPEESGGRHLDRSPESDRP 662

  Fly   881 NQSTSINISNIGTNACSAMP--APSLASAVVSCNVNASGTVPASTSMPSGVSSSSSSLPMSP--- 940
            .:           ..|:..|  :|.|:|:....|.:...:.......||.:.....||..|.   
Human   663 RK-----------RHCAPSPDRSPELSSSRDRYNSDNDRSSRLLLERPSPIRDRRGSLEKSQGDK 716

  Fly   941 -----AALAQRHRMVRNARQTVDCDFNEVGRLRFRSSEEVSGGAGNSTQFEDVRCDSPVTARQGS 1000
                 :|.|:|.|..|....|       .|:...: .|:.|.|:..||.....:..||...:.|.
Human   717 RDRKNSASAERDRKHRTTAPT-------EGKSPLK-KEDRSDGSAPSTSTASSKLKSPSQKQDGG 773

  Fly  1001 AVNCFTGPTAAVGESI----DGTL---NNN------------QITGG--AEGFTG 1034
                 |.|.|:....:    .|.|   |:|            |:...  .||.||
Human   774 -----TAPVASASPKLCLAWQGMLLLKNSNFPSNMHLLQGDLQVASSLLVEGSTG 823

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spenNP_722615.1 RRM2_SHARP 555..628 CDD:240795 28/123 (23%)
RRM3_SHARP 654..726 CDD:240796 26/74 (35%)
RRM4_SHARP 727..803 CDD:240797 23/77 (30%)
RILP-like 1997..>2055 CDD:304877
SPOC 5404..5527 CDD:285043
RBM15NP_073605.4 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..167 37/136 (27%)
RRM1_RBM15 169..251 CDD:409969 23/82 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 256..298 4/41 (10%)
RRM2_RBM15 367..453 CDD:409971 29/85 (34%)
RRM3_RBM15 456..528 CDD:409973 21/71 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 555..778 43/250 (17%)
SF-CC1 624..>736 CDD:273721 24/122 (20%)
SPOC 781..954 CDD:400205 9/43 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 865..884
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0112
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D367857at2759
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
43.780

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