Protein Alignment spen and PSPC1

DIOPT Version :9

• Sequence 1: NP_722615.1
• Gene: spen / 44205
• FlyBaseID: FBgn0016977
• Length: 5560
• Species: Drosophila melanogaster
• Sequence 2: NP_001035879.1
• Gene: PSPC1 / 55269
• HGNCID: 20320
• Length: 523
• Species: Homo sapiens
• Alignment Length: 476
• Identity: 100/476 - (21%)
• Similarity: 178/476 - (37%)
• Gaps: 121/476 - (25%)

  Fly  1689 TAASSSSPAANSGPTKGLQYPFPSHPPLPNTAAPPPAVQPAPP---PLPEMG-----KQSRLTGQ 1745
            :|...|.|||.:.....|             |..|....||||   |..|||     |.....|:
Human    24 SAVGESEPAAAAAMALAL-------------AGEPAPPAPAPPEDHPDEEMGFTIDIKSFLKPGE 75

  Fly  1746 SS--------GNNLTKSLSVPDGPQ-----SSPARVQLQKSASVPGSTNVGAPSSLSLDSTTASV 1797
            .:        ..||...::..|..:     ..|:.|.:.:....         ..:.|:|
Human    76 KTYTQRCRLFVGNLPTDITEEDFKRLFERYGEPSEVFINRDRGF---------GFIRLES----- 126

  Fly  1798 ETSASISSSTSNGNSSLTSAAIHVQKPQQSTFVEEEHTKKSGTSTSQSSSSSSKKISS--THDKL 1860
            .|.|.|:.:..:|       .|...:|.:..|            .:..::.:.|.:|.  :::.|
Human   127 RTLAEIAKAELDG-------TILKSRPLRIRF------------ATHGAALTVKNLSPVVSNELL 172

  Fly  1861 HSKHNNRSESDKKIKKSDKNASSSDK-----------RK---NSSTSQSSKSATPR--IEDDSSE 1909
            ....:.....:|.:...|....::.|           ||   .........:.|||  |.:...:
Human   173 EQAFSQFGPVEKAVVVVDDRGRATGKGFVEFAAKPPARKALERCGDGAFLLTTTPRPVIVEPMEQ 237

  Fly  1910 ADDTADKAEKNQRHEKEKKERQEKREKDLRKQVEREEKDRKAQQE--EREKEDR-KAKEEEKERE 1971
            .||.....||..    :|.::..|         |||:..|.||..  |.|...| ||.:|.::::
Human   238 FDDEDGLPEKLM----QKTQQYHK---------EREQPPRFAQPGTFEFEYASRWKALDEMEKQQ 289

  Fly  1972 REKKAQEDREKKEREERELREKEQRDKEQKEKEIREKDLREKEQRERDNREKELRDKDLREKEMR 2036
            ||:..:..||.||:.|.|:    :..:.:.:..:..:||..:::..|  |.:|||:::|:::  :
Human   290 REQVDRNIREAKEKLEAEM----EAARHEHQLMLMRQDLMRRQEELR--RLEELRNQELQKR--K 346

  Fly  2037 EKEQREKELHREKDQREREHREKEQSRRAMDVEQEGRGGRMRELSSYQKSKMDIAGEASSLTAID 2101
            :.:.|.:|.||.:::....|||:|:.||    :|||......| :..|:.:|...|...::
Human   347 QIQLRHEEEHRRREEEMIRHREQEELRR----QQEGFKPNYME-NREQEMRMGDMGPRGAI---- 402

  Fly  2102 CQHNKENAMDTIAQGTPGASP 2122
               |..:|......|..|..|
Human   403 ---NMGDAFSPAPAGNQGPPP 420

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spen	NP_722615.1	RRM2_SHARP	555..628	CDD:240795
		RRM3_SHARP	654..726	CDD:240796
		RRM4_SHARP	727..803	CDD:240797
		RILP-like	1997..>2055	CDD:304877	12/57 (21%)
		SPOC	5404..5527	CDD:285043
PSPC1	NP_001035879.1	RRM1_PSP1	81..151	CDD:241030	13/90 (14%)
		Sufficient for paraspeckles localization	125..358		57/277 (21%)
		RRM2_PSP1	157..236	CDD:241033	12/78 (15%)
		NOPS_PSPC1	227..320	CDD:240584	29/109 (27%)
		Sufficient for perinucleolar caps localization and interaction with NONO. /evidence=ECO:0000269|PubMed:16148043	231..358		38/147 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	460..523

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910