Protein Alignment spen and spen

DIOPT Version :9

• Sequence 1: NP_722615.1
• Gene: spen / 44205
• FlyBaseID: FBgn0016977
• Length: 5560
• Species: Drosophila melanogaster
• Sequence 2: XP_004919955.2
• Gene: spen / 549816
• XenbaseID: XB-GENE-493786
• Length: 3488
• Species: Xenopus tropicalis
• Alignment Length: 5394
• Identity: 1031/5394 - (19%)
• Similarity: 1606/5394 - (29%)
• Gaps: 2407/5394 - (44%)

  Fly   439 RSTTSSSRSHSRSPSSYSSSHSSSSSSHSSSH--SHASSPVQS-SGNCAMAEGRSSRTVNSVTVT 500
            |:..:...|.||||      |||.|.:.|...  |.||.|.:| ||:     |..||:.:|.:::
 Frog   230 RAERNYQHSRSRSP------HSSQSRNQSPQRLASQASRPTRSPSGS-----GSRSRSSSSDSLS 283

  Fly   501 SNSSNPSGTAVTVSSAGVGGGCGSSSSSSSSSSSSGSS-----------CLTANPVVHSEDNRP- 553
            |:||.                  ||.||.||||||..|           ...|.|::..:.:.|
 Frog   284 SSSST------------------SSDSSESSSSSSDESPARSVQSAAVPAPPAQPLLSLDKDEPR 330

  Fly   554 --LAIRVRNLPARSSDTSLKDGLFHEYKKHGKVTWVKVVGQNSERYALVCFKKPDDVEKALEVSH 616
              ..|:|:|||.||:|||||||||||:||:||||.|::.|.:.|||.||.|::.:|.||||..|.
 Frog   331 KSFGIKVQNLPVRSTDTSLKDGLFHEFKKYGKVTSVQIHGVSEERYGLVFFRQQEDQEKALNASK 395

  Fly   617 DKHFFGCKIEVEPYQGYDVE-DNEFRPYEAELDEYHPKSTRTLFIGNLEKDITAGELRSHFEAFG 680
            .|.|||.:|||..:.|.:.| :|||||.:..:||:|||:|||||||||||..|..:|.:.|:.||
 Frog   396 GKLFFGMQIEVTAWVGPETESENEFRPLDERIDEFHPKATRTLFIGNLEKTTTHLDLHNLFQRFG 460

  Fly   681 EIIEIDIKK-QGLNAYAFCQYSDIVSVVKAMRKMDGEHLGSNRIKLGFGKSMPTNCVWIDGVDEK 744
            ||::||:|| .|:..|||.|||||.||.||::|||||:||:||:|||||||||||||||||:...
 Frog   461 EIVDIDVKKVNGVPQYAFLQYSDIGSVCKAIKKMDGEYLGNNRLKLGFGKSMPTNCVWIDGLSSN 525

  Fly   745 VSESFLQSQFTRFGAVTKVSIDRNRQLALVLYDQVQNAQAAVKDMRGTILRRKKLQVDFASRECQ 809
            ::|.:|...|.|:|.|.||..||.:.:|||||::::.||||||:.:|..:....::||||::|.|
 Frog   526 ITEQYLTRHFCRYGPVVKVVFDRFKGMALVLYNEIEYAQAAVKETKGRKIGGNDVKVDFANQESQ 590

  Fly   810 DAFYDKQEKQQQQSSGSNPRFSRYESSASSLQSRSRASSFSRHQNNSNDDCSPINTPGGASSGIS 874
            .|||...|     |||.:.| ..|:..:......||..|:....:........:.|||
 Frog   591 LAFYGSME-----SSGQDIR-DFYDIISERRTDESRRGSYHEFTSAERTYYETVRTPG------- 642

  Fly   875 SASNLINQSTSINISNIGTNACSAMPAPSLASAVVSCNVNASGTVPASTSMPSGVSSSSSSLPMS 939
                                                                             
 Frog   643 ----------------------------------------------------------------- 642

  Fly   940 PAALAQRHRMVRNARQTVDCDFNEVGRLRFRSSEEVSGGAGNSTQFEDVRCDSPVTARQGSAVNC 1004
                                                       |..|:.|.:.|..:|:     .
 Frog   643 -------------------------------------------TYQEESRREYPTRSRE-----L 659

  Fly  1005 FTGPTAAVGESIDGTLNNNQITGGAEGFTGSGGSILSRRRCGKTPKDLHPVHNQRIQLAEQVEEC 1069
            :|.     .|:..|
 Frog   660 YTD-----WETYQG--------------------------------------------------- 668

  Fly  1070 PSSGDEGVVSPRKRIKMDYHHHHHHSNASGVESTGEHSSINKPSPLLLSNCDVIHDPLNRKSEIR 1134
                             |::...::.:|.      |:.....|..      ..|.:...|:.|..
 Frog   669 -----------------DFYEQRYYDDAR------EYREYRDPYE------QDIREYSYRQRERE 704

  Fly  1135 RVSETPSGSPSIKFPGHLPSAPQSLMLSCRRPSIDVGALSALSSSSAFRHGIVGASSMDQQHMMN 1199
            |..|        :|                                        .:..|:.|
 Frog   705 RERE--------RF----------------------------------------ETERDRDH--- 718

  Fly  1200 ASAAAKRRRVTTTMQQPSSSSTTNSSSGSGLGGISSLTPADEYHHHVSRGRGHQLHSHHSHEASG 1264
                  .||.|...|.|:.:....|.:||
 Frog   719 ------ERRQTERSQSPTHTRRPQSPAGS------------------------------------ 741

  Fly  1265 GESADGSRPGTPLCDERPEVLPTEPRRLPPPRERVRERTRDVMWLPLPKFGVLFFQQQQSRSSGG 1329
                                 |::..|:....||                      :..||||..
 Frog   742 ---------------------PSQSERVASDPER----------------------KIYSRSSDR 763

  Fly  1330 GGAGNSYLQQQLGGGSTGGLGCIGAASSSACSLNNSSLNASQGMGSCSGSTFLPSPSSRYWRSSS 1394
            .|                           :||             |.|.|.|.....:|..|...
 Frog   764 SG---------------------------SCS-------------SLSPSRFDKLDKARAERYGK 788

  Fly  1395 HHQNQQNNHQQQSQQLHGSSSSNTCLMASPARPRSLSSNSSDSDVPGQNAGGSPSLDERLRNFEE 1459
            ..:.:::...:..:             |....||...|:.::.|.|           ||.:...:
 Frog   789 GEKTEKDRSFESER-------------ADKRPPRKEKSDKTEKDKP-----------ERTKRKSK 829

  Fly  1460 NYERWSGGSSREHISGHTPSSATPSWQLSMHMNLSTGLNSHQTSSASGNSNSSSGTVSSSASNSR 1524
            |               |:|||                     .||.:...|....::....||::
 Frog   830 N---------------HSPSS---------------------QSSETDQENEKEASLEKQRSNTK 858

  Fly  1525 HKFLDIDELQPSDIVKSVLAKKSVFDDDFQRLNKNQWYDPSSSDFALGSSSNIVTGSSLVANVSR 1589
                     ||:         |...|.|
 Frog   859 ---------QPA---------KEKNDKD------------------------------------- 868

  Fly  1590 HPGGPCSGNTSPALPNLAATKATPIIGNCSGGLGNSTGSKSAGLLQRLSSLSPMNSPQASMSPYN 1654
                ..|.|....:|.:..|:                                :|..:..:  ::
 Frog   869 ----ATSKNRLDLMPCVVLTR--------------------------------VNEKEGKV--FD 895

  Fly  1655 SPSPSPSVGGVTACLGQLTKPAAPGTASAGLSGGTAASSSSPAANSGPTKGLQYPFPSHPPLPNT 1719
            ||....:|                              .|.|...|
 Frog   896 SPVLEKAV------------------------------KSKPENES------------------- 911

  Fly  1720 AAPPPAVQPAPPPLPEMGKQSRLTGQSSGNNLTKSLSV--------PDGPQSSPARVQLQKSASV 1776
            ...||..|.|..|..:..|..::..::..|.:.|...:        .||.|.....:::::.|.
 Frog   912 VKSPPVDQKALIPRLDQLKTDQVKSETVRNKVPKEKVLASHVEVVDKDGKQKVKKHLKVEQPAE- 975

  Fly  1777 PGSTNVGAPSSLSLDSTTASVETSASISSSTSNGNSSLTSAAIHVQKPQQST--FVEEEHTKKSG 1839
                  || ||..|:...|.....|              .|.:...:|:..|  .::||
 Frog   976 ------GA-SSADLEKLEARKRRFA--------------DANLKCDRPKFETRRSIQEE------ 1013

  Fly  1840 TSTSQSSSSSSKKISSTHDK----LHSKHNNRSESDKKIKKSDKNASSSDKRKNSSTSQSSKSAT 1900
                :.:...|||:.:...:    |....:.|..|.|::.|.|.....:::....::.:..:.:.
 Frog  1014 ----EDARVCSKKLDAVSSRDVTVLKDGESERKGSRKELSKRDIRKIKTERPFTVNSPKDGQESL 1074

  Fly  1901 P--------------RIE--DDSSEADDTADKAEK--NQRHEKEKKERQEKREKDLRKQVERE-- 1945
            |              .:|  |:..|:.:|:.|...  .|||    .:..|..:|:|.|...|:
 Frog  1075 PLGAGIRPNLDVQSRLVEPVDEQFESSETSTKKASVVKQRH----MQLSEDADKELLKDDNRKMY 1135

  Fly  1946 ------EKDRKAQQEEREKEDRKAKEEEKEREREKKAQEDREKKEREERELREKEQRDKEQKEKE 2004
                  ...|:....||.:.:.|...:....:..:|..|...||::.|.|:.:.|:.....||.:
 Frog  1136 CPPPPPPPPREMIGMERSETEEKLAIDIDYTQSYRKQMEQNRKKQQMELEILKSEKFGSPNKETD 1200

  Fly  2005 IREK-----DLREKEQRERDNREKELRDK-DLREKEMREKEQREKELHREKDQREREHREKEQSR 2063
            ..|:     ::.:..|...|:.....:.| ||.|.|:..|.:|.....|: ...|.|......|.
 Frog  1201 EYERRSLVHEVGKPPQDVTDDSPPSKKKKTDLVEFEINTKRERNYRSSRQ-ISNESERTPCSPSV 1264

  Fly  2064 RAMDVEQEGRGG-----RMRELSSYQKSKMDIAGEASSLTAIDCQHNKENAMDTIAQGTPGASPS 2123
            |.....::...|     .|:|:.  :.:|:|      ..|.......||.....|
 Frog  1265 RPFPFHEDEEAGFPQVITMKEIK--ESAKVD------EKTTFPHPPIKEEPFKLI---------- 1311

  Fly  2124 TPSDNTPKERSR-----KLSRNSPVRLHK-RRLSSQESNHSAGGGGSCGGSSHQIHHEDYVKRIR 2182
             ||::..||:..     |:...||...:| .....||.|..     ..|..|:.:..|...||.|
 Frog  1312 -PSESIKKEQMAEPNKCKMPVMSPEEEYKWDSQVKQECNRV-----DIGFPSNLVKRESIRKRSR 1370

  Fly  2183 MENSQNISVHSSNQRLNDRRDSKEHKSSSFKEDKNSSSHISRPHGCGGSSASSSKHHHRRDKHHQ 2247
            ......:.        :|..|..:|||:|                               .||
 Frog  1371 DLEPGEVQ--------SDSDDESDHKSNS-------------------------------PKH-- 1394

  Fly  2248 KGSASSIETNSSIEVVVDPISQTKHNLNTSEEELQSHQPKREKEREHFSSHANSSSSRHKSKRDH 2312
               ||.:|:           |:....|..|||:|        :|||.     ..|||..|:
 Frog  1395 ---ASILES-----------SRFSFLLRGSEEKL--------REREE-----RISSSLEKN---- 1428

  Fly  2313 HHHREKKRHSVAESTNTDEEHTPQQHNPHRRISAAGSGSAGELSSAATNTSSGKLHHQHHRRSVE 2377
                  |.:|.|    .|:..||
 Frog  1429 ------KFYSFA----LDKTITP------------------------------------------ 1441

  Fly  2378 RKSSRGSDEGHHSSSKSLRAKLMMLSSADSDDTD--DASKKHSIFDIPDDCPNVSMYDKVKARSC 2440
                         .:|:|..:...|||:..::..  |..::.:.|.        |..||||..|.
 Frog  1442 -------------DTKALLERAKSLSSSREENWSFLDWDQRFANFR--------STKDKVKVDSA 1485

  Fly  2441 KNMQRQAEEKKIKAKFSQLKQSRAKKKRSTSYDGDSDTEFEDRQHRNSGSSSFHGRY-------- 2497
                    .:.|.:.:.:      |||..|..||.||.:.|.::........|..|:
 Frog  1486 --------PRPIPSWYMK------KKKIRTDSDGKSDDKKEHKEEEQEKQELFASRFLHSSIFEQ 1536

  Fly  2498 -----PGLSSSDDDDD---EETHQRRISSDSDAEHGGQDNQGASTLADANR------------VR 2542
                 ..|...|||.|   ...|.|:.|.|           |.|:..|..:            :.
 Frog  1537 DSKRLQHLEKKDDDTDISLVRPHWRQFSFD-----------GTSSAPDLVQEPVVLFHSRFIELT 1590

  Fly  2543 QMQQNLRRLCDGDDSSEDEIRRNVMKHSHFGKRNSNSTRIASDSESQSQPAPDLTIKQEHPIAPA 2607
            :|||..:...:....:|.:..:.|...|......:....:.|...|...|||...:.|..|:.||
 Frog  1591 RMQQKEKEREESPKETEKQEEKEVQPKSPDPVPENKDHELKSPLTSVPTPAPPAPVSQPEPLPPA 1655

  Fly  2608 QE-------------IKREQLSD------EEQKFKSRHDSNS-----------SIEERKL----- 2637
            .:             :|.|:.::      ||.|......|.|           .:||..:
 Frog  1656 VDKLVPDKAPPDVPTVKEEKPAEPVEPAPEEPKPAPVPASVSLDQPVPPEPVQVVEEVSVLPAPS 1720

  Fly  2638 KTEREIKTELGDFYNSSEYTYTGKLKEYSPETRKKHKKSKRRLKSSSTADTSAAQ-TPLVMTPL- 2700
            ..|..:..||..:.::...|......|....:..:.:.|.:..|.....|....: :|:|.|.:
 Frog  1721 APEDVVPEELPSYLDTKPPTPGASFSETPSNSITEMESSTKPAKMVEETDLQEDKPSPVVSTDIV 1785

  Fly  2701 --TPSIF-DVHS-SSECKTKFDNFDDLKTECSSIPLEISAGERRKHKERKEKKREKLRNMTEATV 2761
              ||.:. |... .||..|:.:|         |.|:             |:||..|.|   .|..
 Frog  1786 CQTPDVVPDAQPLGSENDTEAEN---------STPV-------------KDKKTYKSR---RANA 1825

  Fly  2762 PNSPTTNDTSSEKLSKEERHRLKKSKKSKSMDNSCNTKIYNSSGAHPSTSPSLPATPTSAPSTAQ 2826
            .:.|.|.  .|.::.:|:|:|                          ||||           ..:
 Frog  1826 ADKPATR--KSVRIDREKRNR--------------------------STSP-----------RGE 1851

  Fly  2827 TSKRGEDKMEFIFGIISDEEESQFPEQAETNKDIIPSSVSTTGPIVSAALQTYKQEPSTPNSKNE 2891
            |.|..|.|.|              ||:...|....||||:          :....|||.|.::..
 Frog  1852 TPKHLEVKSE--------------PERGSRNAAKSPSSVA----------EPESSEPSLPLARTR 1892

  Fly  2892 EAHI------------QLTVHEPEQQQQLERSRLSGGSSSSSHADRERHRREKREKKRREKSQRE 2944
            ..::            |..|.|||..:...:......:.:.:....:|.|..|..:|..|:....
 Frog  1893 RRNVRSIYATTGDNDTQAAVKEPETPRSTRKRLEKEPTETPAVVPNKRGRPPKVRRKTGEEVSPI 1957

  Fly  2945 QQNQIHQKSSKVETKVDDDNSVDMDEAGRALEAQLMSDFDTKPIS---------EEATPSTAATY 3000
            :...:.|:....|:| |...|:...|..|:...|.::.   .|:|         .|..|...|:.
 Frog  1958 KAEALKQEPEDTESK-DSTESIKPTEGWRSPRTQKLAH---SPVSSGQQGKKGKNEPRPLQDASG 2018

  Fly  3001 RSDMTDVFRFSDNEDNNSV-----DMTKQGVKSEQ---QEQHKSKDKKK------------KKKR 3045
            .|          |||:|.:     |..||.:..|:   :|:|:.|::..            .:|:
 Frog  2019 ES----------NEDSNEISEPIEDCNKQRLGKEETFVEEKHEQKEEVADGCPAENTTVDISEKK 2073

  Fly  3046 SKEEKQEKLLQQQRRESLPNVASTSSAPPTPGKLTVNVQAASKHADLQLDAKHISSP--PVCKPS 3108
            ::.||..|          |......:|.|.         ...|..:::|:...:...  |...|.
 Frog  2074 NRLEKNSK----------PKGGRPKNAKPV---------VRLKGIEIRLNVDEVKGAMRPAEDPE 2119

  Fly  3109 PSL--PCLI-GDDDDDALHTPKAKPTTPSSRGNDGLTPSREKPRLISPI-----PKTPTIANSST 3165
            |::  |..| ....|||     |.||.|    |...|...|.|...:|.     |:...:|....
 Frog  2120 PTVVSPVKIKSPQKDDA-----AAPTFP----NQSETTFPENPDKDNPAGPKLSPEAAQLARQME 2175

  Fly  3166 LSTQSAETPVSSGTVISSSALATTPTSSTAAGVSAAPGLDNSPTSASAQCKKKESFIPGFDGQLD 3230
            |     |..|.:...|:.:              :|.|...::..|...:.:.:|      ||
 Frog  2176 L-----EQAVENIEKITET--------------TAVPAYKDAQGSEVPETRSEE------DG--- 2212

  Fly  3231 DRISESAVQSISAEFNSTSLLDNIADEPKIPVAS--PP--RATKPLDKLEESKSRVTISQE---E 3288
            |:.:..|.::..|....:.:.|...|....|.|.  ||  ..|.|.|....:.......::   |
 Frog  2213 DKPAHQASETELAAAIGSIIYDISTDAESFPAAPTYPPERETTVPTDSAAAAVPNAAQPEQMEPE 2277

  Fly  3289 TESAVSALLGESF--GTSSTTDYSLDGMDEMSSVNELETPTLVIAE--PDEEAALAAKAIETAGE 3349
            |:.||:.:||.:.  ||.||...:|             ||..:..|  ..:||.::......:.:
 Frog  2278 TDQAVNIILGTNATPGTESTASTTL-------------TPNPLAPESTDSKEADISFSESSNSAQ 2329

  Fly  3350 PASILEEPEMEPEREAEPDPDPEAEIESEPVVEVLDPEELNKAVQSLKHEDMMDIKADTPQSERD 3414
                    |.||.||||..|                           ||         ||:
 Frog  2330 --------EAEPSREAETLP---------------------------KH---------TPR---- 2346

  Fly  3415 LQIDTDTEENPDEADSSGPSLKIDETVQSSSSPEKSISNNSPTPRETANIDIPNVESQPKLSNES 3479
                   ::.|......||..|..|.| .:||.|:...:.||...|...:    .|.|    .|.
 Frog  2347 -------KKMPRHRSRRGPPSKKAEVV-GTSSLEQDNQSQSPVKEEKVKL----AEGQ----KEK 2395

  Fly  3480 TPQPSVITKLPFLDTPKTVPAGLPPSPVKIEPPTISKLQQPLVQPVQTVLPAPHSTGSGISANSV 3544
            |.:|:               |.|.|.            |||| :|             |:|::|.
 Frog  2396 TSEPT---------------AALNPE------------QQPL-EP-------------GLSSSSQ 2419

  Fly  3545 INLDLSNVISSCSNTSAASATASASASISFGSPTASQNAMPQASTPKQGP------ITPQQAIRT 3603
            .|                             .|...::..|......|.|      ...|.:.:.
 Frog  2420 DN-----------------------------DPEFKEDRSPVLKNAIQSPQPLLIDDVSQTSFKL 2455

  Fly  3604 QSLIMQPPTISIPEQTPHFAVPQMVLSPQSHHPQQPGTYMVGIRAPSPHSPLHSPGRGVAQSRLV 3668
            :|....|| :|.|..:|               |.||||                ||: :..|.|.
 Frog  2456 RSSTENPP-VSPPVSSP---------------PLQPGT----------------PGK-LPTSVLT 2487

  Fly  3669 GQLSPVGRPM-------------VSQPSPQQQVQQTQQQHALITSPQSSNISPLASPTTRVL--- 3717
            ..||.....:             :|.|.|           ||..:.::|::...:|...::|
 Frog  2488 STLSHSSTSIMPEWMSRHEDSNTISTPPP-----------ALPPNTKASDVDTSSSTLRKILMEP 2541

  Fly  3718 ---SSSNSPT--TSKVNSYQPRNQQVPQQPSPKSVAEVQTTPQLMTIPLQKMTPIQ-----VPHH 3772
               |||::||  ||.::           :|...|:||..|.|     ||:.:.|:.     ||
 Frog  2542 KYISSSSTPTIVTSAIS-----------EPVSASLAEEPTHP-----PLEAIKPVSEEKSAVP-- 2588

  Fly  3773 PTIISKVVTVQPQQATQSQVASSPPLGSLPPHKNVHLNAHQNQQQPQVIAKMTAHQHQQHMQQFM 3837
              :|:.||               ||....|..          |::..::|
 Frog  2589 --LINAVV---------------PPAAEAPVF----------QEKVTIVA--------------- 2611

  Fly  3838 HQQMIQRQQHMQQQQLHGQSQQITSAPQHQMHQQHQAQQQQQHHNQQHLNQQLHAQQHPTQKQHQ 3902
                                                                             
 Frog  2612 ----------------------------------------------------------------- 2611

  Fly  3903 AQQQFNQQIQQHQSQQQHQVQQQNQAQQQHLSQQQHQSQQQLNQQHQAQQQQLQQIQKLQQMHGP 3967
                                                                             
 Frog  2612 ----------------------------------------------------------------- 2611

  Fly  3968 QQQQKSPQGVGHLGGSTSIFASQQHNSQLPARGVPQQ-------QHPQQLSHSSPCKPNTLVSVN 4025
                  |:       :||:.      |::|....|::       :||.|:..::||.|:..:...
 Frog  2612 ------PK-------ATSVI------SRMPLSFDPEEMPRITLAKHPPQIPSAAPCIPSQKIKQR 2657

  Fly  4026 QGVQPPAILTRVGSHSQPNQQQQLPHQQSSSGHPHQKQLSSPGANLPLQTPLNVIQNTPKIIVQQ 4090
            |.:.                                      .:...::..:::|::.
 Frog  2658 QNIN--------------------------------------DSRTCMKPAMSIIEDR------- 2677

  Fly  4091 HIVAQNQVPPPQTQGNAIHYPQNQGKDSTPPGHVEPTPAMSAQKTSESVSVIRTPTPTTGLAVIS 4155
                                          |....|:|.:..|.:...|.:..:...|.|...||
 Frog  2678 ------------------------------PSETGPSPGLRVQTSQGVVLLSYSGQKTEGPQRIS 2712

  Fly  4156 ANTVGSLLTEENLIKISQ-PKQDELIEQDSKEVDSDYWSAKEVNIDSVIKKLDTPLASKDAKRAV 4219
            |             |||| |..                ||.::.|...:           :|..:
 Frog  2713 A-------------KISQIPPA----------------SAVDIEIQQSV-----------SKTQI 2737

  Fly  4220 EMQAIAPAPIPNPQPGNQSMAQETALPTTSMSVNNSNDHDTEDETETRQLPPAKPPIPTVGRPPG 4284
            :.:.:.|:.|
 Frog  2738 KQEPVTPSQI------------------------------------------------------- 2747

  Fly  4285 RGGSAKRGRQPRGAKKVGGFPLNSVTAAPPGVDSLVVQPGDNGVQTRLRKPVTAPVTRGRKGRPP 4349
                     .|:|.:..|||..:|:.|               |.|.....||.:.:.:
 Frog  2748 ---------LPKGPQTPGGFSAHSLVA---------------GSQPFNASPVISSIKQ------- 2781

  Fly  4350 RNLLLQQQQLQQQQLDIQRKGMEMVTSATSSTPLPTPIPTSSVLTAAEKKARNQALTQAQEQNQV 4414
                             :|..||                          ||.:..::.|
 Frog  2782 -----------------ERSSME--------------------------KAESSHVSNA------ 2797

  Fly  4415 ASQVGTGQDIYEFHEDGGEEPKPKTISSVAPSAEDQRPRLILTINKTQPSIKNISEMEQTIQQQQ 4479
            :||:|.                                  :..:.:|.|.:
 Frog  2798 SSQLGA----------------------------------VKVLTQTNPPV-------------- 2814

  Fly  4480 QQQSEVISNTDPIGGDNSESCNTRKSRRLQEKEDRSTVDDIIEDVVRNTNTPTGTGPH---LPKG 4541
            ...|::::::..|....:||                       .|::.||...|..||   ....
 Frog  2815 LMHSQMVTSSKKITDAKAES-----------------------KVLQPTNLSPGLSPHHSSFSGK 2856

  Fly  4542 AQTPPRRSGRNAQAKKTDAVQIINAVGRPRRSKDRKTIGEQTANLIEEVTASNATVAASHLAPPE 4606
            .|:.|...|..|.....|.       |.|..|            ::::              .|.
 Frog  2857 LQSEPNHVGSGASTPSADR-------GLPHLS------------IVKQ--------------EPH 2888

  Fly  4607 GAGVESHVPQLDAKEVEPVSVVTPISTPAPVSVAAPVTVPVPAMVPVKPTMPQHPKKKAIAAAEI 4671
            ...|..|.|             :|...|...||
 Frog  2889 SPSVAGHSP-------------SPFGRPCHPSV-------------------------------- 2908

  Fly  4672 ESYQAINSSIPSGGLPMHQTAAPATQKITGGVADAVSKALVDPVTGVITAGMPQGKEGNLPAATA 4736
                               ||:|               ||.:..:.::.||||
 Frog  2909 -------------------TASP---------------ALTNNASVMLAAGMP------------ 2927

  Fly  4737 AAPANSSNEDGQAAPPPQLQHQQQQQHPQQPPQQQANLQINTTLIPSGLPNPITALGKSVQLETS 4801
                         .||     .....||:|           |.::|   |:.:|
 Frog  2928 -------------VPP-----YMSSMHPEQ-----------TVIMP---PHSVT----------- 2949

  Fly  4802 AAALLNKPVSVLVKGNASQVIQQQQPQIVAPAKQPIILQQNPLPTVLH----HAQHTTVRPPQPL 4862
                  :|||:   |:.||              ..:.:...|||.:.:    .|.|:.....||
 Frog  2950 ------QPVSL---GHLSQ--------------GDVRINTPPLPAMQYAIRPEALHSPRAAMQP- 2990

  Fly  4863 KAHVLNREKNIQQQLTPTKQAVAQPPQHAPHSGHMLLTDTAGNQQLVQPQIIARHLQQQQ-HLQV 4926
                       |....|.:....||               |.|:::|.|.:.::|.|.:. |...
 Frog  2991 -----------QLDARPQRSTTPQP---------------AANREMVLPTMSSQHPQDEDVHYHH 3029

  Fly  4927 NVPPPTAH-SPH------SPRIPSQQQQLGPGASISPQQQQPQTVVIKQAASAAQPQILHVVSSK 4984
            .:|..:|| .|.      ..|||:...:|.|        ..||.||:.:       .:..::.|.
 Frog  3030 PIPRGSAHVQPDMLVMQTEYRIPASGMRLDP--------YVPQDVVLPR-------DVRMIMHSH 3079

  Fly  4985 ASVV----PQPQQQQLPPTSSTGPHLQLAKPNYSYAPTVLTPTLPAVQQQQQQHLYKQNNQQKGA 5045
            .:.|    |:|:|.:.|......|            ||..||. |.....:|..:.:.::....|
 Frog  3080 MTAVGEHHPEPRQSRTPEGLVKTP------------PTSKTPQ-PVKDLAKQPDVKRSHSPHNDA 3131

  Fly  5046 QI-QMPPHGIIMPTHPGMLLQQKLPAHLQPQQHQLNPSPPPGKPNPVLHGLQSGQIMPGSVGSPP 5109
            :| .:||.|                         ||.||
 Frog  3132 RILGVPPSG-------------------------LNMSP-------------------------- 3145

  Fly  5110 PVSAAVLKTAQQQVNSVVPVAGIRTAIPNISPQSQPRVSPLVLPPGISGVPPFDASLHDLGAYVS 5174
                           |||...|:                ||:.|||        :|..|.....|
 Frog  3146 ---------------SVVVPHGV----------------PLIHPPG--------SSFRDYRPVYS 3171

  Fly  5175 GRRTQSPPP-AHQQASPITPNDSTYRGVTASRDFMLYQHHLMRGGDYDDKMGSSPPLELRRPGSG 5238
            ..|...|.| .|.|.|..:......|.:|.|:          .||:.:.
 Frog  3172 DIRNYHPAPLPHPQYSSASSIGLHTRSLTPSQ----------VGGEGEH---------------- 3210

  Fly  5239 PPRTIAVPHSLQSPQDRTAADSPQMAQVYVHNTRIPPAHFSEIASRGLYDSGALQLEPPPAHRPT 5303
                   .|:.|:.:.:|    ||::|    :.::||...:|..........:.|:|....|.||
 Frog  3211 -------THANQTGRSKT----PQVSQ----DPKVPPTSVNEQTHHPAIKRHSGQMESHIQHLPT 3260

  Fly  5304 ATISVVVPQQMPAVSSGSPFIGRDGSVQPGSHHHPGKAMDMQLDEMDRMSMIAAVVQQQQEHLPP 5368
            :..|...|.   |:|..:..        |.||         |...:.:.:|..:         .|
 Frog  3261 SQASYPSPS---AISMKAEL--------PSSH---------QSQALQKQAMCLS---------SP 3296

  Fly  5369 ALPAGMELASQQAPPAMAPPPGD-SLVTLLQRYPVMWQGLLALKTDQAAVQMHFVHGNPNVARAS 5432
            |:.:.:.....|:||...||... .:|.||.:||::||||||||.|.||||:|||.||..:|..|
 Frog  3297 AISSTLSRTELQSPPKQEPPHRSVDMVQLLTKYPIVWQGLLALKNDTAAVQLHFVSGNNVLAHRS 3361

  Fly  5433 LPSLVETNTPLLRIAQRMRLEQTQLEGVAKKMQVDKEHCMLLALPCGRDHADVLQHSRNLQTGFI 5497
            ||:  ....|.||||||||||.|||:|||::|.|:.::|:|||||||||..||:..:.:|:..||
 Frog  3362 LPA--PEGGPPLRIAQRMRLEATQLDGVARRMMVESDYCLLLALPCGRDQEDVVNQTESLKAAFI 3424

  Fly  5498 TYLQQKMAAGIVNIPIPGSEQAAYVVHIFPSCDFANENLERAAPDLKNRVAELA-HLLIVIATV 5560
            ||||.|.||||:|:|.|||.|.|||:.|||.|:|:..:|.|.||||...::.:: ||:||||:|
 Frog  3425 TYLQAKQAAGIINVPNPGSNQPAYVLQIFPPCEFSESHLSRLAPDLLASISNISPHLMIVIASV 3488

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spen	NP_722615.1	RRM2_SHARP	555..628	CDD:240795	44/72 (61%)
		RRM3_SHARP	654..726	CDD:240796	45/72 (63%)
		RRM4_SHARP	727..803	CDD:240797	37/75 (49%)
		RILP-like	1997..>2055	CDD:304877	14/63 (22%)
		SPOC	5404..5527	CDD:285043	75/122 (61%)
spen	XP_004919955.2	RRM1_SHARP	7..81	CDD:409784
		RRM2_SHARP	334..407	CDD:409785	39/75 (52%)
		RRM3_SHARP	434..507	CDD:409786	43/73 (59%)
		RRM4_SHARP	508..584	CDD:409787	43/75 (57%)
		PTZ00121	<614..1243	CDD:173412	62/628 (10%)
		pneumo_PspA	1794..>2173	CDD:411490	71/395 (18%)
		Herpes_BLLF1	<2511..3021	CDD:282904	107/560 (19%)
		SPOC	3328..3488	CDD:400205	29/178 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	192	1.000	Domainoid score	I3162
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	613	1.000	Inparanoid score	I892
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D367857at2759
OrthoFinder	1	1.000	-	-		FOG0006265
OrthoInspector	1	1.000	-	-		oto105378
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	5.060