Protein Alignment spen and si:ch1073-335m2.2

DIOPT Version :9

• Sequence 1: NP_722615.1
• Gene: spen / 44205
• FlyBaseID: FBgn0016977
• Length: 5560
• Species: Drosophila melanogaster
• Sequence 2: XP_005170404.1
• Gene: si:ch1073-335m2.2 / 322667
• ZFINID: ZDB-GENE-081104-82
• Length: 3139
• Species: Danio rerio
• Alignment Length: 5525
• Identity: 1062/5525 - (19%)
• Similarity: 1582/5525 - (28%)
• Gaps: 2605/5525 - (47%)

  Fly   218 LKSSGGSGNAGASAAVGFTMSSSPINHHPHQHPHLQNPQHPHYTSSPVVGAGSCPSAAQGQPQIQ 282
            |:..|..|  |.:|.|.|....|....|...:..........|..     .||.|||.:|   ::
Zfish    38 LRKRGSEG--GVAAFVDFVDIKSAQKAHNAVNKMGDRDLRTDYNE-----PGSVPSAVRG---LE 92

  Fly   283 SQSQTTAVHRSVA-YAGSAADDLLNTATSRNMLLHSSKLNKLLKGAGATGSGGERSGSESP-GRA 345
            ..:.:::..|.|| ::.:....:.....|    ||:.:.....:..|::....||:...|| |..
Zfish    93 DATPSSSHTREVAGFSRATVGPVYGPPVS----LHTREGRYERRLDGSSSDSRERAYDHSPYGHH 153

  Fly   346 GGATPLTTTSTITNNSFSSNSLNNTITTATPTMPTIASG-----------AAGSVGLGSGAEAGV 399
            ..:.............:...||..:..:::|...||:||           ...|..|.|.|....
Zfish   154 ERSASFDRPRHYNAEYYRDRSLFASGVSSSPAASTISSGFDAPEAHFESRIRDSFTLSSSARRDP 218

  Fly   400 CSNSGTASGDILNVAAVLAAAVDNGVPTHPIRTRHNLHGRSTTSSSRSHSRSPSSYSSSHSSSSS 464
            ..:......|                     ||.|  |.|.:.||..|.||.||...|:..:..:
Zfish   219 YRDDRGRRAD---------------------RTYH--HHRRSRSSHSSQSRHPSPQRSTGQTPKA 260

  Fly   465 SHSSSHSHASSPVQSSGNCAMAEGRSSRTVNSVTVTSNSSNPSGTAVTVSSAGVGGGCGSSSSSS 529
            :||...| |.||         :.|..||   |.:.:|:|.:.|.|:.|          ||.||.|
Zfish   261 AHSPKRS-ALSP---------SRGPPSR---SRSQSSSSDSVSSTSST----------GSGSSDS 302

  Fly   530 SSSSSSGSSCL-------------TANPVVHSEDNRPLAIRVRNLPARSSDTSLKDGLFHEYKKH 581
            :||||.||...             ||..:.:.|..|...|||:|||.||:|||||||||||:||:
Zfish   303 NSSSSEGSRARSVQSTATHAPPANTALTLDNDEPRRSFGIRVQNLPTRSTDTSLKDGLFHEFKKY 367

  Fly   582 GKVTWVKVVGQNSERYALVCFKKPDDVEKALEVSHDKHFFGCKIEVEPYQGYDVE-DNEFRPYEA 645
            ||||.|::.|.:.|||.||.|::.:|.||||.||..|.|||..|||..:.|.:.| :|||||.:.
Zfish   368 GKVTSVQIHGASEERYGLVFFRQQEDQEKALSVSKGKLFFGMLIEVTAWNGPETESENEFRPLDG 432

  Fly   646 ELDEYHPKSTRTLFIGNLEKDITAGELRSHFEAFGEIIEIDIKK-QGLNAYAFCQYSDIVSVVKA 709
            .:||:|||:|||||||||||.....:|...|:.||||::||||: .|:..|||.|||||.||.||
Zfish   433 RIDEFHPKATRTLFIGNLEKTTNYQQLLDVFQRFGEIVDIDIKRVNGVPQYAFVQYSDIASVCKA 497

  Fly   710 MRKMDGEHLGSNRIKLGFGKSMPTNCVWIDGVDEKVSESFLQSQFTRFGAVTKVSIDRNRQLALV 774
            ::|||||:||:||:||||||||||.|||:||:...::|.:|...|.|:|.|.||..||.:.:|||
Zfish   498 IKKMDGEYLGTNRLKLGFGKSMPTACVWLDGLTSNITEQYLTRHFCRYGPVVKVVFDRLKGMALV 562

  Fly   775 LYDQVQNAQAAVKDMRGTILRRKKLQVDFASRECQDAFYDKQEKQQQQSSGSNPRFSRYESSASS 839
            ||:....|||||::.:|..:...|::|||||:|.|.|||     :..|:||.:.| ..|:
Zfish   563 LYNNTDFAQAAVRETKGWKIGGNKIKVDFASQESQMAFY-----RSMQASGQDIR-DFYD----- 616

  Fly   840 LQSRSRASSFSRHQNNSNDDCSPINTPGGASSGISSASNLINQSTSINISNIGTNACSAMPAPSL 904
                                                                             
Zfish   617 ----------------------------------------------------------------- 616

  Fly   905 ASAVVSCNVNASGTVPASTSMPSGVSSSSSSLPMSPAALAQRHRMVRNARQTVDCDFNEVGRLRF 969
                          :|:..                           |:.|:|...||
Zfish   617 --------------IPSDR---------------------------RDERRTPYHDF-------- 632

  Fly   970 RSSEEVSGGAGNSTQFEDVR-----CDSPVTARQGSAVNCFTGPTAAVGESIDGTLNNNQITGGA 1029
                     ......:|:||     .|.|.....|.:...:|        .:|
Zfish   633 ---------PAERAYYENVRTPGIYADDPRREYAGRSRERYT--------ELD------------ 668

  Fly  1030 EGFTGSGGSILSRRRCGKTPKDLHPVHNQRIQLAEQVEECPSSGDEGVVSPRKRIKMDYH--HHH 1092
                                      |.|              ||.  ..||      ||  |..
Zfish   669 --------------------------HYQ--------------GDH--FDPR------YHEDHRE 685

  Fly  1093 HHSNASGVESTGEHSSINKPSPLLLSNCDVIHDPLNRKSEIRRVSETPSG--SPSIKFPGHLPSA 1155
            :.......|:..::|.|.:..              .|:.|..|. ||..|  |||.:.....|||
Zfish   686 YRDYRDPFEAITKYSYIQRER--------------ERERERERF-ETDRGRWSPSHQRRALTPSA 735

  Fly  1156 PQSLMLSCRRPSIDVGALSALSSSSAFRHGIVGASSMDQQHMMNASAAAKRRRVTTTMQQPSSSS 1220
            ..|       ||..|                               |....|||.....:.|
Zfish   736 SPS-------PSERV-------------------------------AREAERRVYRRSSERS--- 759

  Fly  1221 TTNSSSGSGLGGISSLTPAD-----------EYHHHVSRGRGHQLHSHHSHEASGGESADGSRPG 1274
                      |..|||:|..           |:.   |.|...::........||.|...|.|
Zfish   760 ----------GSCSSLSPPPAPFDKPEKSPVEFK---SEGLEREVEPSEGERVSGAEKKRGRR-- 809

  Fly  1275 TPLCDERPEVLPTEPRRLPPPRERVRERTRDVMWLPLPKFGVLFFQQQQSRSSGGGGAGNSYLQQ 1339
                .|:.|            ||: .|:|:                  |.|
Zfish   810 ----KEKAE------------REK-GEKTK------------------QRR-------------- 825

  Fly  1340 QLGGGSTGGLGCIGAASSSACSLNNSSLNASQGMGSCSGSTFLPSPSSRYWRSSSHHQNQQNNHQ 1404
                         |.|.|.:..|:.:...||..:|
Zfish   826 -------------GRAQSPSIPLSEAEKEASLDLG------------------------------ 847

  Fly  1405 QQSQQLHGSSSSNTCLMASPARPRSLSSNSSDSDVPGQNAGGSPSLDERLRNFEENYERWSGGSS 1469
              |.:|.||.      :.|..||:..:....:.         ||:
Zfish   848 --SGKLKGSD------VDSLERPKHKADKEKEP---------SPT-------------------- 875

  Fly  1470 REHISGHTPSSATPSWQLSMHMNLSTGLNSHQTSSAS----GNSNSSSGTVSSSASNSRHKFLDI 1530
             :|:               :.:....|....|:.|.|    |...:.....:.|.|:.|...:|.
Zfish   876 -DHV---------------IRLESQKGERLEQSKSESLDRDGKGKTKKNLKADSGSDGRDSLVDS 924

  Fly  1531 DELQPSDIVKSVLAKKSVFDDDFQRLNKNQWYDPSSSDFALGSSSNIVTGSSLV---ANVSRHPG 1592
            |.|:                     ..|.::.|||              |.::|   ..:...||
Zfish   925 DRLE---------------------ARKRRFGDPS--------------GKAIVVKRGRIEEEPG 954

  Fly  1593 GPCSGNTSPALPNLAATKATPIIGNCSGGLGNSTGSKSAGLLQRLSSLSPMNSPQASMSPYNSPS 1657
            ...| .|:....|:...|...|         :....|.|...:        :|...|.|.|....
Zfish   955 FGIS-QTADFATNMGFAKDPEI---------DMKAEKEAQKRE--------HSKSRSASHYGQRE 1001

  Fly  1658 PSPSVGGVTACLGQLTKPAAPGTASAGLSGGTAASSSSPAANSGPTKGLQYPFPSHPPLPNTAAP 1722
            ...|:.|  :.||.|::.|
Zfish  1002 EVDSMKG--SSLGPLSRLA---------------------------------------------- 1018

  Fly  1723 PPAVQPAPPPLPEMGKQSRLTGQSSGNNLTKSLSVPDGPQSSPARVQLQKSASVPGSTNVGAPSS 1787
                     .|||                                |.:..|.|.||      ||:
Zfish  1019 ---------ELPE--------------------------------VNILDSKSHPG------PSA 1036

  Fly  1788 LSLDSTTASVETSASISSSTSNGNSSLTSAAIHVQKPQQSTFVEEEHTKKSGTSTSQSSSSSSKK 1852
                        |...|:...:|.                  :.:|:.:....|.|.
Zfish  1037 ------------SRRFSNDEKDGK------------------LRDEYLENIDLSQSY-------- 1063

  Fly  1853 ISSTHDKLHSKHNNRSESDKKI------KKSDKNASSSDKRKNSSTSQSSKSATPRIEDDSSEAD 1911
                  :...:.|.|.....|:      .::.:.|.:.|....|...:..|  .|:...|:|
Zfish  1064 ------RKQMEQNRRLRQQLKVPDKPGKPETPQGADAEDLEHRSLVHEVGK--PPQDVTDNS--- 1117

  Fly  1912 DTADKAEKNQRHEKEKKERQEKREKDLRKQVEREEKDRKA--------QQEEREKEDRKAK---E 1965
             ...|.:|.:..:.|...::|:..:.:|::.|..|.:..:        ||.|.|..|.:.:   .
Zfish  1118 -PPTKTKKQETFDMEMIAKRERIYRTVRQKSEDPEWNNTSSPRFQHVLQQREGEYADPRTQVGVR 1181

  Fly  1966 EEKERER-EKKAQED------REKKEREERELREKEQRDKEQKEKEIREKDLREKEQRERDNR-- 2021
            :.||..| |..||.|      |.:..:....|::::.|..|.:.|:....|..:..::.|.||
Zfish  1182 DVKESLRPEDNAQSDLEIANKRMQMSKMSTSLQDEQHRRWETRLKQDLLPDFIQGSEKRRLNRKY 1246

  Fly  2022 -EKELRDKDLREKEMREKEQREKELHREKDQREREHREKEQSRRA--MDVEQEGRGGRMRELSSY 2083
             :.||. .||...|:|...:              |.||.:.|..|  ..|...|| .|...||.
Zfish  1247 LDYELW-PDLEPGEVRSDSE--------------EDRENKPSSPAPSTSVTFSGR-HRADRLSE- 1294

  Fly  2084 QKSKMDIAGEASSLTAIDCQHNKENAMD-TIAQGTPGASPSTPSDNTPKERSRKLSRNSPVRLHK 2147
                       |.||.::....:..|.| ||          ||......||::.||
Zfish  1295 -----------SKLTLLERNKFRSFADDQTI----------TPDTKALLERAKSLS--------- 1329

  Fly  2148 RRLSSQESNHSAGGGGSCGGSSHQIHHED------------YVKRIRMENSQNISVHSSNQRLND 2200
               ||:|.|.|.....|...|.......:            |:::.:|.:       .|:.::.|
Zfish  1330 ---SSREDNWSLLDYDSHFASFRSRKDTEKVEATPRPTPSWYMRKKKMRS-------ESDDKIED 1384

  Fly  2201 RRDSKEHK--------------SSSFKEDKNSSSHISRPHGCGGSSASSSKHHHRRDKHHQKGSA 2251
            |::..:.:              ||.|::|.....|:.|.|        ....|.....:.|:|.|
Zfish  1385 RKEDPKPEEQERRELFASRFLYSSIFEQDSRRLQHLERKH--------EDPEHGAGYPYAQQGPA 1441

  Fly  2252 SSIETNSSIEVVVDPISQTKHNLNTSEEELQSHQPKREKEREHFSSHANSS---SSRHKSKRDHH 2313
            ..           .|..:.....::...||...|.::.||:.|..|....|   :||:|
Zfish  1442 DG-----------QPDPEPVVLFHSRFLELTRLQQQKNKEQSHPDSKQEESINANSRNK------ 1489

  Fly  2314 HHREKKRHSVAESTNTDEEHTPQQHNPHRRISAAGSGSAGELSSAATNTSSGKLHHQHHRRSVER 2378
                                ||:|..                   ||          |.:.|.|.
Zfish  1490 --------------------TPEQEQ-------------------AT----------HQQNSTEH 1505

  Fly  2379 KSSRGSDEGHHSSSKSLRAKLMMLSSADSDDTDDASKKHSIFDIPDDCPNVSMYDKVKARSCKNM 2443
            ..       |||..||:....::.:|                  |...|.:|....|...|..::
Zfish  1506 NI-------HHSEIKSITPVQVLQTS------------------PVPAPQISPPVLVAKESLPSV 1545

  Fly  2444 QRQAEEKKIKAKFSQLKQSRAKKKRSTSYDG-DSDTEFEDRQHRNSGSSSFHGRYPGLSSSDDDD 2507
            :.:..:                   :.:|:. ||..:.|||:|
Zfish  1546 EAECVD-------------------TPAYNSLDSSVKEEDREH---------------------- 1569

  Fly  2508 DEETHQRRISSDSDAEHGGQDNQGASTLADANRVRQMQQNLRRLCDGDDSSEDEIRRNVMKHSHF 2572
                                         :...|..:|..:.:..:
Zfish  1570 -----------------------------EQPLVLPLQPLIEKPLE------------------- 1586

  Fly  2573 GKRNSNSTRIASDSESQSQ--PAPDLTIKQEHPIAPAQEIKREQLSDEEQKFKSRHDSNSSIEER 2635
                      :|.||.|..  |..|:|:|                ||..:   |.|.:|..:.|:
Zfish  1587 ----------SSSSECQDSKIPVEDITLK----------------SDVSE---SAHSTNKEVAEQ 1622

  Fly  2636 KLKTEREIKTELGDFYNSSEYTYTGKLKEYSPETRKKHKKSKRRLKSSSTADTSAAQTPLVMTPL 2700
            ...||                |.|...|   ||               |.:....|::|   :||
Zfish  1623 LSSTE----------------TPTSNAK---PE---------------SESPVKCAESP---SPL 1650

  Fly  2701 TPSIFDVHSSSECKTKFDNFDDLKTECSSIPLEISAGERRKHKERKEKKREKLRNMTE--ATVPN 2763
            :      |.|:|                            :.|:.:....|...|.||  ....|
Zfish  1651 S------HVSAE----------------------------QEKDPEPAVAEAEPNNTEDQKCADN 1681

  Fly  2764 SPTTNDTSSEKLSKEERHRLKKSKKSKSMDNSCNTKIYNSSGAHPST--SPSLPATPTSAPSTAQ 2826
            :|.     .|.:|...:.|.||:|                  |.|||  :.:||||| ...||.:
Zfish  1682 NPV-----EEAVSPPPKSRSKKTK------------------ATPSTTVTATLPATP-DKQSTRK 1722

  Fly  2827 TSKRGEDKMEFIFGIISDEEESQFPEQAETNKDIIPSSVSTTGPIVSAALQTYKQEPSTPNSKNE 2891
            :.:..::||          :.|..| :.|.:|.:                         |:||:.
Zfish  1723 SERIDKEKM----------KRSSSP-RGEASKPV-------------------------PDSKSL 1751

  Fly  2892 EAHIQLTVHEPEQQQQLERSRLSGGSSSSSHADRERHRREKREKKRREKSQREQQNQIHQKSSKV 2956
            .   :..||..|.:|         |:..:|...|.|.|..:                     |..
Zfish  1752 S---KSPVHSAEMEQ---------GTEQNSPPGRARRRNVR---------------------SVY 1783

  Fly  2957 ETKVDDDNSVDMDEAGRALEAQLMSDFDTKPISEEATPSTAATYRSDMTDVFRFSDNEDNNSVDM 3021
            .|.:|||:                    ....:::|.|...|..|....||  .||.|.......
Zfish  1784 ATPIDDDS--------------------VSQATKDAEPPRGARKRGVDRDV--GSDVEPVTRPHT 1826

  Fly  3022 TKQG--VKSEQ--QEQHKSKDKKKKKKRSKE-EKQEKLLQQQRRESLPNVASTSSAPPTPGKLTV 3081
            ||:|  .|:.|  ::....|.::.|...||| :..||..:...:.....::.......:||  .:
Zfish  1827 TKRGRPPKNRQPPEDVPAGKSERSKSTLSKELDGSEKSNEGTIKVGKGKISPLPQKGASPG--NI 1889

  Fly  3082 NVQAASKHADLQLDAKHISSPPVCKPS----PSLPCLIGDDDDDA-LHTPKAKPTTPSSRGNDGL 3141
            :|....|..| .::....||.||.:.:    .:|...:...:..| |.|.:.:|.|..|
Zfish  1890 SVSGIGKKGD-NIEKIAESSKPVTEENSLVLKNLRIRLDVTEVKAILQTSEDEPGTEDS------ 1947

  Fly  3142 TPSREKPRLISPIPKTPTIANSSTLSTQSAETPVSSGTVISSSALATTPTSSTAAGVSAAPGLDN 3206
             |.:..|.:.|        .|..||.|:.....|:.   :.|...|..|....         ::.
Zfish  1948 -PKKSSPGVSS--------KNDETLVTKLENDAVND---VDSEKQALPPEPQV---------MEP 1991

  Fly  3207 SPTSASAQCKKKESFIPGFDGQLDDRISESAVQSIS--AEFNSTSLLDNIADEPKIPVASPPRAT 3269
            ..||.|.:.:                 .|.||:.|:  .|..|.....|:   ||.|.:|   ||
Zfish  1992 HATSRSQELE-----------------LEQAVEHIAKLTEDASIQFKSNL---PKAPRSS---AT 2033

  Fly  3270 KPLDKLEESKSRVTISQEETESAVSALLGESFGTSSTTDYSLDGMDEMSSVNELETPTLVIAEPD 3334
            :|....||.|..:..:::|...|:.::      ||..|..||.....:|||        |.::||
Zfish  2034 EPEHDSEEEKPSIPSNEKELADAIDSI------TSEDTACSLPQEQILSSV--------VDSDPD 2084

  Fly  3335 EEA-ALAAKAIETAGEPASILEEPEMEPE-----REAEPDP---DPEAEIESEPVVE-VLDPEEL 3389
            .:| ...:|..|.....|.:.||....|.     |...|..   ...|..:.|||.: .:|.|:
Zfish  2085 MQALESGSKVTEACVSTAVVQEETITTPRKGCKGRAKAPKKGRGQKGAGSKKEPVKDTAIDAEK- 2148

  Fly  3390 NKAVQSLKHEDMMDIKADTPQSERDLQIDTDTEENPDEADSSGPSLKIDETVQSSSSPEKSISNN 3454
                        |.:|                         |..|:.:|..:.:..|| .||::.
Zfish  2149 ------------MSVK-------------------------SPESVPLDLPIVTERSP-VSIADA 2175

  Fly  3455 SPTPRETANIDIPNVESQPKLSNESTPQPSV-ITKLPFLDTPKTVPAGLPPSPVKIEPPTISKLQ 3518
            |.|     |.||||....|..:..:.|:.|: |:|                      .||.||.|
Zfish  2176 SLT-----NADIPNEPESPLKTETNVPKSSLAISK----------------------SPTSSKYQ 2213

  Fly  3519 -------QPLVQPVQTVLPAPHSTGSGISANSVINLDLSN-----VISSCSNTSAASATASASAS 3571
                   .|.:.|.:|.|.                 :||:     .:|.....:........|.|
Zfish  2214 SYSYKNTSPALSPTRTCLK-----------------NLSSYPSRPTVSPTDRLNQQKDAGVLSPS 2261

  Fly  3572 ISFGSPTASQNAMPQASTP----KQGPITPQQAIRTQSLIMQPPTISIPEQTPHFAVPQMVLSPQ 3632
            :|..:||.|.|.  .:.||    ..|.:.        .::.:|.|..:.|..|
Zfish  2262 LSSAAPTESPNL--HSDTPFHDASSGDLC--------KVLPKPRTAPVLEIGP------------ 2304

  Fly  3633 SHHPQQPGT-YMVGIRAPSPHSPLHSPGRGVAQSRLVGQLSPVGRPMVSQPSPQQQVQQTQQQHA 3696
                 .||. :.|.||..:..|.:.:.......:|   |.|...:|:|.||             |
Zfish  2305 -----TPGNIHAVSIRDSNVTSDMVTSKSAPQDNR---QSSVSAQPVVRQP-------------A 2348

  Fly  3697 LITSP-------QSSNISPLASPTTRVLSSSNSPTTSKVN-SYQPRNQQVPQQPSPKSVAEVQTT 3753
            .|.||       :.|.||.:||..|.|:|...:|..|:.. |.|..|..:.:|| ||.:.:
Zfish  2349 SIPSPEIKPIYSEKSVISVIASTPTSVISRVCNPLDSEEKPSSQTGNPFLEKQP-PKQIYQ---- 2408

  Fly  3754 PQLMTIPLQKMTPIQVPHHPTI---ISKVVTVQPQQATQSQVASSPPLGSLPPHKNVHLNAHQNQ 3815
            |.|        ....:.|.||:   .|:.:|            .|.||.:
Zfish  2409 PSL--------EESSICHGPTVGEDASRYIT------------ESTPLST--------------- 2438

  Fly  3816 QQPQVIAKMTAHQHQQHMQQFMHQQMIQRQQHMQQQQLHGQSQQITSAPQHQMHQQHQAQQQQQH 3880
                                                   |.|..:
Zfish  2439 ---------------------------------------GSSTGL-------------------- 2444

  Fly  3881 HNQQHLNQQLHAQQHPTQKQHQAQQQFNQQIQQHQSQQQHQVQQQNQAQQQHLSQQQHQSQQQLN 3945
                                 :.|......:..|..
Zfish  2445 ---------------------RVQTSEGVVVLSHSG----------------------------- 2459

  Fly  3946 QQHQAQQQQLQQIQKLQQMHGPQQQQKSPQGVGHLGGSTSIFASQQHNSQLPARGVPQQQHPQQL 4010
                            |:|.|||:.            |..|       ||:|
Zfish  2460 ----------------QKMEGPQRI------------SAKI-------SQIP------------- 2476

  Fly  4011 SHSSPCKPNTLVSVNQGVQPPAILTRVGSHSQPNQQQQLPHQQSSSGHPHQKQLSSPGANLPLQT 4075
                |..|..:.|                            ||..|.||.:::|.|
Zfish  2477 ----PASPMDMES----------------------------QQLVSMHPIKQELYS--------- 2500

  Fly  4076 PLNVIQNTPKIIVQQHIVAQNQVPPPQTQGNAIHYP--QNQGKDSTPPGHVEPTPAMSAQKTSES 4138
                              |.:|  ||.|:     ||  ...|....|.|::......||...|||
Zfish  2501 ------------------ASSQ--PPSTK-----YPLASEHGHSIKPQGNISTIKQESALDKSES 2540

  Fly  4139 V--SVIRTPTPTTGLAVISANTVGSLLTEENLIKISQ--PKQDELIEQDSKEVDSDYWSAKEVNI 4199
            :  ||                       :..::||.|  |...:::         .|..|:...:
Zfish  2541 LYSSV-----------------------QSGVVKILQQTPGTSQVM---------SYHPAEYPIV 2573

  Fly  4200 DSVIKKLDTPLASKDAKRAVEMQAIAPAPIPNPQPGNQSMAQETALPTTSMSVNNSNDHDTEDET 4264
            ....||.|.|       .::.|:...||.:|...|        |..|....:.:|.....|
Zfish  2574 MKHPKKGDNP-------ESLGMEGGKPAWVPTMSP--------TLSPHLPSATSNHVGFIT---- 2619

  Fly  4265 ETRQLPPAKPPIPTVGRPPGRGGSAKRGRQPRGAKKVGGFPLNSVTAAPPGVDSLVVQPGDNGVQ 4329
                                 |.|.:..|.||
Zfish  2620 ---------------------GTSKQEPRSPR--------------------------------- 2630

  Fly  4330 TRLRKPVTAPVTRGRKGRPPRNLLLQQQQLQQQQLDIQRKGMEMVTSATSSTPLPTPIPTSSVLT 4394
                          :.|.|                            .:|...:.:||.:||
Zfish  2631 --------------KSGHP----------------------------HSSFAKVSSPIGSSS--- 2650

  Fly  4395 AAEKKARNQALTQAQEQNQVASQVGTGQDIYEFHEDGGEEPKPKTISSVAPSAEDQRPRLILTIN 4459
                                                      ||.:|.|.|
Zfish  2651 ------------------------------------------PKGVSMVLP-------------- 2659

  Fly  4460 KTQPSIKNISEMEQTIQQQQQQQSEVISNTDPIGGDNSESCNTRKSRRLQEKEDRSTVDDIIEDV 4524
               |.:. :|:...|:...:|   .||
Zfish  2660 ---PGLP-LSQYVSTVHHSEQ---SVI-------------------------------------- 2679

  Fly  4525 VRNTNTPTGTGPHLPKGAQTPPRRSGRNAQAKKTDAVQIINAVGRPRRSKDRKTIGEQTANLIEE 4589
                               .||.                 ||.|         :||..:
Zfish  2680 -------------------MPPH-----------------NAHG---------SIGRMS------ 2693

  Fly  4590 VTASNATVAASHLAPPEGAGVESHVPQLDAKEVEPVSVVTPISTPAPVSVAAPVTVPVPAMVPVK 4654
                           |...|...|:||.|.:          ::|| |:|:
Zfish  2694 ---------------PHRVGPMGHIPQGDVR----------VNTP-PLSM--------------- 2717

  Fly  4655 PTMPQHPKKKAIAAAEIESYQAINSSIPSGGLPMHQTAAPATQKITGGVADAVSKALVDPVTGVI 4719
                                  :|.:|.|..|.  .:.||..|:.|...|.|
Zfish  2718 ----------------------MNYAIRSESLT--SSWAPGQQRPTSPQAVA------------- 2745

  Fly  4720 TAGMPQGKEGNLPAATAAAPANSSNEDGQAAPPPQLQHQQQQQHPQQPPQQQANLQINTTLIPSG 4784
                  .:|..|....|.|.::...|:           :.::.|........|:|:      |..
Zfish  2746 ------NREMVLKVNQATARSHDGGEE-----------EARRYHATHGRPTAAHLK------PES 2787

  Fly  4785 LPNPI-TALGKSVQLETSAAALLNKPVSVLVKGNASQVIQQQQPQIVAPAKQPIILQQNPLPTVL 4848
            :|... .||..|:||:               :.|.|                     |..:..:|
Zfish  2788 IPAEYREALHSSLQLD---------------RFNMS---------------------QRDMRVLL 2816

  Fly  4849 HHAQHTTVRPPQPLKAHVLNREKNIQQQLTPTKQAVAQPPQHAPHSGHMLLTDTAGNQQLVQPQI 4913
            ||.|  |.||...|                              |.||  |:||.
Zfish  2817 HHQQ--TDRPAAEL------------------------------HQGH--LSDTL---------- 2837

  Fly  4914 IARHLQQQQHLQVNVPPPTAHSPHSPRIPSQQQQLGPGASISPQQQQPQTVVIKQAASAAQPQIL 4978
                             |.|.:|.|           ..||:||:
Zfish  2838 -----------------PAASTPTS-----------MAASLSPR--------------------- 2853

  Fly  4979 HVVSSKASVVPQPQQQQLPPTSSTGPHLQLAKPNYSYAPTVLTPTLPAVQQQQQQHLYKQNNQQK 5043
                                     ||| |||..
Zfish  2854 -------------------------PHL-LAKAT------------------------------- 2861

  Fly  5044 GAQIQMPPHGIIMPTHPGMLLQQKLPAHLQPQQHQLNPSPPPGKPNPVLHGLQSGQIMPGSVGSP 5108
                                 .:|.|..:...:..|:|                    ||..|
Zfish  2862 ---------------------SEKEPLKISELKRPLSP--------------------PGKEG-- 2883

  Fly  5109 PPVSAAVLKTAQQQVNSVVPVAGIRTAIPNI-SPQSQPRVSPLVLPPGIS-GVPPFDASLHDLGA 5171
                                :..||||:|:: |||   ||.  :||.|.. ..|.:.|      .
Zfish  2884 --------------------MLAIRTAMPHMASPQ---RVQ--LLPAGAGPSFPEYPA------L 2917

  Fly  5172 YVSGRRTQSPPPAHQQASPITPNDSTYRGVTASRDFMLYQHHLMRGGDYDDKMGSSPPLELRRPG 5236
            |.:.|      |||.|.:..:|                              ||.|.|
Zfish  2918 YTNLR------PAHGQFADSSP------------------------------MGISQP------- 2939

  Fly  5237 SGPPRTIAVPHSLQSPQDRTAADSPQMAQVYVHNTRIPPAHFSEIASRGLYDSGALQLEPPPAHR 5301
                                                                  ||.:.|
Zfish  2940 ------------------------------------------------------ALSITP----- 2945

  Fly  5302 PTATISVVVPQQMPAVSSGSPFIGRDGSVQPGSHHHPGKAMDMQLDEMDRMSMIAAVVQQQQEHL 5366
                                    ..|..:|.|.                        |.|.|
Zfish  2946 ------------------------TQGVQEPESS------------------------QAQAE-- 2960

  Fly  5367 PPALPAGMELASQQAPPAMAPPPGDSLVTLLQRYPVMWQGLLALKTDQAAVQMHFVHGNPNVARA 5431
                 :.:||||.|  |.       ::|.||.:||::||||||||.|.||||:||:.||..:...
Zfish  2961 -----SKVELASHQ--PV-------NMVQLLTKYPIVWQGLLALKNDTAAVQLHFLCGNKALGLR 3011

  Fly  5432 SLPSLVETNTPLLRIAQRMRLEQTQLEGVAKKMQVDKEHCMLLALPCGRDHADVLQHSRNLQTGF 5496
            ||| |.|:. .:|||.||||||..||||||::|..:.:.|:|||:|||.|..|||..::.|::.|
Zfish  3012 SLP-LPESG-GILRIVQRMRLEAQQLEGVARRMTGESDFCLLLAMPCGLDQEDVLNQTQALKSAF 3074

  Fly  5497 ITYLQQKMAAGIVNIPIPGSEQAAYVVHIFPSCDFANENLERAAPDLKNRVAELA-HLLIVIATV 5560
            |.|||.|:||||:|:|.|||.|.|:|:.|||.|:|:..:|.|.||||.::::.:: ||:|||.:|
Zfish  3075 INYLQAKLAAGIINVPNPGSNQPAFVLQIFPPCEFSESHLSRLAPDLLSQISSISPHLMIVITSV 3139

  Fly  5561  5560
            Zfish  3140  3139

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spen	NP_722615.1	RRM2_SHARP	555..628	CDD:240795	46/72 (64%)
		RRM3_SHARP	654..726	CDD:240796	44/72 (61%)
		RRM4_SHARP	727..803	CDD:240797	35/75 (47%)
		RILP-like	1997..>2055	CDD:304877	12/60 (20%)
		SPOC	5404..5527	CDD:285043	69/122 (57%)
si:ch1073-335m2.2	XP_005170404.1	RRM1_SHARP	7..81	CDD:240794	10/49 (20%)
		RRM2_SHARP	341..414	CDD:240795	46/72 (64%)
		RRM3_SHARP	441..514	CDD:240796	44/72 (61%)
		RRM4_SHARP	515..591	CDD:240797	35/75 (47%)
		Ehrlichia_rpt	1520..2098	CDD:118064	175/966 (18%)
		SPOC	2984..3105	CDD:285043	69/122 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170575247
Domainoid	1	1.000	186	1.000	Domainoid score	I3292
eggNOG	1	0.900	-	-		E1_KOG0112
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	598	1.000	Inparanoid score	I927
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D367857at2759
OrthoFinder	1	1.000	-	-		FOG0006265
OrthoInspector	1	1.000	-	-		otm24849
orthoMCL	1	0.900	-	-		OOG6_106445
Panther	1	1.100	-	-	O	PTHR23189
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.850