DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spen and Rbm15b

DIOPT Version :9

Sequence 1:	NP_722615.1	Gene:	spen / 44205	FlyBaseID:	FBgn0016977	Length:	5560	Species:	Drosophila melanogaster
Sequence 2:	XP_038938548.1	Gene:	Rbm15b / 315988	RGDID:	1305937	Length:	887	Species:	Rattus norvegicus

Alignment Length:	1024	Identity:	217/1024 - (21%)
Similarity:	341/1024 - (33%)	Gaps:	335/1024 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   438 GRSTTSSS-----RSHSRSPSSYSSSH-SSSSSSHSSSHSHASSPVQSSGNCAMAEGRSSRTVNS 496
            ||.::||:     |..........::| :|..:.|.........|..|.|.....:||::...|.
  Rat    13 GRGSSSSAKRPREREREAEAGGRRAAHKASGGTKHPVPARARDKPRGSGGGGGHRDGRAAGDANH 77

  Fly   497 VTVTSNSSN-PSGTAVTVSSAGVGGGCGSSSSSS----------SSSSSSGSSCLTANPVVHSED 550
            ...:..||. |.|...|..::|..|..|:|..:|          :..:..|:   ||.|     :
  Rat    78 RASSGRSSGAPGGGGRTGKASGDPGAGGASPRASPLPPPPPPPGAEPAGPGT---TAAP-----E 134

  Fly   551 NRPLAIRVRN--LPARSSDTSLKDGLFHEYKKHGKVTWVKVVGQNSERYALVCFKKPDDVEKALE 613
            .:.|.|...:  |||.    .|:|.|||::|:.|:::..........|.|.|.|:.|.|..:|.:
  Rat   135 YKTLLISSLSPALPAE----HLEDRLFHQFKRFGEISLRLSHTPELGRVAYVNFRHPQDAREARQ 195

  Fly   614 --VSHDKHFFGCKIEVEP-----------------------------------------YQ---- 631
              ::.....:...::|||                                         ||
  Rat   196 HALARQLLLYDRPLKVEPVYLRGGGSSRRSSSSSAAASTPPPGPPTPADPLGYLPLHGGYQYKQR 260

  Fly   632 -----------------------------------------GYDVEDNEFRPY-------EAELD 648
                                                     .|.:.|:..|||       |..:.
  Rat   261 SLSPVAAPPLREPRARHAAAAFALDAAAAAAVGLSRERALDYYGLYDDRGRPYSYQAVCEEDLMP 325

  Fly   649 EYHPKSTRTLFIGNLEKDITAGELRSHFEAFGEIIEIDIKK----QGLNAYAFCQYSDIVSVVKA 709
            |...::||.||||||:..::..|||..||.:|.|.|:.||:    || .||||.::.::....:|
  Rat   326 EDDQRATRNLFIGNLDHSVSEVELRRAFEKYGIIEEVVIKRPARGQG-GAYAFLKFQNLDMAHRA 389

  Fly   710 MRKMDGEHLGSNRIKLGFGKSMPTNCVWIDGVDEKVSESFLQSQFTRFGAVTKVSIDRNRQLALV 774
            ...|.|..:|.|.||:|:||:.||..:|:.|:....|.:.|..:|.|||::..:...:....|.:
  Rat   390 KVAMSGRVIGRNPIKIGYGKANPTTRLWVGGLGPNTSLAALAREFDRFGSIRTIDHVKGDSFAYI 454

  Fly   775 LYDQVQNAQAAVKDMRGTIL--RRKKLQVDFASRECQDAFYDKQEKQQQQSSGSNPRFSRYESSA 837
            .|:.:..||||...|||..|  ..::|:||||..|        :.:..||          |:.|.
  Rat   455 QYESLDAAQAACAKMRGFPLGGPDRRLRVDFAKAE--------ETRYPQQ----------YQPSP 501

  Fly   838 SSLQSRSRASSFSRHQNNSNDDCSPINTPGGASSGISSASNLINQSTSINISNIGTNACSAMPAP 902
            ..:........::||:|...|......||..........:.|....||::.|:...|:.
  Rat   502 LPVHYELLTDGYTRHRNLDADLRVRDRTPPHLLYSDRDRTFLEGDWTSLSKSSDRRNSL------ 560

  Fly   903 SLASAVVSCNVNASGTVPASTSMPSGVSSSSSSLPMSPAALAQRHRMVRNARQTVDCDFNEVGRL 967
                                    .|.|.|..|        ....|...:..:::...:.|..:.
  Rat   561 ------------------------EGYSRSVRS--------RSGERWGADGDRSIAKPWEERRKR 593

  Fly   968 RFRSSEEVSGGAGNSTQFEDVRCDSPVTARQGSAVNCFTGPTAAVGESIDGTLNNNQITGGAEGF 1032
            |..||:.     |.:|.       ||...|..:
  Rat   594 RSLSSDR-----GRTTH-------SPYEERSRT-------------------------------- 614

  Fly  1033 TGSGGSILSRRRCGKTP----KDLHPVHNQRIQLAEQVEECPSSGDEGVVSPRKRIKMDYHHHHH 1093
              .||...|.|...:||    |:.|.        :|..:|   ||...:.:.|...:...|||||
  Rat   615 --KGGGQQSERGSDRTPERSRKENHS--------SEGTKE---SGSNSLSNSRHSAEERSHHHHH 666

  Fly  1094 HSNASGVESTGEHSSINKPSPLLLSNCDVIHDPLNRKSEIRRVSETPSGSP-SIKFPGH------ 1151
            |.                 :|      |..|....|:||  |...|....| :::.|.|
  Rat   667 HE-----------------AP------DSSHGKKTRESE--RNHRTTEAEPKTLEEPKHETKKLK 706

  Fly  1152 -LPSAPQSLML----------SCRRPSI-----DVGALSAL-----SSSSAFRHGIVGASSMDQQ 1195
             |....|:|.|          ||...|:     |.|.:|.|     |.|...:..|.....:||
  Rat   707 TLSEYAQTLQLGWNGLLVLKNSCFPTSMHILEGDQGVISGLLKDHTSGSKLTQLKIAQRLRLDQ- 770

  Fly  1196 HMMNASAAAKRRRVTTTMQQPSSS------STTNSSSGSGLGGISSLTPADEYHHHVSRGRGHQL 1254
                    .|...||..::|.|.:      :..::.||.|..|:..:.|.      :.|.....|
  Rat   771 --------PKLDEVTRRIKQGSPNGYAVLLAIQSTPSGPGAEGMPMVEPG------LQRRLLRNL 821

  Fly  1255 HSH-HSHEASG----------GESADGSRPGTPLCDERPEVLPTEPRRL 1292
            .|: ...:|:|          |..:.|.....|.||...:.|.:..|.|
  Rat   822 VSYLKQKQAAGVISLPVGGSKGRDSTGMLYAFPPCDFSQQYLQSALRTL 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spen	NP_722615.1	RRM2_SHARP	555..628	CDD:240795	18/76 (24%)
		RRM3_SHARP	654..726	CDD:240796	31/75 (41%)
		RRM4_SHARP	727..803	CDD:240797	24/77 (31%)
		RILP-like	1997..>2055	CDD:304877
		SPOC	5404..5527	CDD:285043
Rbm15b	XP_038938548.1	RRM1_RBM15B	134..215	CDD:409970	22/84 (26%)
		RRM2_RBM15B	325..409	CDD:409972	33/84 (39%)
		RRM3_RBM15B	412..487	CDD:409974	24/74 (32%)
		SF-CC1	568..>704	CDD:273721	41/225 (18%)
		SPOC	711..884	CDD:400205	38/175 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D367857at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920