DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spen and RBM15B

DIOPT Version :9

Sequence 1:	NP_722615.1	Gene:	spen / 44205	FlyBaseID:	FBgn0016977	Length:	5560	Species:	Drosophila melanogaster
Sequence 2:	NP_037418.3	Gene:	RBM15B / 29890	HGNCID:	24303	Length:	890	Species:	Homo sapiens

Alignment Length:	1022	Identity:	213/1022 - (20%)
Similarity:	336/1022 - (32%)	Gaps:	332/1022 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   418 AAAVDNGVPTHPIRTRHNLHGRSTTSSSRSHSRSPSSYSSSHSSSSSSHSSSHSHASSPVQSSGN 482
            ||...:|...||:..|           :|...|...|....|.....:..::|..:|.  :|||:
Human    37 AAHKASGGAKHPVPAR-----------ARDKPRGSGSGGGGHRDGRGTGDANHRASSG--RSSGS 88

  Fly   483 CAMAEGRSSRTVNSVTVTSNSSNPSGTAVTVSSAGVGGGC-GSSSSSSSSSSSSGSSCLTANPVV 546
            .|...||..:.......:..|...|.........|....| |||:::....:...||...|.|..
Human    89 GAGGGGRGGKASGDPGASGMSPRASPLPPPPPPPGAEPACPGSSAAAPEYKTLLISSLSPALPAE 153

  Fly   547 HSEDNRPLAIRVRNLPARSSDTSLKDGLFHEYKKHGKVTWVKVVGQNSERYALVCFKKPDDVEKA 611
            |                      |:|.|||::|:.|:::..........|.|.|.|:.|.|..:|
Human   154 H----------------------LEDRLFHQFKRFGEISLRLSHTPELGRVAYVNFRHPQDAREA 196

  Fly   612 LE--VSHDKHFFGCKIEVEP------------------------------------------YQ- 631
            .:  ::.....:...::|||                                          ||
Human   197 RQHALARQLLLYDRPLKVEPVYLRGGGGSSRRSSSSSAAASTPPPGPPAPADPLGYLPLHGGYQY 261

  Fly   632 --------------------------------------------GYDVEDNEFRPY-------EA 645
                                                        .|.:.|:..|||       |.
Human   262 KQRSLSPVAAPPLREPRARHAAAAFALDAAAAAAVGLSRERALDYYGLYDDRGRPYGYPAVCEED 326

  Fly   646 ELDEYHPKSTRTLFIGNLEKDITAGELRSHFEAFGEIIEIDIKK----QGLNAYAFCQYSDIVSV 706
            .:.|...::||.||||||:..::..|||..||.:|.|.|:.||:    || .||||.::.::...
Human   327 LMPEDDQRATRNLFIGNLDHSVSEVELRRAFEKYGIIEEVVIKRPARGQG-GAYAFLKFQNLDMA 390

  Fly   707 VKAMRKMDGEHLGSNRIKLGFGKSMPTNCVWIDGVDEKVSESFLQSQFTRFGAVTKVSIDRNRQL 771
            .:|...|.|..:|.|.||:|:||:.||..:|:.|:....|.:.|..:|.|||::..:...:....
Human   391 HRAKVAMSGRVIGRNPIKIGYGKANPTTRLWVGGLGPNTSLAALAREFDRFGSIRTIDHVKGDSF 455

  Fly   772 ALVLYDQVQNAQAAVKDMRGTIL--RRKKLQVDFASRECQDAFYDKQEKQQQQSSGSNPRFSRYE 834
            |.:.|:.:..||||...|||..|  ..::|:||||..|        :.:..||          |:
Human   456 AYIQYESLDAAQAACAKMRGFPLGGPDRRLRVDFAKAE--------ETRYPQQ----------YQ 502

  Fly   835 SSASSLQSRSRASSFSRHQNNSNDDCSPINTPGGASSGISSASNLINQSTSINISNIGTNACSAM 899
            .|...:........::||:|...|                    |:...|
Human   503 PSPLPVHYELLTDGYTRHRNLDAD--------------------LVRDRT--------------- 532

  Fly   900 PAPSLASAVVSCNVNASGTVPASTSMPSGVSSSSSSLPMSPAALAQRHRMVRNARQTVDCDFNEV 964
            |...|.|......:....|.|:.:|                    .|...:....::|
Human   533 PPHLLYSDRDRTFLEGDWTSPSKSS--------------------DRRNSLEGYSRSV------- 570

  Fly   965 GRLRFRSSEE--VSGGAGNSTQFEDVRCDSPVTARQGSAVNCFTGPTAAVGESIDGTLNNNQITG 1027
               |.||.|.  ..|..|....:|:.|....:::.:|..       |.:..|....|
Human   571 ---RSRSGERWGADGDRGLPKPWEERRKRRSLSSDRGRT-------THSPYEERSRT-------- 617

  Fly  1028 GAEGFTGSGGSILSRRRCGKTP----KDLHPVHNQRIQLAEQVEECPSSGDEGVVSPRKRIKMDY 1088
                 .|||..  |.|...:||    |:.|.        :|..:|   |....:.:.|...:...
Human   618 -----KGSGQQ--SERGSDRTPERSRKENHS--------SEGTKE---SSSNSLSNSRHGAEERG 664

  Fly  1089 HHHHHHSNASGV------ESTGEHSSIN-KPSPLLLSNCDVIHDPLNRKSEIRRVSETPSGSPSI 1146
            ||||||..|...      :|...|.:.. :|.||        .:|.:...:::.:||
Human   665 HHHHHHEAADSSHGKKARDSERNHRTTEAEPKPL--------EEPKHETKKLKNLSE-------- 713

  Fly  1147 KFPGHLPSAPQSLML----------SCRRPSI-----DVGALSAL-----SSSSAFRHGIVGASS 1191
                    ..|:|.|          ||...|:     |.|.:|:|     |.|...:..|.....
Human   714 --------YAQTLQLGWNGLLVLKNSCFPTSMHILEGDQGVISSLLKDHTSGSKLTQLKIAQRLR 770

  Fly  1192 MDQQHMMNASAAAKRRRVTTTMQQPSSS------STTNSSSGSGLGGISSLTPADE---YHHHVS 1247
            :||         .|...||..::|.|.:      :|..:.||.|..|:.::.|..:   ..:.||
Human   771 LDQ---------PKLDEVTRRIKQGSPNGYAVLLATQATPSGLGTEGMPTVEPGLQRRLLRNLVS 826

  Fly  1248 RGRGHQLHSHHSHEASGGESADGSRP--GTPLCDERPEVLPTEPRRL 1292
            ..:..|.....|....|.:..||:..  ..|.||...:.|.:..|.|
Human   827 YLKQKQAAGVISLPVGGSKGRDGTGMLYAFPPCDFSQQYLQSALRTL 873

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spen	NP_722615.1	RRM2_SHARP	555..628	CDD:240795	14/74 (19%)
		RRM3_SHARP	654..726	CDD:240796	31/75 (41%)
		RRM4_SHARP	727..803	CDD:240797	24/77 (31%)
		RILP-like	1997..>2055	CDD:304877
		SPOC	5404..5527	CDD:285043
RBM15B	NP_037418.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..133		24/108 (22%)
		RRM1_RBM15B	137..218	CDD:240998	22/102 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	219..253		0/33 (0%)
		RRM2_RBM15B	329..413	CDD:241000	33/84 (39%)
		RRM3_RBM15B	416..491	CDD:241002	24/74 (32%)
		RRM	529..>639	CDD:330708	29/176 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	547..705		43/228 (19%)
		Nuclear localization signal. /evidence=ECO:0000255	593..597		1/3 (33%)
		SPOC	712..887	CDD:311609	41/187 (22%)
		Interaction with Epstein-Barr virus BMLF1	722..890		36/161 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D367857at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820