DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spen and Rbm15

DIOPT Version :9

Sequence 1:	NP_722615.1	Gene:	spen / 44205	FlyBaseID:	FBgn0016977	Length:	5560	Species:	Drosophila melanogaster
Sequence 2:	NP_001039272.1	Gene:	Rbm15 / 229700	MGIID:	2443205	Length:	962	Species:	Mus musculus

Alignment Length:	1229	Identity:	243/1229 - (19%)
Similarity:	372/1229 - (30%)	Gaps:	523/1229 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   426 PTHPIRTRHNLHGRSTTSSSRSHSRSPSSYSSSHSSSS------SSHSSSHSHASSPVQSSGNCA 484
            |..|.|:|    |...:||....|:.......|:.|||      .|..|.|...||....|....
Mouse    52 PVKPKRSR----GGEDSSSRGERSKKLGGSGGSNGSSSGKTDSGGSRRSLHLDKSSSRGGSREYE 112

  Fly   485 MAEGRSSRTVNSVTVTSNSSNPSGTAVTVSSAGVGGGCGSSSSSSSSSSSSGSSCLTANPVVHSE 549
            ...|.||..::|.: :.::.|.||...:.||:..|||...||.::||:...|..      |.:.
Mouse   113 TGGGSSSSRLHSYS-SPSTKNSSGGGESRSSSRGGGGESRSSGAASSAPGGGDG------VEYK- 169

  Fly   550 DNRPLAIRVRNLPARSSDTSLKDGLFHEYKKHGKVTWVKV-----VGQNSERYALVCFKKPDDVE 609
                 .:::..|.::.||.:::||||||:|:.|.|: ||:     .|...||.|.|.|::|:|..
Mouse   170 -----TLKISELGSQLSDEAVEDGLFHEFKRFGDVS-VKISHLSGSGSGDERVAFVNFRRPEDAR 228

  Fly   610 ------------------KALEVSH-------DKHFF---------------------GCKIEVE 628
                              :|:.||.       ||..:                     |.:..:.
Mouse   229 AAKHARGRLVLYDRPLKIEAVYVSRRRSRSPLDKDAYAPSSSVVGTSVGSHRHAPGGGGGQRSLS 293

  Fly   629 P------YQGYDVE---------------------DNEFRPYE---------------------A 645
            |      |:.|.::                     :.::..|:                     .
Mouse   294 PGGAALGYRDYRLQQLALGRLPPPPPPPLPRELERERDYPFYDRVRPAYSLEPRVGAGAGAAPFR 358

  Fly   646 ELDEYHP----KSTRTLFIGNLEKDITAGELRSHFEAFGEIIEIDIKKQG---LNAYAFCQYSDI 703
            |:||..|    ::.||||:|||:..:|..:||..|:.||.|.|:|||:..   .:.|.|.::.::
Mouse   359 EVDEISPEDDQRANRTLFLGNLDITVTENDLRRAFDRFGVITEVDIKRPSRGQTSTYGFLKFENL 423

  Fly   704 VSVVKAMRKMDGEHLGSNRIKLGFGKSMPTNCVWIDGVDEKVSESFLQSQFTRFGAVTKVSIDRN 768
            ....:|...|.|:.:..|.||:|:||:.||..:|:.|:...|..:.|..:|.|||.:..:...:.
Mouse   424 DMSHRAKLAMSGKIIIRNPIKIGYGKATPTTRLWVGGLGPWVPLAALAREFDRFGTIRTIDYRKG 488

  Fly   769 RQLALVLYDQVQNAQAAVKDMRGTIL--RRKKLQVDFASRECQDAFYDKQEKQQQQSSGSNPRFS 831
            ...|.:.|:.:..|.||...|||..|  ..::|:||||         |.:.:.|||.....| .:
Mouse   489 DSWAYIQYESLDAAHAAWTHMRGFPLGGPDRRLRVDFA---------DTEHRYQQQYLQPLP-LT 543

  Fly   832 RYESSASSLQSRSRASSFSRHQNNSNDDCSPINTPGGASSGISSASNLINQSTSINISNIGTNAC 896
            .||....:...|:
Mouse   544 HYELVTDTFGHRA---------------------------------------------------- 556

  Fly   897 SAMPAPSLASAVVSCNVNASGTVPASTSMPSGVSSSSSSLPMSPAALAQRHRMVRNARQTVDCDF 961
               |.|                                               :|:||
Mouse   557 ---PDP-----------------------------------------------LRSAR------- 564

  Fly   962 NEVGRLRFRSSEEVSGGAGNSTQFEDVRCDS-----PVTARQGSAVNCFTGPTAAVGESIDGTLN 1021
            :....|.:|..:            .|:..||     |...|:.||....:..||.  |.:|.
Mouse   565 DRTPPLLYRDRD------------RDLYTDSDWVPPPPPVRERSARAATSAVTAY--EPLDS--- 612

  Fly  1022 NNQITGGAEGFTGSGGSILSRRRCG------KTPKDLHPVHNQRIQLAEQVEECPSSGDEGVVSP 1080
                              |.|||.|      :..:||                 |||.|:    |
Mouse   613 ------------------LDRRRDGWSLDRDRGDRDL-----------------PSSRDQ----P 638

  Fly  1081 RKRIKMDYHHHHHHSNASGVESTGEHSSINKPSPLLLSNCDVIHDPLNRKSEIRRVSETPSGSPS 1145
            |||...:             ||.|.|                    |:|..|    ||.|
Mouse   639 RKRRLPE-------------ESGGRH--------------------LDRSPE----SERP----- 661

  Fly  1146 IKFPGHLPSAPQSLMLSCRRPSIDVGALSALSSSSAFRHGIVGASSMDQQH---MMNASAAAKRR 1207
             :...|...:|.      |.|.:         ||:..|:.    |..|:..   ::..|:..:.|
Mouse   662 -RKQRHCTPSPD------RSPEL---------SSNRDRYN----SDNDRSSRLLLLERSSPVRDR 706

  Fly  1208 RVTTTMQQPSSSSTTNSSSGSGLGGISSLTPADEYHHHVSRGRGHQLHSHHSHEASGGESADGSR 1272
            |.:....|.......||:|                   ..|.|.|:
Mouse   707 RGSLEKSQSDKRDRKNSAS-------------------AERDRKHR------------------- 733

  Fly  1273 PGTPLCDERPEVLPTEPRRLPPPRERVRERTRDVMWLPLPKFGVLFFQQQQSRSSGG--GGAGNS 1335
                      ...|||.:.                  ||.|         :.||.|.  ..:.:|
Mouse   734 ----------TAAPTEGKN------------------PLKK---------EDRSDGNAPSASTSS 761

  Fly  1336 YLQQQLGGGSTGGLGCIGAASSSACSLNNSSLNASQGMGSCSGSTFLPSPSSRYWRSSSHHQNQQ 1400
            ..|:.......||...:.|:|...|.       |.|||.....|.|          .|:.|..|.
Mouse   762 SKQKPPSQKQDGGTAPVAASSPKLCL-------AWQGMLLLKNSNF----------PSNMHLLQG 809

  Fly  1401 NNHQQQSQQLHGSSSSNTCLMASPARPRSLSSNSSDSDVPGQNAGGSPSLDERLRNFEENYERWS 1465
            :.....|..:.||:......:....|.|.                ..|.|||..|..:      .
Mouse   810 DLQVASSLLVEGSTGGKVAQLKITQRLRL----------------DQPKLDEVTRRIK------V 852

  Fly  1466 GGSSREHISGHTPSSATPSWQLSMHMNLSTGLNSHQTSSASGNSNSSSGTVSSSASNSR 1524
            .|.     :|:....|.|                   .|:...|:|||.|..::||..|
Mouse   853 AGP-----NGYAILLAVP-------------------GSSDSRSSSSSATSDTAASTQR 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spen	NP_722615.1	RRM2_SHARP	555..628	CDD:240795	28/123 (23%)
		RRM3_SHARP	654..726	CDD:240796	26/74 (35%)
		RRM4_SHARP	727..803	CDD:240797	23/77 (30%)
		RILP-like	1997..>2055	CDD:304877
		SPOC	5404..5527	CDD:285043
Rbm15	NP_001039272.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..167		35/125 (28%)
		RRM1_RBM15	168..250	CDD:240997	23/88 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	257..297		4/39 (10%)
		RRM2_RBM15	366..452	CDD:240999	29/85 (34%)
		RRM3_RBM15	455..527	CDD:241001	22/80 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	553..779		76/527 (14%)
		RRM	623..>751	CDD:330708	46/285 (16%)
		SPOC	781..955	CDD:311609	34/170 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	866..885		7/18 (39%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0112
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.770