DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment spen and grld-1

DIOPT Version :9

Sequence 1:	NP_722615.1	Gene:	spen / 44205	FlyBaseID:	FBgn0016977	Length:	5560	Species:	Drosophila melanogaster
Sequence 2:	NP_741283.1	Gene:	grld-1 / 176827	WormBaseID:	WBGene00017929	Length:	520	Species:	Caenorhabditis elegans

Alignment Length:	361	Identity:	86/361 - (23%)
Similarity:	144/361 - (39%)	Gaps:	74/361 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   554 LAIRVRNLPARSSDTSLKDGLFHEYKKHGKVTWVKVV--GQNSERYALVCFKKPDDVEKALEVSH 616
            |.:|:.....|.....:|..|..|.||:.... :|||  .:..||.|.|.|::.|...|......
Worm    34 LNLRISGFDDRLEREQIKQYLTQELKKYAPFE-IKVVKNPEEDERLAYVNFERNDCARKVRYTLM 97

  Fly   617 D--KHFFGCKIEVEP------YQGYDVED--------------------NEFRPYEA----ELDE 649
            |  |...|.:::.:|      .:|..:.|                    |..||.:.    .|.:
Worm    98 DRLKSVLGKRVQCDPAGILRDQEGKYIPDRFNRAQHGADSKREGGSGSGNRGRPTKEPSTWRLKQ 162

  Fly   650 YHPKSTRTLFIGNLEKDITAGELRSHFEAFGEIIEIDIKKQGLN---AYAFCQYSDIVSVVKAMR 711
            ...::|||||:||:..|:...|:|..||..|::.|:|||.. :|   ||||..:..:...::|..
Worm   163 DDDEATRTLFVGNMPSDVKEREIRHVFEEHGKVEEVDIKTP-INTDAAYAFVMFQTVDQAIQAKA 226

  Fly   712 KMDGEHL--GSNRIKLGFGKSMPTNCVWIDGVDEKVSESFLQSQFTRFGAVTKVSIDRNRQLALV 774
            :.....:  |.:|:|:|:|||..:..:::.|:.....:..||..|..||.|..:..|..:..|.|
Worm   227 EEQDRPIRAGGSRMKIGYGKSQVSRRLFVGGLGSWCDKEILQKAFGEFGFVENIDYDHGQPYAYV 291

  Fly   775 LYDQVQNAQAAVKDMRGTILRRKKLQVDFASRECQDAFYDKQEKQQQQSSGSNPRFSRYESSASS 839
            :|:....:|.|.:.:||..:                            |.|::|....|   |..
Worm   292 VYENTHTSQEACRSLRGACI----------------------------SKGNHPIMVDY---AKD 325

  Fly   840 LQSRSRASSFSRHQNNSND--DCSPINTPGGASSGI 873
            |.::.....|.|.:..|..  ..|.:.||.|:...:
Worm   326 LTAQPEKQQFMRKRRASKSPVGASAVRTPPGSPKDV 361

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spen	NP_722615.1	RRM2_SHARP	555..628	CDD:240795	20/76 (26%)
		RRM3_SHARP	654..726	CDD:240796	26/76 (34%)
		RRM4_SHARP	727..803	CDD:240797	18/75 (24%)
		RILP-like	1997..>2055	CDD:304877
		SPOC	5404..5527	CDD:285043
grld-1	NP_741283.1	RRM_SF	33..>93	CDD:302621	18/59 (31%)
		RRM_SF	167..246	CDD:302621	27/79 (34%)
		RRM3_Spen	253..324	CDD:240756	19/101 (19%)
		SPOC	376..482	CDD:285043
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D367857at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920