Protein Alignment spen and cec-8

DIOPT Version :9

• Sequence 1: NP_722615.1
• Gene: spen / 44205
• FlyBaseID: FBgn0016977
• Length: 5560
• Species: Drosophila melanogaster
• Sequence 2: NP_497198.1
• Gene: cec-8 / 175202
• WormBaseID: WBGene00021913
• Length: 679
• Species: Caenorhabditis elegans
• Alignment Length: 727
• Identity: 147/727 - (20%)
• Similarity: 264/727 - (36%)
• Gaps: 249/727 - (34%)

  Fly  1821 VQKP-----QQSTFVEEEHTKKSGTSTSQSSSSSSKKISSTHDKLHSKHNNRSESDKKIKKSDKN 1880
            :.||     .|.|..:.|.::.....:.:..||..::.:|..|.     ::.|:||...||..||
 Worm   178 MNKPPKKSKHQDTSDDSEESEDEEEKSPRKRSSKKRRAASVSDS-----DSDSDSDFDKKKWKKN 237

  Fly  1881 ASSSDKRKNSSTSQSSKSATPRIEDDSSEADDTADKAEKNQRHEKEKKERQEKREKDLRKQVERE 1945
            .:...||.:||             ||.||.:....|::|:::.:|.||..:.||..:   ....:
 Worm   238 KAKRSKRDDSS-------------DDDSEMERRRKKSKKSKKSKKFKKSEKRKRAVN---DSSSD 286

  Fly  1946 EKDRKAQQEEREKEDRKAK-EEEKEREREKKAQEDREKKEREERELREKEQRDKEQKEKEIREKD 2009
            ::|.:.:.|:|.|:.:||. :...|.|.|:|:.:.|.||.::|.: .|::..|.|::..|:: |:
 Worm   287 DEDEEEKPEKRSKKSKKAVIDSSSEDEEEEKSSKKRSKKSKKESD-EEQQASDSEEEVVEVK-KN 349

  Fly  2010 LREKEQRERDNREKELRDKDLREKEMREKEQREKELHREKDQREREHREKEQSRRAMDVEQEGRG 2074
            .:..::..:....||       |.|....::.|:.:.::|..:..:.:.||.|   .|.|:|...
 Worm   350 SKSPKKTPKKTAVKE-------ESEESSGDEEEEVVKKKKSSKINKRKAKESS---SDEEEEVEE 404

  Fly  2075 GRMRELSSYQK-SKMDIAGEASSLTAIDCQHNKENAMDTIAQGTPGASPSTPSDNTPKERSRKLS 2138
            ...::..|.:| ||...|.|.|...:.|.:..:|                  .|.:||::.:
 Worm   405 SPKKKTKSPRKSSKKSAAKEESEEESSDNEEEEE------------------VDYSPKKKVK--- 448

  Fly  2139 RNSPVRLHKRRLSSQESNHSAGGGGSCGGSSHQIHHEDYVKRIRMENSQNISVHSSNQRLNDRRD 2203
              ||.:..|:..:..||.                           |.|.|            ..:
 Worm   449 --SPKKSSKKPAAKVESE---------------------------EPSDN------------EEE 472

  Fly  2204 SKEHKSSSFKEDKNSSSHISRPHGCGGSSASSSKHHHRRDKHHQKGSASSIETNSSIEVVVDPIS 2268
            .:|.:.|..|:||.                         .:.:.:.||:.:|:
 Worm   473 EEEVEESPIKKDKT-------------------------PRKYSRKSAAKVES------------ 500

  Fly  2269 QTKHNLNTSEEELQSHQPKREKEREHFSSHANSSSSRHKSKRDHHHHREKKRHSVAESTNTDEEH 2333
             |:.:.|..|||:: ..||::.:....||                    ||..:|.||.|.:|:
 Worm   501 -TESSGNEEEEEVE-ESPKKKGKTPRKSS--------------------KKSAAVEESDNEEED- 542

  Fly  2334 TPQQHNPHRRISAAGSGSAGELSSAATNTSSGKLHHQHHRRSVERKSSRGSDEGHHSSSKSLRAK 2398
              .:.:|.:|.|...|..                     :|:.:.:|...||.
 Worm   543 --VEESPKKRTSPRKSSK---------------------KRAAKEESEESSDN------------ 572

  Fly  2399 LMMLSSADSDDTDDASKKHSIFDIPDDCPNVSMYDK----------VKARSCKNMQRQAEE---- 2449
                   :.::.:|:.||:               ||          .|..|.::...:.||
 Worm   573 -------EVEEVEDSPKKN---------------DKTLRKSPRKPAAKVESEESFGNEEEEEVEE 615

  Fly  2450 ---KKIKAKFSQLKQSRAKKKRSTSYDGDSDTEFEDRQHRNSGSSSFHGRYPGLSSSDDDDDEET 2511
               ||.|......|:|.||::...|    ||.|.|::....:||   |...|..|.:|:.|:.
 Worm   616 SPKKKGKTPRKSSKKSAAKEESEES----SDDEEEEQAEETNGS---HTESPTKSKTDESDNS-- 671

  Fly  2512 HQRRISSDSDAE 2523
                .|||.|.|
 Worm   672 ----TSSDEDDE 679

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spen	NP_722615.1	RRM2_SHARP	555..628	CDD:240795
		RRM3_SHARP	654..726	CDD:240796
		RRM4_SHARP	727..803	CDD:240797
		RILP-like	1997..>2055	CDD:304877	10/57 (18%)
		SPOC	5404..5527	CDD:285043
cec-8	NP_497198.1	CD_CEC-4_like	114..167	CDD:349317

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S7255
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950