DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment spen and din-1

DIOPT Version :9

Sequence 1:NP_722615.1 Gene:spen / 44205 FlyBaseID:FBgn0016977 Length:5560 Species:Drosophila melanogaster
Sequence 2:NP_496485.2 Gene:din-1 / 174782 WormBaseID:WBGene00008549 Length:2407 Species:Caenorhabditis elegans


Alignment Length:2988 Identity:566/2988 - (18%)
Similarity:969/2988 - (32%) Gaps:1139/2988 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   453 SSYSSSHSSSSSSHSSSHSHASSPVQSSGNCAMAEGRSSRTVNSVTVTSNSSNPSGTAVTVSSAG 517
            ||.:|..|:.||..|||..:|....|..|:...||.:|....|.:                 .|.
 Worm    92 SSMASMSSTPSSGQSSSPRNAELSPQRYGDTRGAEVKSPSFRNQM-----------------EAR 139

  Fly   518 VGGGCGSSSSSSSSS---------SSSGSSCLTANPVVHSEDNRPLAIRVRNLPARSSDTSLKDG 573
            .||...|..|....|         .|..::|     ||:.              .:|..|..:| 
 Worm   140 RGGPHLSVQSQQRHSREYWPIPEFPSESTAC-----VVYE--------------IQSGSTPERD- 184

  Fly   574 LFHEYKKHGKVTWVKVVGQNSERYALVCFKKPDDV--EKALEVSHDK---HFF-----GCKIEVE 628
            ||...|||.|.:.|                 |.|:  |...|....|   |::     |.|.:..
 Worm   185 LFELVKKHSKRSGV-----------------PIDIQLESTTEPGWKKARVHYYRLDTDGLKADKS 232

  Fly   629 PYQGYDVEDNEFRPY-----EAELDEYHP---------------KSTRTLFIGNLEKDITAGELR 673
            ...|   ...:||.|     |.:..:.||               |::.::.:.:|::. :....|
 Worm   233 LILG---RPPKFRVYYPTSGEQKHPQCHPSTSYAIPKLKGDHLLKASCSVHVPHLDRH-SPDHYR 293

  Fly   674 SHFEAFGEIIEIDIKKQGLN-AYAFCQYSDIVSVVKAM------RKMDGEHLGSNRIKLGFGKSM 731
            ..||::|::|::|:.|...| |:|..|:::|....||:      :.|..:...|:||.:.:   :
 Worm   294 RRFESYGQVIDVDMVKSNDNKAFAVVQFTNIDDAQKALQDTNIPKPMSYQSRPSHRIIIFY---L 355

  Fly   732 PTNCVWIDGVDEKVSESFLQSQFTRFGAVTKVSIDRNRQLALVLYDQVQNAQAAVKDMRGTILRR 796
            |..|     .:|::. ..::|...|   :..:.:|...:.|::..|.::.|...:|.|:  ::.|
 Worm   356 PIEC-----TNEEIM-LIIRSLSDR---IVDICVDWWDRSAVITLDDMEPANLLLKRMK--LVGR 409

  Fly   797 K-----KLQVDFASRECQDAF-----YDKQEKQQQQSSGSNPRFSRYESSASSLQSRSRASSFSR 851
            .     |:.|||    |.|.|     ..|:|..:..:..|:|      :|.|.....|.:.|.||
 Worm   410 NNFGEHKVAVDF----CSDRFNLYFINRKKENIEVAARSSSP------TSKSENDQGSSSPSSSR 464

  Fly   852 HQNNSNDDCSPINTPGGASSGISSASNLINQSTSINISNIGTNACSAMPAPSLASAVVSCNVNAS 916
            .:.|.:|   |:.|.       ||..:..||....|                          |||
 Worm   465 DRQNLHD---PLQTR-------SSVEHHTNQEDQEN--------------------------NAS 493

  Fly   917 GTVPASTSMPSGVSSSSSSLPMSPAALAQRHRMVRNARQTVDCDFNEVGRLRFRSSEEVSGGAGN 981
            |             |.|||                      |.|           |||   |:.:
 Worm   494 G-------------SDSSS----------------------DSD-----------SEE---GSSS 509

  Fly   982 STQFEDVRCDSPVTARQGSAVNCFTGPTAAVGESIDGTLNNNQITGGAEGFTGSGGSILSRRRCG 1046
            |.:..|.:.|                    |.|..|..:.:.:                 :|...
 Worm   510 SNEDSDEQND--------------------VDEEDDEDVVSEE-----------------KRHEP 537

  Fly  1047 KTPKDLHPVHNQRIQLAEQVEECPSSGDEGVVSPRKRIKMDYHHHHHHSNASGVESTGEHSSINK 1111
            :..|...|.:..|.:         |:||:......:|........||.::.| .|...|......
 Worm   538 EEGKSSSPGNGHRDE---------SNGDKDHEDSSERFSQPSTSSHHETSHS-PEKDSEAYQSRS 592

  Fly  1112 PSPLLLSNCDVIHDPLNRKSEIRRVSETPSGSPS--IKFPGHLPSAPQSLMLSCR--RPSIDVGA 1172
            .|||...:....::.|..|...:..|.|.|.:.|  ::....:|..|.:.||...  ||.|||  
 Worm   593 FSPLNYQSQSPGYEFLESKEIKQEFSPTTSSASSSDLELDMEMPDNPLTRMLERMHWRPFIDV-- 655

  Fly  1173 LSALSSSSAFRHGIVGASSMDQQHMMNASAAAKRRRVTTTMQQPSSSSTTNSSSGSGLGGISSLT 1237
                   |:|      .:.:|:...:|..|.|...:.|                           
 Worm   656 -------SSF------VNRIDEIVELNQKARASYEKFT--------------------------- 680

  Fly  1238 PADEYHHHVSRGRGHQLHSHHSHEASGGESADGSRPGTPLCDERPEVLPTEPRRLPPPRE----- 1297
                                             .|| .|.|: ..|||..:......||:     
 Worm   681 ---------------------------------GRP-FPKCN-NDEVLSIQKIVFHEPRDYYYYE 710

  Fly  1298 ----RVRERTRDVMWLPLPKFGVL-FFQQQQSRSSGGGGAGNSYLQQQLGGGSTGGLGCIGAASS 1357
                .:..|.||  |..|.....| .|:...|:..|         :.|..||.|.|         
 Worm   711 NPCSELEVRIRD--WRKLSDTADLDDFRATDSKELG---------RDQPAGGRTSG--------- 755

  Fly  1358 SACSLNNSSLNASQGMGSCSGSTFLPSPSSRYWRSSSHHQNQQNNHQQQSQQLHGSSSSNTCLMA 1422
                  ..||:.|:              ::|....|:||.      .:.:|:.|.       |..
 Worm   756 ------RPSLDESR--------------TNRLSFDSTHHP------AELAQRSHS-------LCI 787

  Fly  1423 SPARPRSLSSNS-----SDSDVPGQNAGGSPSLDERLRNFEENYERWSGGSSREHISGHTPSSAT 1482
            .|..|.:....|     :.:.:||.:   .||.              |||.:       ||.|:.
 Worm   788 GPMTPSTPFPTSQPLLVNTTHLPGTS---QPST--------------SGGIT-------TPRSSQ 828

  Fly  1483 PSWQLSMHMNLSTGLNSHQTSSASGNSNSSSGTVSSSASNSRHKFLDIDELQPSDIVKSVLAKKS 1547
            |.       .|.:.::.|       ||.||:|                   :|:.|  ..|..:|
 Worm   829 PP-------PLMSPVSRH-------NSMSSTG-------------------RPASI--QTLRHQS 858

  Fly  1548 VFDDDFQRLNKNQWYDPSSSDFALGSSSNIVTGSSLVANVSRHPGGPCSGNTSPALP----NLAA 1608
            |.            :.|                     :||..|         |.:|    .:.|
 Worm   859 VM------------FPP---------------------DVSIPP---------PPIPPTHDEMMA 881

  Fly  1609 TKATPIIGNCSGGLGNSTGSKSAGLLQRLSSLSPMNSPQASMSPYNSPSPSPSVGGVTACLGQLT 1673
            .:.||.....|                  .::.|:.||     |:.:|..:           .||
 Worm   882 PRGTPPSRRSS------------------ETMVPLRSP-----PFGTPIQN-----------LLT 912

  Fly  1674 KPAAPGT-ASAGLSGGTAASSSSPAANSGPTKGLQ-YPFPSHPPLPNTAAPPPAVQPAPPPLPEM 1736
            .|..|.. ..|..|.||.:.|||  |:|.|...:. .|....|....|:.||.            
 Worm   913 MPIVPPPHLIAATSTGTHSVSSS--AHSTPRHSISGTPVHCEPSNSKTSQPPT------------ 963

  Fly  1737 GKQSRLTGQSSGNNLTKSLSVPDGPQSSPARVQLQKSASVPGSTNVGAPSSLSLDSTTASVETSA 1801
                                    |:|.|.:||::.             .::|....:.::....
 Worm   964 ------------------------PKSRPEKVQIRH-------------DTISKSGPSNAINALQ 991

  Fly  1802 SISSSTSNGNSSLTSAAIHVQKPQQSTFVEEEHTKKSGTSTSQSSSSSSKKISSTHDKLHSKHNN 1866
            :.|.|.::|:                       .|||..||.....:.|..::..      ..|.
 Worm   992 ARSQSMTSGD-----------------------PKKSAPSTPVVRDAGSDLVAQI------MSNQ 1027

  Fly  1867 RSESDKKIKKSDKNASSSDKRKNSSTSQSSKSATPRIEDDSSEADDTADKAEKNQRHEKEKKERQ 1931
            .:...:|:.:.:|.:|:....:|.....|:.::||.....|:              |:...|:::
 Worm  1028 PNLGLRKLPRIEKKSSALQNIQNHQPPHSNANSTPSTPSTST--------------HQAMFKDKE 1078

  Fly  1932 EKREKDLRKQVEREEKDRKAQQEEREKEDRKAKEEEKEREREKKAQEDREKKEREERELREKEQR 1996
            ::|:|   |:.|:||::|:|::|.:.||.::.:.:.||.||.|:.:::|::::||:::.|::.::
 Worm  1079 KERKK---KEKEKEEREREARREMKRKETKEERNKRKEMERAKRLEDERQERKREKKKERDERKK 1140

  Fly  1997 DKEQKEKEIREKDLREKEQRERDNREK-------ELRDKDLREKEMREKEQREKE---------- 2044
            :||:..|:..::.|::|:.|:.|:.::       || |.|:| |..:|..|.||:          
 Worm  1141 EKEKVRKKAEKEKLKKKKHRKGDSSDESDSDSNDEL-DLDVR-KSTKEMTQEEKDHQLALLLSKG 1203

  Fly  2045 -------LHREKDQREREH----REKEQSRRAMDVEQEGRGGRMRELSSYQKSKMDIAGEASSLT 2098
                   ..|..|:|..:.    ::|.|.||.:....:..||:..:           .|.:|   
 Worm  1204 GIIENLKSRRRSDKRAHDSFEKMQQKSQQRRVLIESSDDEGGKDGD-----------KGNSS--- 1254

  Fly  2099 AIDCQHNKENAMDTIAQGTPGASPSTPSDNTP------KERSR-KLS-------RNSPVRLHKRR 2149
                  |.|.:....|...|..:|.:.|::..      |||.: :|:       .|....:|::|
 Worm  1255 ------NGEESDSEKADLPPPPAPPSLSESADQRLKVLKEREKGELTTSSDDEDHNDAGEIHQQR 1313

  Fly  2150 LSSQESNHSAGGGGSCGGSSHQIHHEDYVKRIRMENSQNISV-HSSNQRLNDRRDSK---EHKSS 2210
            |:....|.......:...|..|...::..||:|.::|::.:. |......:|::..|   ||:.|
 Worm  1314 LTEDRENRKRQKSLTAYSSDEQGERKNVPKRMRRDDSEDAAAKHPGWSAKDDQKQRKRKLEHRRS 1378

  Fly  2211 SFKEDKNSSSHISR--PHGCGGSSASSSKHHHRRDKHHQKGSASSIETNSSIEVVVDPISQTKHN 2273
            |..|.|.::....|  ||    ...|.       ::..:.||.|..::.||          |..|
 Worm  1379 SEDESKKNAKRDFRDIPH----EDVSD-------EEETEDGSRSRRQSTSS----------TISN 1422

  Fly  2274 LNTSEEELQSHQ----------------PKREKEREHFSSHANSSSSRHKSKRDHHHHREKKRHS 2322
            :...|.:.:|.:                ||....: |.|...::||::..|..||          
 Worm  1423 VTAKERKEKSGKTPLRIVPEPTGTPLLSPKILSPK-HLSPKTSTSSTKRSSISDH---------- 1476

  Fly  2323 VAESTNTDEEHTPQQHNPHRRISAAGSGSAGELSSAATNTSSGKLHHQHHRRSVERKSSRGSDEG 2387
                   :...:|:|.|             ...||.:|.|:|.|    |...|:..|        
 Worm  1477 -------ENLISPRQRN-------------RTTSSTSTATTSSK----HEALSIPEK-------- 1509

  Fly  2388 HHSSSKSLRAKLMMLSSADSDDTDDASKKHSIFDIPDDCPNVSMYDKVKARSCKNMQRQAEEKKI 2452
              ..|..:.|| ..:||.|.....|....:|..|.|.......|.                  ..
 Worm  1510 --PLSPPVTAK-SSVSSIDDPSIRDEFSMNSAADSPMSTTGRPMV------------------LT 1553

  Fly  2453 KAKFSQLKQSRAKKKRSTSYDGDSDTEFEDRQHRNSGSSSFHGRYPGLSSSDDDDDEETHQRR-- 2515
            ||.......:..|||.|:|...||          :|||||......|.:||||..|:|..::.  
 Worm  1554 KAAMKAFNSTPPKKKNSSSGQHDS----------SSGSSSDSSSSDGSTSSDDSSDDEVPKQTEP 1608

  Fly  2516 ------ISSDSDAEHGGQDNQGASTLADANRVRQMQQNLRRLCDGDDSSEDEIRRNVMKHSHFGK 2574
                  ::||    :|..:|....|   .:.|.|..:........:.|||               
 Worm  1609 VTSIPVVASD----NGSPENVVVET---PSIVSQTPREPEPFTISEQSSE--------------- 1651

  Fly  2575 RNSNSTRIASDSESQSQP-APDLTIKQEHPIAPAQEIKR--EQLSDEEQKFKSRHDSNSSIEERK 2636
                       ||.::.| .|:.:::      |..|..:  |.:|:|.:......||..::|.::
 Worm  1652 -----------SEPEAVPECPEASVE------PQMETSQNVEPVSEEHEDSHEHGDSEVAVESQQ 1699

  Fly  2637 LKTE-REIKTEL-----------------GDFYNSSEYTYTGKLKEYSPETRKKHKKSKRRLKSS 2683
            ...| :|.|.||                 || .:|.|.:......|..|.|:.: :||...|.|.
 Worm  1700 QPLEHQEEKEELENKILDVAAEHHEEQVQGD-EDSVESSIPAPSDEPDPVTQAQ-EKSAHTLISD 1762

  Fly  2684 STADTSAAQTPLVMTPLTPSIFDVHSSSECKTKFDNFDDLKTECSSIPLEISAGERRKHKERKEK 2748
            ...| .|.|          ||||...:.|    |..:.|...                       
 Worm  1763 QETD-QAVQ----------SIFDEEEADE----FPQYPDFGI----------------------- 1789

  Fly  2749 KREKLRNMTEATVPNSPTTNDTSSEKLSKEERHRLKKSKKSKSMDNSCNTKIYNSSGAHPSTSPS 2813
                                .|:.:::|.::.|.:   |.::.::|.....::         |||
 Worm  1790 --------------------STNEKEVSGKDPHNI---KPTEPLNNGHTDLLF---------SPS 1822

  Fly  2814 LPATPTSAPSTAQTSKRGEDKMEFIFGIISDEEESQFPEQAETNKDIIPSSVSTTGPIVSAALQT 2878
                 :||.::.:.|.:.||.||       ::.|....|:....:.:|...|..           
 Worm  1823 -----SSAHASEKQSTKSEDDME-------EDSELVVMEKEVPMEQVIAQEVHV----------- 1864

  Fly  2879 YKQEPSTPNSKNEEAHIQLTVHEPEQQQQLERS--------RLSGGSSSSSHADRERHRREKREK 2935
                ||.|:...||..::.:....|:..::|.|        .:|...|..:......|..|..:.
 Worm  1865 ----PSEPSPMEEEVKLETSPVPKEEPIKMEESPEQTPTPDLISNNESQDTPGAVNNHLHENHDA 1925

  Fly  2936 KRRE-KSQREQQNQIHQKSSKVETKVDDDNSVDMDEAGRALEAQLMSDFDTKPISEEATPSTAAT 2999
            .:.. :.|...|:|:.|.|.:...      :.|..:.|..|            :|:::.||..::
 Worm  1926 VQTPIQLQPASQHQVAQPSPRPAV------APDSQQNGPVL------------VSQQSQPSPMSS 1972

  Fly  3000 YRSDMTDVFRFSDNEDN----------------------------------NSVDMT-------- 3022
            .:|||......|..:.|                                  |..:||        
 Worm  1973 QQSDMAQNLILSSKDINDLAAKLHKNPEALAQATRGDCSGIFQHLLLHAQGNGQNMTPEMLQLKA 2037

  Fly  3023 -----------KQGVKSEQQEQHKSKDKKKKKKRSK-----------EEKQEKLLQQQRRESLPN 3065
                       .|.::::.::|..:||:.|:::|.|           |:::||..:::.|:.|  
 Worm  2038 AFFAQQQENEANQMMQAKMKQQTINKDRIKEQERVKRMYEENERKVEEDRREKQRKEEERQRL-- 2100

  Fly  3066 VASTSSAPPTPGKLTVNVQAASKHADLQLDA-----KHISSPPVCKPS--------PSLPCLIGD 3117
            .|:|::|       |:..|.|::....:.:.     :|:.|  :..|.        |.|...|..
 Worm  2101 AAATAAA-------TMATQKAAEALKQKQEVPRHGFQHVLS--MMTPEARSLYEQFPGLSSYINR 2156

  Fly  3118 DD----DDALHTPKAKPTTPSSRGNDGLTPSREKPRLISPIPKTP----TIANSSTLSTQSAE 3172
            |.    :..||.|......|||..:....|           ||.|    ...|.:|:.....|
 Worm  2157 DSIGATNGVLHLPTQSIQRPSSTASTSSNP-----------PKAPLQPSASVNQNTIDPAEIE 2208

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
spenNP_722615.1 RRM2_SHARP 555..628 CDD:240795 18/82 (22%)
RRM3_SHARP 654..726 CDD:240796 19/78 (24%)
RRM4_SHARP 727..803 CDD:240797 14/80 (18%)
RILP-like 1997..>2055 CDD:304877 20/81 (25%)
SPOC 5404..5527 CDD:285043
din-1NP_496485.2 RRM_SF 15..75 CDD:302621
RRM_SF 279..>332 CDD:302621 15/53 (28%)
Med21 1917..>1995 CDD:288119 18/95 (19%)
GBP_C <2041..2143 CDD:303769 21/112 (19%)
coiled coil 2098..2124 CDD:293879 7/34 (21%)
coiled coil 2133..2143 CDD:293879 2/11 (18%)
SPOC 2224..2338 CDD:285043
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 67 1.000 Domainoid score I6457
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 215 1.000 Inparanoid score I2337
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D367857at2759
OrthoFinder 1 1.000 - - FOG0006265
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 1 0.900 - - OOG6_106445
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4765
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
76.990

Return to query results.
Submit another query.