DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spen and rbm15

DIOPT Version :9

Sequence 1:	NP_722615.1	Gene:	spen / 44205	FlyBaseID:	FBgn0016977	Length:	5560	Species:	Drosophila melanogaster
Sequence 2:	XP_002933033.1	Gene:	rbm15 / 100490588	XenbaseID:	XB-GENE-999888	Length:	836	Species:	Xenopus tropicalis

Alignment Length:	806	Identity:	172/806 - (21%)
Similarity:	273/806 - (33%)	Gaps:	280/806 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   446 RSHSRSPSSYSSSHSSSSSSHSSSHSHASSPVQSSGNCA----MAEGRSSRTVNSVTVTSNSSNP 506
            :...|||:....|..:..|:...|....||...|:|:..    .:.||.|..|.....:|...:.
Frog     2 KGKERSPAKAKRSRGAEESTRERSGKKLSSGGGSNGSSGKTSESSTGRRSLHVEKAISSSRDYDQ 66

  Fly   507 SGTAVTVSSAG-VGGGCGSSSSSSSSSSSSGSSCLTANPVVHSEDNRPLAIRVRNLPARSSDTSL 570
            |..|..:...| .|...|||||...:.|..|....|.:   .:|.....::|:..|.:..||.::
Frog    67 SSRAQGLHRYGSPGASSGSSSSKGGAESRGGGGRATES---RAEPEYYKSLRISELGSSLSDEAI 128

  Fly   571 KDGLFHEYKKHGKVTWVKVVGQNSERYALVCFKKPDDVEKALEVSHDKHFFG--------CKIE- 626
            :||||||:||.|.|: ||:..:..||.|||.|:      :||:....||..|        .|||
Frog   129 EDGLFHEFKKFGDVS-VKISREGDERVALVNFR------RALDARAAKHARGRLVLYDRPLKIEA 186

  Fly   627 -------------------------------------------VEP----YQGYDVE-------- 636
                                                       :.|    |:.|.::
Frog   187 VYLNVGGTNRRRSRSPGEKDSYGGLAAAVSTLATHRHPHGQRALSPGGLGYRDYRLQQLALGRLP 251

  Fly   637 ------------DNEFRPYEAELD------------------EYHPKSTRTLFIGNLEKDITAGE 671
                        :.|:..|::.|.                  |...::.||||:|||:..:...|
Frog   252 PAPAALPRELDREREYSLYDSRLRSTYTVDPRLNFRDEDLALEIDARANRTLFVGNLDVVVKESE 316

  Fly   672 LRSHFEAFGEIIEIDIKKQG---LNAYAFCQYSDIVSVVKAMRKMDGEHLGSNRIKLGFGKSMPT 733
            :...|..||.|.|:|||:.|   ...|.|.::.::....:|...|.|:.|.|:.:|:|:||.:||
Frog   317 IYRVFGRFGTITEVDIKRAGRGQQTTYGFIKFENLDMAHRAKVAMSGKMLRSHALKIGYGKVVPT 381

  Fly   734 NCVWIDGVDEKVSESFLQSQFTRFGAVTKVSIDRNRQLALVLYDQVQNAQAAVKDMRGTIL--RR 796
            |.:|:.|:...|..:.|..:|.|||.:.::...:....|.:.|:.:..||||...|||..:  ..
Frog   382 NRLWVGGLGPWVPVTALAREFDRFGTIRQIDYRKGENWAYIQYESLDAAQAACTQMRGFPMGGDH 446

  Fly   797 KKLQVDFASRECQ----------DAFYDKQEKQQQQSSGSNPRFSRYESSASSLQSRSRASSF-- 849
            ::|:||||..:.:          ..:.|..|:.....:          |.||..:.||....|
Frog   447 RRLRVDFAEADVRFPHPYVQPLPIPYIDFGEETPGHRT----------SEASRARDRSPPLIFRD 501

  Fly   850 -SRHQNNSNDDCSPINTPGGASSGISSASNLINQSTSINISNIGTNACSAMPAPSLASAVVSCNV 913
             .|....:||..||
Frog   502 RERDAYTNNDWVSP--------------------------------------------------- 515

  Fly   914 NASGTVPASTSMPSGVSSSSSSLPMSPAALAQRHRMVRNARQTVDCDFNEVGRLRFRSSEEVSGG 978
                                      ||  ..|||:...:.:|::...:.....|.|..:||:..
Frog   516 --------------------------PA--RDRHRVTSESLETIERRADNWALDRDRERDEVNRD 552

  Fly   979 AGNSTQFEDVR---------------CDSPVTARQGSA-----------VNCFTGPTAAVGESID 1017
            .....:.:|.|               |.:|..:.:||.           |.|.:.|:    ....
Frog   553 QPRKRRLDDSRHLDRSPESDRSRKRHCVTPERSPEGSGGRDNRYNDSDRVACRSSPS----RDWK 613

  Fly  1018 GTLNNNQITGGAEGFTGSGGSILSRRR----CGKTP--KDLHPVHNQRIQLAEQVEEC------- 1069
            |:|..     |.|.......|:...||    ..|:|  ||.||..|.:::..::.|..
Frog   614 GSLER-----GQEDKHDRKNSVERERRHRVPANKSPLKKDEHPEGNSKVKPPQKSEAAHKLCLAW 673

  Fly  1070 -----------PSS-----GDEGVVS 1079
                       ||:     ||.||.|
Frog   674 QGMLLLKNSNFPSNMHLLQGDLGVAS 699

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spen	NP_722615.1	RRM2_SHARP	555..628	CDD:240795	30/124 (24%)
		RRM3_SHARP	654..726	CDD:240796	25/74 (34%)
		RRM4_SHARP	727..803	CDD:240797	24/77 (31%)
		RILP-like	1997..>2055	CDD:304877
		SPOC	5404..5527	CDD:285043
rbm15	XP_002933033.1	RRM1_RBM15	111..188	CDD:240997	30/83 (36%)
		PA	<162..>225	CDD:333703	8/62 (13%)
		RRM_SF	294..380	CDD:388407	29/85 (34%)
		RRM_SF	383..455	CDD:388407	21/71 (30%)
		SF-CC1	518..>652	CDD:273721	29/142 (20%)
		SPOC	666..833	CDD:369497	7/34 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D367857at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920