DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ScpX and Scp2

DIOPT Version :9

Sequence 1:	NP_524715.2	Gene:	ScpX / 44183	FlyBaseID:	FBgn0015808	Length:	544	Species:	Drosophila melanogaster
Sequence 2:	NP_035457.1	Gene:	Scp2 / 20280	MGIID:	98254	Length:	547	Species:	Mus musculus

Alignment Length:	528	Identity:	321/528 - (60%)
Similarity:	405/528 - (76%)	Gaps:	3/528 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 RVYVVGVGMTKFEKPGRQADVCYPDFAREAITKALQDAGIKYEEVQQAVAGYVYGDSTCGQRAIY 69
            ||:|||||||||.|||.:....|||.|:||..|||:||.|.|..|:||..||||||||.||||||
Mouse    13 RVFVVGVGMTKFMKPGGENSRDYPDMAKEAGQKALEDAQIPYSAVEQACVGYVYGDSTSGQRAIY 77

  Fly    70 -EVGMTGIPVYNVNNNCSTGSSALYLAKQIVESGNADCVLALGFEKMERGSLSSKYFDRANPMER 133
             .:|:||||:.||||||||||:||::|.|:::.|.|:||||||||||||||:.:|:.||..|.::
Mouse    78 HSLGLTGIPIINVNNNCSTGSTALFMAHQLIQGGLANCVLALGFEKMERGSIGTKFSDRTTPTDK 142

  Fly   134 HITEMGELAEIGAGPMAAQIFGNAGKEHMKKYGTKPEHFGKIAWKNHKHSVNNPYSQFRDEYTLE 198
            ||..:.:...:.|.|:..|:||.||||||:|||||.|||.||.||||||||||.||||:|||:||
Mouse   143 HIEVLIDKYGLSAHPITPQMFGYAGKEHMEKYGTKVEHFAKIGWKNHKHSVNNTYSQFQDEYSLE 207

  Fly   199 QIMKSPQVVEGVLTKLQCCPTSDGSGAAILASEAFVRRHGLEKQAVEIVGMEMASDPASTFADKS 263
            ::|||..|.: .||.|||||||||:.||||:||.||:::||:.:|||||..||.:|..|||.:||
Mouse   208 EVMKSKPVFD-FLTILQCCPTSDGAAAAILSSEEFVQQYGLQSKAVEIVAQEMMTDLPSTFEEKS 271

  Fly   264 LMKIAGTDMTRLATQRLFAKSGYKPQDVQVVELHDCFSANELITYEALGLCGEGNAGEFIDAGDN 328
            ::|:.|.||::.|.:|.:.|||..|.||.|:|||||||.||||||||||||.||..|..:|.|||
Mouse   272 IIKVVGYDMSKEAARRCYEKSGLTPNDVDVIELHDCFSVNELITYEALGLCPEGQGGTLVDRGDN 336

  Fly   329 TYGGKFVVNPSGGLISKGHPLGATGLAQCAELCWQLRGLAEKRQVPNAQLALQHNLGLGGAVVVA 393
            |||||:|:||||||||||||||||||||||||||||||.|.|||||.|::||||||||||||||.
Mouse   337 TYGGKWVINPSGGLISKGHPLGATGLAQCAELCWQLRGEAGKRQVPGAKVALQHNLGLGGAVVVT 401

  Fly   394 LYRLGFP-AANSVVRNLTAAGKAATSEDGFKVAPLLKLLEQAMQEDKDNLIEKVRAIYGFKVNNG 457
            |||:||| ||:|...:..:|...:::.||||...:.|.:|:.::|:.:..::|:..|:.|||.:|
Mouse   402 LYRMGFPEAASSFRTHQVSAAPTSSAGDGFKANLVFKEIEKKLEEEGEQFVKKIGGIFAFKVKDG 466

  Fly   458 PNGQTGFWVIDAKQGKGKIIFNGTQKCDVTFIISDDDVFELLTGKLPPQKAFFQGKIKIQGNMGF 522
            |.|:...||:|.|.|||.::.|..:|.|.|..::|.|:..|:|||:.||.||||||:||.||||.
Mouse   467 PGGKEATWVVDVKNGKGSVLPNSDKKADCTITMADSDLLALMTGKMNPQSAFFQGKLKIAGNMGL 531

  Fly   523 AMKLMDLQ 530
            ||||.:||
Mouse   532 AMKLQNLQ 539

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ScpX	NP_524715.2	PRK08256	5..396	CDD:181327	260/391 (66%)
		SCP-x_thiolase	9..395	CDD:238425	256/386 (66%)
		SCP2	429..529	CDD:280250	46/99 (46%)
Scp2	NP_035457.1	PRK08256	12..404	CDD:181327	260/391 (66%)
		nondecarbox_cond_enzymes	17..403	CDD:238422	256/386 (66%)
		SCP2	452..538	CDD:280250	43/85 (51%)
		Microbody targeting signal. /evidence=ECO:0000255, ECO:0000303\|PubMed:26901662	545..547
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831995
Domainoid	1	1.000	254	1.000	Domainoid score	I2053
eggNOG	1	0.900	-	-		E1_KOG1406
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37717
Inparanoid	1	1.050	660	1.000	Inparanoid score	I759
Isobase	1	0.950	-	0	Normalized mean entropy	S2522
OMA	1	1.010	-	-		QHG61490
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006286
OrthoInspector	1	1.000	-	-		otm43120
orthoMCL	1	0.900	-	-		OOG6_101329
Panther	1	1.100	-	-	LDO	PTHR24314
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3196
SonicParanoid	1	1.000	-	-		X4572
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	17	16.740