Protein Alignment RabX1 and RAB1B

DIOPT Version :10

• Sequence 1: NP_524713.1
• Gene: RabX1 / 44172
• FlyBaseID: FBgn0015372
• Length: 261
• Species: Drosophila melanogaster
• Sequence 2: NP_112243.1
• Gene: RAB1B / 81876
• HGNCID: 18370
• Length: 201
• Species: Homo sapiens
• Alignment Length: 180
• Identity: 69/180 - (38%)
• Similarity: 106/180 - (58%)
• Gaps: 7/180 - (3%)

  Fly     7 KVLVLGSRGVGKTRLVIRYIKNTLHRKESEVPTIAVSFFTCNIILDEVKIKLQIWDTAGQERYRA 71
            |:|::|..||||:.|::|:..:|.  .||.:.||.|.|....|.||...|||||||||||||:|.
Human    10 KLLLIGDSGVGKSCLLLRFADDTY--TESYISTIGVDFKIRTIELDGKTIKLQIWDTAGQERFRT 72

  Fly    72 VAPMYYRNANAAILVFDLTQYKTFTEIKSWIQELHRNVQDPMILTLVGNKMDMQAQRAVSREEAF 136
            :...|||.|:..|:|:|:|..:::..:|.|:||:.|...:.:...|||||.|:..::.|....|.
Human    73 ITSSYYRGAHGIIVVYDVTDQESYANVKQWLQEIDRYASENVNKLLVGNKSDLTTKKVVDNTTAK 137

  Fly   137 VFATSIGATYFETSTETDQGLEQVFISTAQGLVR-----LADEGKSPSLR 181
            .||.|:|..:.|||.:....:||.|::.|..:.:     .|..|:.|:|:
Human   138 EFADSLGIPFLETSAKNATNVEQAFMTMAAEIKKRMGPGAASGGERPNLK 187

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RabX1	NP_524713.1	Rab	7..166	CDD:206640	64/158 (41%)
RAB1B	NP_112243.1	Rab1_Ypt1	7..172	CDD:206661	65/163 (40%)
		Switch 1. /evidence=ECO:0000269|PubMed:20064470, ECO:0007744|PDB:3JZA	30..45		6/16 (38%)
		Switch 2 region, required for interaction with REP1/CHM	64..83		11/18 (61%)
		Switch 2. /evidence=ECO:0000269|PubMed:20064470, ECO:0007744|PDB:3JZA	65..80		8/14 (57%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	174..201		4/14 (29%)