DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment RabX1 and RAB5B

DIOPT Version :9

Sequence 1:	NP_524713.1	Gene:	RabX1 / 44172	FlyBaseID:	FBgn0015372	Length:	261	Species:	Drosophila melanogaster
Sequence 2:	NP_001238965.1	Gene:	RAB5B / 5869	HGNCID:	9784	Length:	215	Species:	Homo sapiens

Alignment Length:	162	Identity:	67/162 - (41%)
Similarity:	103/162 - (63%)	Gaps:	2/162 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 KVLVLGSRGVGKTRLVIRYIKNTLHRKESEVPTIAVSFFTCNIILDEVKIKLQIWDTAGQERYRA 71
            |:::||...|||:.||:|::|...|  |.:..||..:|.|.::.||:..:|.:||||||||||.:
Human    22 KLVLLGESAVGKSSLVLRFVKGQFH--EYQESTIGAAFLTQSVCLDDTTVKFEIWDTAGQERYHS 84

  Fly    72 VAPMYYRNANAAILVFDLTQYKTFTEIKSWIQELHRNVQDPMILTLVGNKMDMQAQRAVSREEAF 136
            :||||||.|.|||:|:|:|..:||...|:|::||.|.....:::.|.|||.|:..:|.|..|||.
Human    85 LAPMYYRGAQAAIVVYDITNQETFARAKTWVKELQRQASPSIVIALAGNKADLANKRMVEYEEAQ 149

  Fly   137 VFATSIGATYFETSTETDQGLEQVFISTAQGL 168
            .:|......:.|||.:|...:..:|::.|:.|
Human   150 AYADDNSLLFMETSAKTAMNVNDLFLAIAKKL 181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RabX1	NP_524713.1	Ras	7..166	CDD:278499	65/158 (41%)
RabX1	NP_524713.1	Rab	7..166	CDD:206640	65/158 (41%)
RAB5B	NP_001238965.1	Rab5_related	20..182	CDD:206653	67/162 (41%)
		Effector region. /evidence=ECO:0000255	49..57		2/7 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	186..215
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0092
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810