DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sw and PAC11

DIOPT Version :9

Sequence 1:	NP_477075.2	Gene:	sw / 44160	FlyBaseID:	FBgn0003654	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	NP_010776.1	Gene:	PAC11 / 852099	SGDID:	S000002896	Length:	533	Species:	Saccharomyces cerevisiae

Alignment Length:	698	Identity:	131/698 - (18%)
Similarity:	228/698 - (32%)	Gaps:	264/698 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MDRKAELERKKAKLAALREEKDRRRREKEIKDMEEAAGRIGGGAGIDKDQRKDLDEMLSSLGVAP 65
            |:|..:||.|:.:|..|||    ||::..:....|                        ::|..|
Yeast     1 MERLKQLEEKRRQLKELRE----RRKQASLFPGSE------------------------TMGHHP 37

  Fly    66 VSEVLSSLSSVNSMTSDNSNTQTPDASLQATVNGQSGGKKQPLNLSVYNVQATNIPPKETLVYTK 130
             :||.:..:.|               |:....:.:.|.|       :...|:..:..||.:.|.|
Yeast    38 -TEVHAKATMV---------------SVSVQTDMEEGSK-------IQEPQSAYLRRKEVITYDK 79

  Fly   131 QTQT--------------TSTGGGNGDVLSCHSSPLSGYMEDWWRPRKAHATDYYDEYNLNPGLE 181
            ..||              |:|     |.::..::......:|     ||.        |..|.||
Yeast    80 GIQTDQIEEEQLQENENHTTT-----DAVAIETTAADENNKD-----KAE--------NDQPRLE 126

  Fly   182 WEDEFTDDEESSLQNLGNGFTSKLPPGYLTHGLPTVKDVAPAITPLEIKKETEVKKEVNELSEEQ 246
            ....|..:|.::  .|.|...::|                          ||||.....:.....
Yeast   127 LAKPFLVEEAAA--TLSNASFARL--------------------------ETEVSASGQQAPSNM 163

  Fly   247 KQMIILSENFQRFVVRAGRVIERALSENVDIYTD-------YIGG-------------GDSEEAN 291
            :|.   .:|..::         ..:|||:...||       |..|             .|.:.|:
Yeast   164 QQD---KDNLMQW---------NMVSENLQSETDCDCIAQEYDPGKGVLVVVYLRLPPADLQYAS 216

  Fly   292 DERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPELVVGSYHNNEESPNEPDGVVMVWNTKFKK 356
            .|.:.:  .:|.|..|....:|..:..|                           |....|:...
Yeast   217 SEAAWS--VVNVVKCDNASGRNGLLIDM---------------------------VEFRGTRIMT 252

  Fly   357 STPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKRTP-------IQRTPLSAAAH 414
            :|....:|.:|.|:|          ||..|.:|:|:|::.|::::.|       :||..::....
Yeast   253 ATILRRYHPESNVIS----------ILLATLTGKIILYELRLKQKKPETPVVYVVQRNMVARHYF 307

  Fly   415 THPVYC-LQMVGTQNAHNVISISSDGKLCSWS---LDMLSQPQ---------------DT---LE 457
            .|||.. ::....|:...|:..:.:|.:...|   |.:|.:||               ||   .|
Yeast   308 QHPVVAVIETSSVQDQERVLVAADNGNIMELSCLDLTVLRKPQQLRPVPLSQLLSLENDTCTYTE 372

  Fly   458 LQQRQSK--AIAITSMAFPANEINSLVMGSEDGYVY------------SASRHGLRSGVNEVYER 508
            ..||.:|  .:.|..||:.:.:...:.:|.|||.:|            |...:|.:..     |.
Yeast   373 RLQRLAKFDEVGIACMAYTSEDPQYVWIGGEDGGIYKVFWDQPGPLYLSLDNNGFQPA-----EN 432

  Fly   509 HLGPITGISTHYNQLSPDFGHLFLTSSIDWTIKLWSLKDTKPLYSFE------------------ 555
            |...:||:..|::......  |.|:.|.|||::||..:..|.:....
Yeast   433 HSTRVTGLEFHWDDARRLM--LLLSCSTDWTVRLWDARAGKAIIGAPLLLGGPVLRARWLEKNNG 495

  Fly   556 -DNSDYVMDVAWSPVHPALFAAVDGSGRLDL--WNLNQDTEVPTASIV 600
             :||..:....|.           ..|||.:  |..:..|.:.||:::
Yeast   496 GENSRTLRCQVWC-----------ADGRLVVVNWAFDAKTSLYTATVI 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sw	NP_477075.2	Dynein_IC2	107..135	CDD:402922	7/41 (17%)
		WD40	316..632	CDD:421866	69/349 (20%)
		WD40 repeat	316..365	CDD:293791	4/48 (8%)
		WD40 repeat	371..409	CDD:293791	11/44 (25%)
		WD40 repeat	418..457	CDD:293791	11/60 (18%)
		WD40 repeat	469..555	CDD:293791	23/97 (24%)
		WD40 repeat	561..599	CDD:293791	8/39 (21%)
		WD40 repeat	607..633	CDD:293791
PAC11	NP_010776.1	WD40	<433..466	CDD:395323	11/34 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101571
Panther	1	1.100	-	-	LDO	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.910