DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sw and dync1i2a

DIOPT Version :9

Sequence 1:	NP_477075.2	Gene:	sw / 44160	FlyBaseID:	FBgn0003654	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	XP_017213212.2	Gene:	dync1i2a / 767729	ZFINID:	ZDB-GENE-060929-1086	Length:	626	Species:	Danio rerio

Alignment Length:	681	Identity:	333/681 - (48%)
Similarity:	441/681 - (64%)	Gaps:	96/681 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KAELERKKAKLAALREEKDRRRREKEIKDME--EAAGRIGGGAGIDKDQRKDLDEMLSSLGV--- 63
            ||||||||.:||.:||||.|:..|::.|:.|  :.|..:...:.::| :|::.|.:|.|:|:
Zfish     8 KAELERKKQRLAQIREEKKRKEEERKKKEAELKKDAVPLQDDSDLEK-KRREADALLQSMGITSD 71

  Fly    64 -----APVSEVLSSLSSVNSMTS-DNSNTQTPDASLQ-----ATVNGQSGGKKQPLNLSVYNVQA 117
                 ||:|....|:.|.:...| |:.:..|...:|.     :||...|...:.||.|::..:..
Zfish    72 VSAAPAPMSPTAKSVGSPSEAGSQDSGDGTTGPRTLHWDCDPSTVLLHSELGRGPLKLAMTKMTH 136

  Fly   118 TNIPPKETLVYTKQTQT-TSTGGGNGDVLSCHSSPLSGYMEDWWRPRKAHATDYYDEYNLNPGLE 181
            .:.||||.:.|||:||| |.|                                           |
Zfish   137 VDFPPKEVVSYTKETQTPTMT-------------------------------------------E 158

  Fly   182 WEDEFTDDEESSLQNLGNGFTSKLPPGYLTHGLPTVKDVAPAITP-LEIKKETEVKKEV-----N 240
            .:||..::||:                             ||..| .|.:||...:|:|     :
Zfish   159 QKDEEDEEEET-----------------------------PAAQPEAETEKEKPEEKQVEEALPH 194

  Fly   241 ELSEEQKQMIILSENFQRFVVRAGRVIERALSENVDIYTDYIGGGDSEEANDERSHARLSLNRVF 305
            ||:||:|..|:.||.|..|...:.|::||||||:||::.||.|....|:..:.::..:|||||.|
Zfish   195 ELTEEEKLQILHSEEFMDFFDHSTRIVERALSEHVDVFFDYSGRDMEEKEGEMQAGTKLSLNRKF 259

  Fly   306 YDERWSKNRCITSMDWSTHFPELVVGSYHNNEESPNEPDGVVMVWNTKFKKSTPEDVFHCQSAVM 370
            .|:||||.|.:|.:|||..:|||:|.||:||||:|:|||||.:|||.|:||:|||.|||||||||
Zfish   260 VDDRWSKQRVVTCLDWSPQYPELLVASYNNNEEAPHEPDGVALVWNMKYKKATPEYVFHCQSAVM 324

  Fly   371 STCFAKFNPNLILGGTYSGQIVLWDNRVQKRTPIQRTPLSAAAHTHPVYCLQMVGTQNAHNVISI 435
            |..||||:|||::||||||||||||||..:|||:||||||||||||||||:.:||||||||:|||
Zfish   325 SAAFAKFHPNLVVGGTYSGQIVLWDNRSNRRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISI 389

  Fly   436 SSDGKLCSWSLDMLSQPQDTLELQQRQSKAIAITSMAFPANEINSLVMGSEDGYVYSASRHGLRS 500
            |:|||:|||||||||||||::||..:|||::|:|||:||..::|:.|:|||||.||:|||||.|:
Zfish   390 STDGKMCSWSLDMLSQPQDSMELVFKQSKSVAVTSMSFPLGDVNNFVVGSEDGSVYTASRHGSRA 454

  Fly   501 GVNEVYERHLGPITGISTHYNQLSPDFGHLFLTSSIDWTIKLWSLKDTKPLYSFEDNSDYVMDVA 565
            |::|::|.|.||||||..|......||.|||||:|.|||:||||.|:.|||||||||||||.||.
Zfish   455 GISEMFEGHHGPITGIHCHTAAGPVDFSHLFLTASFDWTVKLWSNKNNKPLYSFEDNSDYVYDVM 519

  Fly   566 WSPVHPALFAAVDGSGRLDLWNLNQDTEVPTASIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYV 630
            ||||||||||.|||.||:||||||.||||||||:.|.|:|||||:.|:.||..:.:||..|::::
Zfish   520 WSPVHPALFACVDGLGRVDLWNLNNDTEVPTASVAVDGSPALNRLRWSQSGREIAVGDSEGQIHI 584

  Fly   631 YDVAENLAQPSRDEWSRFNTHLSEIKMNQSD 661
            |||.|.:|.|..|||:||...|.||..|:.|
Zfish   585 YDVGEQIAVPRNDEWTRFVRTLVEINENRDD 615

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sw	NP_477075.2	Dynein_IC2	107..135	CDD:402922	13/28 (46%)
		WD40	316..632	CDD:421866	217/315 (69%)
		WD40 repeat	316..365	CDD:293791	31/48 (65%)
		WD40 repeat	371..409	CDD:293791	28/37 (76%)
		WD40 repeat	418..457	CDD:293791	31/38 (82%)
		WD40 repeat	469..555	CDD:293791	52/85 (61%)
		WD40 repeat	561..599	CDD:293791	31/37 (84%)
		WD40 repeat	607..633	CDD:293791	10/25 (40%)
dync1i2a	XP_017213212.2	Dynein_IC2	126..154	CDD:402922	12/27 (44%)
		WD40	269..586	CDD:421866	217/316 (69%)
		WD40 repeat	270..317	CDD:293791	29/46 (63%)
		WD40 repeat	324..363	CDD:293791	29/38 (76%)
		WD40 repeat	372..415	CDD:293791	33/42 (79%)
		WD40 repeat	423..461	CDD:293791	22/37 (59%)
		WD40 repeat	470..509	CDD:293791	23/38 (61%)
		WD40 repeat	515..542	CDD:293791	21/26 (81%)
		WD40 repeat	561..587	CDD:293791	10/25 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573339
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	624	1.000	Inparanoid score	I842
OMA	1	1.010	-	-		QHG54336
OrthoDB	1	1.010	-	-		D1453532at2759
OrthoFinder	1	1.000	-	-		FOG0001314
OrthoInspector	1	1.000	-	-		mtm6471
orthoMCL	1	0.900	-	-		OOG6_101571
Panther	1	1.100	-	-	O	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X812
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.770