DRSC/TRiP Functional Genomics Resources

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Protein Alignment sw and Dync2i2

DIOPT Version :10

Sequence 1:NP_477075.2 Gene:sw / 44160 FlyBaseID:FBgn0003654 Length:663 Species:Drosophila melanogaster
Sequence 2:NP_001008498.2 Gene:Dync2i2 / 71820 MGIID:1919070 Length:537 Species:Mus musculus


Alignment Length:461 Identity:116/461 - (25%)
Similarity:200/461 - (43%) Gaps:50/461 - (10%)


- Green bases have known domain annotations that are detailed below.


  Fly   211 THGLPTVKDVAPAITPLEIKKETEVKKEVNELSEEQKQMIILSENFQRFVVRAGRVIERALSENV 275
            |.|:.|.:..|.|.|..:.:.:||..:|...::...:...:..|.|.|   |...::.|.|:.|.
Mouse    67 TAGIATAESSAQARTHADAQVQTEAPEEPAAMAPVSQYDTLRLEAFLR---RVEAMVIRELNNNW 128

  Fly   276 DIYTDYIGGGDSEEAN-DERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPELVVGSYHNNEES 339
            ..:     ..|..|.| .|:......|:.:.|.....:...:|.:.|::....|.......::..
Mouse   129 QSH-----AFDGYEVNWTEQQQTVSCLHTLVYPLAQGQGLHVTGISWNSTGSVLACAYGRLDDGD 188

  Fly   340 PNEPDGVVMVWNTKFKKSTPED---VFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKR 401
            .:.....|..||...:...|:.   |....||||...|....|:.|.||.|||::::||....:.
Mouse   189 WSTLKSYVCTWNLDRQGLNPQQPSVVVEVPSAVMCLAFHPTQPSHIAGGLYSGEVLVWDMSRPED 253

  Fly   402 TPIQRTPLSAAAHTHPVY-CLQMVGTQNAH--NVISISSDGKLCSW--------------SLDML 449
            ..:.||.|:...||.||| .|.:...:::|  .|:|.::|||:..|              :|.:.
Mouse   254 PLLWRTGLTDDTHTDPVYQVLWLPEPRHSHRFQVLSAATDGKVLLWRGSGAGQLRLTKGFALAVQ 318

  Fly   450 SQPQDT-LELQQRQSKAIAITSMAFPANEINSLVMGSEDGYVYSASRHG-------------LRS 500
            ..|:.| |:...|....:.:||:||.:.:.:..|:|:|.|:....|...             ||:
Mouse   319 QLPRSTKLKKPPRGETEVGVTSVAFSSFDSSLFVLGTEGGFPLKCSLASEVAALTRMPSSVPLRA 383

  Fly   501 GVNEVYERHLGPITGISTHYNQLSPDFGHLFLTSSIDWTIKLWSLKDTKPLYSFEDNSDYVMDVA 565
            .|...:..|.||:..:|     .||...:|||::..|..:.|:|:...:||.|.:.:..|:..|.
Mouse   384 PVQFTFSPHGGPVYSVS-----CSPFHRNLFLSAGTDGHVHLYSMLQAQPLTSLQLSHKYLFAVR 443

  Fly   566 WSPVHPALFAAVDGSGRLDLWNLNQDTEVPTASIVVA--GAPALNRVSWTPSGLHVCIGDEAGKL 628
            ||||.|.:|||..|.|.:.|::|.:.::.||.||...  |:|.......:.....:..||..|.:
Mouse   444 WSPVRPLVFAAASGEGDVQLFDLQKSSQKPTVSITQTQDGSPVYCLEFNSQQTQLLAAGDAKGMV 508

  Fly   629 YVYDVA 634
            .|:.::
Mouse   509 KVWQLS 514

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
swNP_477075.2 Dynein_IC2 105..135 CDD:463291
WD40 316..632 CDD:475233 94/351 (27%)
WD40 repeat 316..365 CDD:293791 8/51 (16%)
WD40 repeat 371..409 CDD:293791 12/37 (32%)
WD40 repeat 418..457 CDD:293791 13/56 (23%)
WD40 repeat 469..555 CDD:293791 27/98 (28%)
WD40 repeat 561..599 CDD:293791 15/37 (41%)
WD40 repeat 607..633 CDD:293791 4/25 (16%)
Dync2i2NP_001008498.2 WD40 50..515 CDD:441893 116/461 (25%)
DYNLL2 binding. /evidence=ECO:0000250|UniProtKB:Q96EX3 80..93 3/12 (25%)
DYNLRB1 binding. /evidence=ECO:0000250|UniProtKB:Q96EX3 107..132 7/32 (22%)
WD40 repeat 165..211 CDD:293791 7/45 (16%)
WD 1. /evidence=ECO:0000255 216..256 14/39 (36%)
WD40 repeat 223..265 CDD:293791 13/41 (32%)
WD 2. /evidence=ECO:0000255 265..309 13/43 (30%)
WD40 repeat 271..312 CDD:293791 9/40 (23%)
WD40 repeat 339..389 CDD:293791 12/49 (24%)
WD 3. /evidence=ECO:0000255 391..431 14/44 (32%)
WD40 repeat 396..433 CDD:293791 12/41 (29%)
WD 4. /evidence=ECO:0000255 434..474 14/39 (36%)
WD40 repeat 439..479 CDD:293791 17/39 (44%)
WD 5. /evidence=ECO:0000255 481..521 6/34 (18%)
WD40 repeat 486..511 CDD:293791 3/24 (13%)
Blue background indicates that the domain is not in the aligned region.

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