Protein Alignment sw and Dnai1

DIOPT Version :10

• Sequence 1: NP_477075.2
• Gene: sw / 44160
• FlyBaseID: FBgn0003654
• Length: 663
• Species: Drosophila melanogaster
• Sequence 2: NP_780347.2
• Gene: Dnai1 / 68922
• MGIID: 1916172
• Length: 701
• Species: Mus musculus
• Alignment Length: 641
• Identity: 138/641 - (21%)
• Similarity: 273/641 - (42%)
• Gaps: 121/641 - (18%)

  Fly    47 DKDQRKDL-DEMLSSLGVAPVSEVLSSLSSVNSMTSDNSN----TQTPDASLQATVNGQSGGKKQ 106
            |:.:|:.. |||           |..|..|:..:||:..|    .:..:...:|....::|.:
Mouse   109 DEGRRQHYRDEM-----------VAGSQESIKVVTSEAENLEEEEEPKEGEGEAEAEAEAGSQ-- 160

  Fly   107 PLNLSVYNVQATNIPP---------KETL---VYTKQTQTTSTGGGNGDVLSCHSSPLSGYMEDW 159
                       |:||.         :|.|   |..|:.:.|:....:.......::||
Mouse   161 -----------TDIPAAAETTEKVIEEELMAPVQPKERKLTNQFNFSERASQTFNNPL------- 207

  Fly   160 WRPRKAH-----ATDYYDEYNLNPGLEWE--DEFTDDEESSLQNLGNGFTSKLPPGYLTHGLPTV 217
             |.|:..     .|::....|     :||  |.:.|:.|..                     ...
Mouse   208 -RDRECQMEPPPRTNFSATAN-----QWEIYDAYVDELEKQ---------------------EKT 245

  Fly   218 KDVAPAITPLEIKKETEVKKEVNELSEEQKQMIILSENFQRFVVRAGRVIERALSENV--DIYTD 280
            |:...|.||  :.|:|| |..:.:|:..:.|    |::..: |.:|.:::||.:::|.  |:..|
Mouse   246 KEKEKAKTP--VAKKTE-KMAMRKLTSMESQ----SDDITK-VTQAAKIVERMVNQNTYDDVAQD 302

  Fly   281 YIGGGDSEEANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPEL-VVGSYHNNEESPNEPD 344
            :....|:.:...::....|.|.:...|:  :|...:|::.|:..:.:| .||  |.:.:...:..
Mouse   303 FKYYEDTADEYRDQEGTLLPLWKFQNDK--AKRLAVTALCWNPKYKDLFAVG--HGSYDFMKQSR 363

  Fly   345 GVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKRTPIQRTPL 409
            |::::::.| ..|.||.:|..:|.:|.......:|.|::.|.|.|.:.:::.:.....|..|:..
Mouse   364 GMLLLYSMK-NPSFPEYMFSSESGIMCLDVHVDHPYLVVVGYYDGNVAIYNLKKPHSQPCFRSTS 427

  Fly   410 SAAAHTHPVYCLQMVGTQNAHNV--ISISSDGKLCSWSL--------DM--LSQPQDTLELQQRQ 462
            .:..||.||:.::.......||:  .|:||||::.||:|        |:  |.....|.|:.:..
Mouse   428 KSGKHTDPVWQVKWQKDDMDHNLNFFSVSSDGRIVSWTLVKSELVHIDIIKLKTEGSTTEIPEGL 492

  Fly   463 SKAIAITSMAFPAN-EINSL-VMGSEDGYVYSASRHGLRSGVNEVYERHLGPITGISTHYNQLSP 525
            .........||..: ||:.: ::|:|:|.:|..|: ...|...:.|:.|...:..:     ..:|
Mouse   493 QLHTVGCGTAFDFHKEIDYMFLVGTEEGKIYKCSK-SYSSQFLDTYDAHNMAVDAV-----LWNP 551

  Fly   526 DFGHLFLTSSIDWTIKLWSLKDTKPLYSFEDNSDYVMDVAWSPVHPALFAAVDGSGRLDLWNL-- 588
            ....:|::.|.|||:|:|......|::.::.|| .|.||||:|....:||||...|:..:::|
Mouse   552 YHTKVFMSCSSDWTVKIWDHTIKTPMFIYDLNS-AVGDVAWAPYSSTVFAAVTTDGKAHVFDLAV 615

  Fly   589 NQDTEVPTASIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVYDVAENLAQPSRDE 644
            |:...:....:|......:..|.:.|....:.:||:.|.:....::.||.:..:::
Mouse   616 NKYEAICNQPVVAKKKNKITHVQFNPIHPIIIVGDDRGHIICLKLSPNLRKMPKEK 671

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sw	NP_477075.2	Dynein_IC2	105..135	CDD:463291	7/41 (17%)
		WD40	316..632	CDD:475233	81/332 (24%)
		WD40 repeat	316..365	CDD:293791	12/49 (24%)
		WD40 repeat	371..409	CDD:293791	7/37 (19%)
		WD40 repeat	418..457	CDD:293791	14/50 (28%)
		WD40 repeat	469..555	CDD:293791	21/87 (24%)
		WD40 repeat	561..599	CDD:293791	13/39 (33%)
		WD40 repeat	607..633	CDD:293791	5/25 (20%)
Dnai1	NP_780347.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..45
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	119..165		12/69 (17%)
		WD40 repeat	336..382	CDD:293791	11/48 (23%)
		WD40	<354..612	CDD:475233	67/265 (25%)
		WD 1	382..422		7/39 (18%)
		WD40 repeat	388..429	CDD:293791	8/40 (20%)
		WD 2	431..474		14/42 (33%)
		WD40 repeat	436..493	CDD:293791	15/56 (27%)
		WD40 repeat	501..538	CDD:293791	10/37 (27%)
		WD 3	539..579		10/44 (23%)
		WD40 repeat	544..581	CDD:293791	9/41 (22%)
		WD 4	581..621		15/40 (38%)
		WD40 repeat	586..627	CDD:293791	13/40 (33%)
		WD 5	629..668		7/38 (18%)