DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment sw and dic1

DIOPT Version :10

Sequence 1:NP_477075.2 Gene:sw / 44160 FlyBaseID:FBgn0003654 Length:663 Species:Drosophila melanogaster
Sequence 2:NP_001342791.1 Gene:dic1 / 5802757 PomBaseID:SPBC646.17C Length:544 Species:Schizosaccharomyces pombe


Alignment Length:508 Identity:145/508 - (28%)
Similarity:243/508 - (47%) Gaps:65/508 - (12%)


- Green bases have known domain annotations that are detailed below.


  Fly   175 NLNPGLEWEDEFTDDEESSLQNLGNGFTSKLPPGYLTHGLP-TVKDVAPAITPLEIKKETEVKKE 238
            ||.|.       |...||...||.:....|:...|.::... .|.:..|:|:.....:||  .|.
pombe    57 NLTPQ-------TYSLESKSSNLVSDCELKISSVYQSYSSTFNVSNHVPSISKTVNIRET--SKH 112

  Fly   239 VNELSEEQKQMIILS----ENFQRFVVRAGRVIERAL-SENVDIYTDYIGGGDSEEANDERSHAR 298
            :...::..|..:..|    ::...|:..:.::::||| .::..::|||.....|::...:.....
pombe   113 LKHSTKAPKCSLPTSALEIDHLNNFLHSSAKILDRALCDQSNQLFTDYTVKKKSKKNKSQLEENG 177

  Fly   299 LSLNRVFYDERWSKNRCITSMDWSTHFPELVVGSYHNNEESPNEPDGVVMVWNTKFKKSTPEDVF 363
            |:....|.||:.:.|..:.|:.:|:.|.||::.||...:|: ....|:.:|||.::|.| ||.|.
pombe   178 LNHLFTFQDEKITLNSVVNSISYSSFFEELLITSYAKPKEA-LRTRGLAIVWNQRWKNS-PESVL 240

  Fly   364 HCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKRTPIQRTPLSAAAHTHPVYCLQMVGTQN 428
            ..:|.:.....:.|:|.||.||.|:||:.|||.| |.:.|:..|.:.:..|..||..:..:....
pombe   241 KARSEITVCKPSPFHPQLIAGGAYNGQVFLWDLR-QGQYPVSFTTIISGGHLEPVTDITYINNPP 304

  Fly   429 AHNVISISSDGKLCSWSLDMLSQPQDTLELQQR---QSKAIAITSMAF-PANEINSLVMGSEDGY 489
            ::|:::.|:||.:..|..||.|:|.:|:.|..:   .|:.|..|.::| |.|.:..|| |:|||.
pombe   305 SNNIVTCSTDGLVHIWEPDMFSRPSETICLSSQVDSSSQCIPATCLSFIPENNMEFLV-GAEDGK 368

  Fly   490 VYSASRHGLRSGVNEV---------YERHLGPITGI----STHYN---QLSPDFGHLFLTSSIDW 538
            :    :.|.||..:|.         ||.|...|:||    |...|   :.:.||.   ||||.||
pombe   369 L----QRGYRSDYSETKAVQPSNVSYEGHNVFISGIDVMTSNSQNVFLEKNKDFA---LTSSFDW 426

  Fly   539 TIKLWSLKDTKPLYSFEDNSD-----------------YVMDVAWSPVHPALFAAVDGSGRLDLW 586
            |::||....::..:....::|                 .|.||.|....|..||:||..|.|:||
pombe   427 TVRLWQCSPSRNQHELVPSNDLDEQVIINSCKTFTHKAMVFDVKWCVSEPCCFASVDALGNLNLW 491

  Fly   587 NLNQDTEVPTASIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVY-DVAENLA 638
            :|.:|.|.|..|.:..|.| ||:::|.|...::..|...|.:::| .::.|||
pombe   492 DLQKDVEAPVTSDIPDGKP-LNKIAWQPEKRNLACGGLNGNVHIYKHLSPNLA 543

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
swNP_477075.2 Dynein_IC2 105..135 CDD:463291
WD40 316..632 CDD:475233 111/353 (31%)
WD40 repeat 316..365 CDD:293791 17/48 (35%)
WD40 repeat 371..409 CDD:293791 16/37 (43%)
WD40 repeat 418..457 CDD:293791 11/38 (29%)
WD40 repeat 469..555 CDD:293791 33/102 (32%)
WD40 repeat 561..599 CDD:293791 17/37 (46%)
WD40 repeat 607..633 CDD:293791 7/26 (27%)
dic1NP_001342791.1 WD40 243..536 CDD:475233 93/302 (31%)
WD40 repeat 247..289 CDD:293791 16/42 (38%)
WD40 repeat 294..339 CDD:293791 12/44 (27%)
WD40 repeat 348..390 CDD:293791 14/46 (30%)
WD40 repeat 397..453 CDD:293791 17/58 (29%)
WD40 repeat 466..504 CDD:293791 17/37 (46%)
WD40 repeat 511..535 CDD:293791 6/23 (26%)
Blue background indicates that the domain is not in the aligned region.

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