DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sw and dnai2a

DIOPT Version :9

Sequence 1:	NP_477075.2	Gene:	sw / 44160	FlyBaseID:	FBgn0003654	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	XP_017213955.1	Gene:	dnai2a / 563648	ZFINID:	ZDB-GENE-070410-46	Length:	567	Species:	Danio rerio

Alignment Length:	501	Identity:	126/501 - (25%)
Similarity:	218/501 - (43%)	Gaps:	62/501 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 PRKAHATDYYDEYNLNPGLEWEDEFTDDEESSLQNLGNGFTSKLPPGYLTHGLPTVKDVAPAITP 226
            |..:.|.:|.|....:.|.::...::..|.:....           ..::||:..|:...|
Zfish    41 PDPSLALEYIDRGTCHVGTQFSKFWSQHEVTPFHT-----------EQVSHGMNHVEGGWP---- 90

  Fly   227 LEIKKETEVKKEVNELSEEQKQMIILSENFQRFVVRAGRVIE---RALSENVDIYTDYIGGGDSE 288
                 || :....:||:...::.:...|::|:.|:....|:|   :.:.|...:|..     |:.
Zfish    91 -----ET-ISANNDELTLRYRKKVQKDESYQQTVIETVSVMENYKQKVFEKSQVYFK-----DNR 144

  Fly   289 EANDERSHARLSLNRVFYDERWSKNRCITSMDW---STHFPELVVG-SYHNNEESPNEPDGVVMV 349
            ........|...:..|..|.:..| |..||:.|   ..|  :|.|. |....:..|........:
Zfish   145 VVVKREDMASARIINVLRDPKKEK-RAATSLSWHPVDNH--KLAVAYSCVEFQRGPKNMSSDSYI 206

  Fly   350 WNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKRTPIQRTPLSAAAH 414
            ||.:..|. ||......|.::...:...|.::::||:|:|||..||.|...: |:|   :||..|
Zfish   207 WNIENNKQ-PEMTLKSVSPLVCLEYNLKNISILIGGSYNGQIGYWDTRSGSQ-PVQ---ISAIEH 266

  Fly   415 TH--PVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQQRQSK----AIAITSMAF 473
            :|  |||.:..:.|:......|.|:||::..|.:..:|:|...|.|...:||    |....||.|
Zfish   267 SHKDPVYKVIWLQTKIGTEAFSASTDGQVLFWDIRNMSEPTKQLILDPAKSKNLNNAFGAFSMEF 331

  Fly   474 PANEINSLVMGSEDGYVYSASRHGLRSGVNEV---YERHLGPITGISTHYNQLSPDFGHLFLTSS 535
            . |.:...::|:|.|.|...:|. |.:....:   |..||||:..:     |.:|.|...|||.:
Zfish   332 D-NTMPKFLVGTEQGLVVLCNRK-LETTDEPIVCTYSGHLGPVYAV-----QRNPFFPKYFLTVA 389

  Fly   536 IDWTIKLWSLKDTK--PLYSFEDNSDYVMDVAWSPVHPALFAAVDGSGRLDLWNLNQDTEVPTAS 598
             |||.::|| :|.:  .:.|.:.::.::||..||||.||:|..|...|.||:|::....:.|..|
Zfish   390 -DWTARIWS-EDIRLSSIMSTKYHTSHLMDGCWSPVRPAVFFTVKMDGTLDVWDILLKQKDPVLS 452

  Fly   599 IVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVYDVAENLAQPSRDE 644
            :.|......:......|.| :|.|.:.|.:.:..::.||.....:|
Zfish   453 LKVCDETLYSIRVKNDSPL-MCCGSQLGTVTLLKMSPNLCTLQSNE 497

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sw	NP_477075.2	Dynein_IC2	107..135	CDD:402922
		WD40	316..632	CDD:421866	96/330 (29%)
		WD40 repeat	316..365	CDD:293791	13/52 (25%)
		WD40 repeat	371..409	CDD:293791	12/37 (32%)
		WD40 repeat	418..457	CDD:293791	10/38 (26%)
		WD40 repeat	469..555	CDD:293791	28/90 (31%)
		WD40 repeat	561..599	CDD:293791	15/37 (41%)
		WD40 repeat	607..633	CDD:293791	5/25 (20%)
dnai2a	XP_017213955.1	None
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910