DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sw and dync1i2b

DIOPT Version :9

Sequence 1:	NP_477075.2	Gene:	sw / 44160	FlyBaseID:	FBgn0003654	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	XP_009300385.1	Gene:	dync1i2b / 561612	ZFINID:	ZDB-GENE-090121-1	Length:	645	Species:	Danio rerio

Alignment Length:	699	Identity:	322/699 - (46%)
Similarity:	434/699 - (62%)	Gaps:	113/699 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KAELERKKAKLAALREEKDRRRREKEIKDMEEAAGRIGGGAGIDKD-----QRKDLDEMLSSLGV 63
            ||||||||.:||.:||||.|:..|::.|:::   ||..|.:...:|     :|::.:.:|.|:|:
Zfish     8 KAELERKKQRLAQIREEKKRKEEERKKKELD---GRKEGASPPQEDSDLERKRREAEALLQSMGI 69

  Fly    64 ---------------------------APVSEVLSSLSSVNSMTSDNSNT-------QTPDASLQ 94
                                       :|.::.:.:.|...|..|.:..|       .:..::|.
Zfish    70 TDASMVQPLRVVTEDTCLFHYLVPPPMSPSAKSVGTPSETGSQDSGDGGTGPRTLHWDSDPSTLL 134

  Fly    95 ATVNGQSGGKKQPLNLSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLSCHSSPLSGYMEDW 159
            ...:.|.|  :.||.|.:..|...:.||||.:.|:|:|||
Zfish   135 LHSDSQLG--RGPLKLGMSKVTQVDFPPKEMVSYSKETQT------------------------- 172

  Fly   160 WRPRKAHATDYYDEYNLNPGLEWEDEFTDDEESSLQNLGNGFTSKLPPGYLTHGLPTVKDVAPAI 224
              |.:.|              ..|||..:::.:.:|                          |.:
Zfish   173 --PTQTH--------------HKEDEEEEEDLAVMQ--------------------------PVM 195

  Fly   225 TPLEIKKETEVKKEV--NELSEEQKQMIILSENFQRFVVRAGRVIERALSENVDIYTDYIGGGDS 287
            .|.|.|...:.:.|.  :||:||:||.|:.||.|..|...:.|::||||||.||::.||.|....
Zfish   196 EPQEEKDSQKEEDEASPHELTEEEKQQILHSEEFVTFFDHSSRIMERALSEQVDVFFDYSGRDLQ 260

  Fly   288 EEANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPELVVGSYHNNEESPNEPDGVVMVWNT 352
            ::..:.::.|:|||||.|.||||||:|.:|.:|||..:|||:|.||.:|||:|:|||||.:|||.
Zfish   261 DKEGESQAGAKLSLNRQFADERWSKHRVVTCLDWSPQYPELLVASYCSNEEAPHEPDGVALVWNM 325

  Fly   353 KFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKRTPIQRTPLSAAAHTHP 417
            |:||:|||.||||||||||..||:|:|||::||||||||||||||..||||:|||||||:|||||
Zfish   326 KYKKTTPEYVFHCQSAVMSAAFAQFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSASAHTHP 390

  Fly   418 VYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQQRQSKAIAITSMAFPANEINSLV 482
            |||:.:||||||||:||||:|||:|||||||||.|||:|||..:|||::|:|||:||..::|:.|
Zfish   391 VYCVNVVGTQNAHNLISISTDGKMCSWSLDMLSTPQDSLELVFKQSKSVAVTSMSFPLGDVNNFV 455

  Fly   483 MGSEDGYVYSASRHGLRSGVNEVYERHLGPITGISTHYNQLSPDFGHLFLTSSIDWTIKLWSLKD 547
            :|||||.||:|.|||.::|::|::|.|.|||||:..|......||.|||:|||.|||:||||.|:
Zfish   456 VGSEDGSVYTACRHGSKAGISEMFEGHHGPITGLDCHTAAGPVDFSHLFVTSSFDWTVKLWSTKN 520

  Fly   548 TKPLYSFEDNSDYVMDVAWSPVHPALFAAVDGSGRLDLWNLNQDTEVPTASIVVAGAPALNRVSW 612
            .|||||||||||||.||.|||.||||||.|||.|.|||||||.:|||||||:.|.|.||||||.|
Zfish   521 NKPLYSFEDNSDYVYDVMWSPTHPALFACVDGVGHLDLWNLNNETEVPTASVTVEGNPALNRVRW 585

  Fly   613 TPSGLHVCIGDEAGKLYVYDVAENLAQPSRDEWSRFNTHLSEIKMNQSD 661
            ..||..|.:||..|:|::|||.|.::.|.:|||:||...|:||..|:.|
Zfish   586 AHSGREVAVGDSEGQLHIYDVGEQISVPRQDEWTRFVRTLTEINENRED 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sw	NP_477075.2	Dynein_IC2	107..135	CDD:402922	12/27 (44%)
		WD40	316..632	CDD:421866	213/315 (68%)
		WD40 repeat	316..365	CDD:293791	30/48 (63%)
		WD40 repeat	371..409	CDD:293791	28/37 (76%)
		WD40 repeat	418..457	CDD:293791	30/38 (79%)
		WD40 repeat	469..555	CDD:293791	49/85 (58%)
		WD40 repeat	561..599	CDD:293791	29/37 (78%)
		WD40 repeat	607..633	CDD:293791	13/25 (52%)
dync1i2b	XP_009300385.1	Dynein_IC2	145..173	CDD:288403	13/54 (24%)
		Spore_coat_CotO	153..>256	CDD:290858	43/169 (25%)
		WD40	283..605	CDD:295369	217/321 (68%)
		WD40 repeat	289..338	CDD:293791	30/48 (63%)
		WD40 repeat	343..382	CDD:293791	29/38 (76%)
		WD40	362..>606	CDD:225201	165/243 (68%)
		WD40 repeat	391..434	CDD:293791	33/42 (79%)
		WD40 repeat	442..490	CDD:293791	27/47 (57%)
		WD40 repeat	497..528	CDD:293791	21/30 (70%)
		WD40 repeat	534..575	CDD:293791	30/40 (75%)
		WD40 repeat	580..606	CDD:293791	13/25 (52%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573347
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37921
Inparanoid	1	1.050	624	1.000	Inparanoid score	I842
OMA	1	1.010	-	-		QHG54336
OrthoDB	1	1.010	-	-		D1453532at2759
OrthoFinder	1	1.000	-	-		FOG0001314
OrthoInspector	1	1.000	-	-		mtm6471
orthoMCL	1	0.900	-	-		OOG6_101571
Panther	1	1.100	-	-	LDO	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X812
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.910