DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sw and dnai1.2

DIOPT Version :9

Sequence 1:	NP_477075.2	Gene:	sw / 44160	FlyBaseID:	FBgn0003654	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	NP_001074027.1	Gene:	dnai1.2 / 555705	ZFINID:	ZDB-GENE-070112-1302	Length:	660	Species:	Danio rerio

Alignment Length:	659	Identity:	150/659 - (22%)
Similarity:	279/659 - (42%)	Gaps:	116/659 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 LSSVNSMTSDNSNTQTPDASLQATVNG-QSGGKKQPLNLSVYNVQA-------TNIPPKETLVYT 129
            :.:|.|..|.|.||| |.|.:   |.| ::.|||:.....:.....       |.:.|.:.|..|
Zfish     7 VGTVKSKQSPNVNTQ-PKAPV---VKGVKTTGKKKDEEEGIDTADGEEWMQGKTLVKPPDQLDLT 67

  Fly   130 KQ------TQTTSTGGGNG--------------------DVLSCHSSPLSGYM----EDWWRPRK 164
            ::      |:..:....|.                    |.::.|.. |.|.:    .|..|...
Zfish    68 EEELKEEITRVLTANNPNAPQNVVRYSFKEGCYKTIVFVDQMAIHFE-LEGNLVHKESDEGRRLM 131

  Fly   165 AHATDYYD--------EYNLNPGLEWED-----EFTDDEESSLQNLGNGFTSKLPPGYLTHGLPT 216
            |..|:..|        ...:.||...:.     .|.|....:|.||....:.:..|.      |.
Zfish   132 AKHTEREDCGGDERLENVPIKPGKREQKVTNQFNFIDRASQTLNNLPREISCQTEPP------PR 190

  Fly   217 VKDVAPA---------ITPLEIKKETEVKKEV----NELSEEQKQMI---ILSENFQRFVVRAGR 265
            ....|.|         :..|:.:::::.|:|.    .|....:|:||   ..|::..: :.:...
Zfish   191 ANFSATANQWEIYDFYVEELQRREKSKEKQESQFPNKEEDRSKKKMIQAEAQSDDISQ-LAKPAE 254

  Fly   266 VIERALSENV--DIYTDYIGGGDSEEANDE---RSHARLSLNRVFYDERWSKNRCITSMDWSTHF 325
            :|||.:::|:  ::..|::   ..|:|.||   .....|.|.:..||:  :|...:|::.|:..:
Zfish   255 IIERMVNQNIFDEVAQDFM---YFEDAADEFRGEKGTLLPLWKFQYDK--AKGLSVTALCWNHIY 314

  Fly   326 PELV---VGSYHNNEESPNEPDGVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTY 387
            .:|.   :|||    |...:..|:::.:..| ..|.||.:|:..|.||.....:....|:..|.|
Zfish   315 SDLFAVGLGSY----EFTQQERGMLLFYTLK-NPSFPEFIFNTDSGVMCVDIHEQLSYLVAVGLY 374

  Fly   388 SGQIVLWDNRVQKRTPIQRTPLSAAAHTHPVYCL--QMVGTQNAHNVISISSDGKLCSWSL---- 446
            .|.:.::|.|.:...|:..:..|:..||..|:.:  |.....:.||..|:|:||::.||:|
Zfish   375 DGCVSVYDLRKKSDQPMYNSIASSGKHTGAVWQVKWQKDDLDSNHNFFSVSTDGRVVSWTLVKHE 439

  Fly   447 ----DMLS-QPQDTLELQQRQSKAIAITSMAFPANEINSLVMGSEDGYVYSASRHGLRSGVNEVY 506
                |::. .|.|.:....:...|.|.||:.|...:.:..::|:|.|.::..|:: ..|...|:|
Zfish   440 IVFTDIIKLPPVDKVPDDLKNVVATAGTSLDFHKQKDHHFLVGTEAGKIHKGSKY-YSSKFLEMY 503

  Fly   507 ERHLGPITGISTHYNQLSPDFGHLFLTSSIDWTIKLWSLKDTKPLYSFEDNSDYVMDVAWSPVHP 571
            :.|.  :|.....:|...|   ::|::...||.:|:|......|:::||..|. |.||||||...
Zfish   504 DAHF--MTVSCVRWNPFHP---NVFISCGWDWMVKIWDHTINSPVFTFELKSS-VTDVAWSPHSS 562

  Fly   572 ALFAAVDGSGRLDLWNLN-QDTEVPTASIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVYDVAE 635
            .:||||...|::.:::|: ...|......||:....|..:.:.|....:.:||:.|::....::.
Zfish   563 TVFAAVTADGKVHVFDLSINKYEALCQQKVVSKKTRLLHIEFNPVHPIIIVGDDRGRVISLKLSP 627

  Fly   636 NLAQPSRDE 644
            ||.:..:::
Zfish   628 NLRKKPKEK 636

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sw	NP_477075.2	Dynein_IC2	107..135	CDD:402922	5/40 (13%)
		WD40	316..632	CDD:421866	86/330 (26%)
		WD40 repeat	316..365	CDD:293791	13/51 (25%)
		WD40 repeat	371..409	CDD:293791	7/37 (19%)
		WD40 repeat	418..457	CDD:293791	14/49 (29%)
		WD40 repeat	469..555	CDD:293791	20/85 (24%)
		WD40 repeat	561..599	CDD:293791	14/38 (37%)
		WD40 repeat	607..633	CDD:293791	5/25 (20%)
dnai1.2	NP_001074027.1	WD40	<296..650	CDD:225201	91/355 (26%)
		WD40	354..620	CDD:295369	73/272 (27%)
		WD40 repeat	357..397	CDD:293791	8/39 (21%)
		WD40 repeat	405..485	CDD:293791	20/79 (25%)
		WD40 repeat	511..547	CDD:293791	8/38 (21%)
		WD40 repeat	552..591	CDD:293791	14/38 (37%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810