Protein Alignment sw and LOC4576277

DIOPT Version :10

• Sequence 1: NP_477075.2
• Gene: sw / 44160
• FlyBaseID: FBgn0003654
• Length: 663
• Species: Drosophila melanogaster
• Sequence 2: XP_001237748.2
• Gene: LOC4576277 / 4576277
• VectorBaseID: AGAMI1_000491
• Length: 693
• Species: Anopheles gambiae
• Alignment Length: 719
• Identity: 144/719 - (20%)
• Similarity: 253/719 - (35%)
• Gaps: 215/719 - (29%)

  Fly    58 LSSLGVAPVSEVL----SSLS----SVNSMTSDNSNTQTPDASLQATVNGQSGGKKQPLNLSVYN 114
            :||...||.|:.:    :|||    |.:....|..|.......||..::|..   :.|.||:
Mosquito     1 MSSSHAAPSSKSVKFYSASLSAGAASDSKFVVDIVNRLEERNRLQVPIDGVD---RTPANLA--- 59

  Fly   115 VQATNIPP---KETLVYTKQTQTTSTGGGNGDVLSCHSSPLSGYMEDWWRPRKAHATDYYDEYNL 176
                  ||   :|..|:::..:              ...||:..|||...| .|...|.:|.:..
Mosquito    60 ------PPFFGEEAFVWSRFRE--------------QFHPLANDMEDATVP-TADKPDGFDNFET 103

  Fly   177 NPGLEWEDEFTDDEESSLQNLGNGFTSKLPPGYLTHGLPTVKDVAPAITPLEIKKETEVKKEVNE 241
            .|..|   ...|....||:.....:..|:       .|....|:....:|..:     |..:..|
Mosquito   104 QPNYE---GVIDRRSPSLEAGQKTYHVKI-------RLTETDDIVLFESPSHV-----VSLDAEE 153

  Fly   242 LSEEQKQMIILSENFQRFVVR--AGRVIE------------RALS-------------ENVDIYT 279
            .:..|:|.       :||..|  |.|..:            |:::             .|.|:|.
Mosquito   154 AARVQEQN-------RRFETRPKARRTADAEAQTRDLPCKSRSVNTECIHRQDVASFVSNYDMYD 211

  Fly   280 DY---------IGGGDSEEANDERSHARLSLNRVFYDERWSKN---------------------- 313
            .|         |...||....:..:::|..:..:  |||.::|
Mosquito   212 TYNDLERHTKEINVADSASKLEITTYSREGMEDI--DERLNRNANFHLSSMILQRLLAGNVYREQ 274

  Fly   314 ------------------------------------RCITSMDWSTHFPELVVGSY--HNNEESP 340
                                                :.:.|..|.....::|..:|  :.:..|.
Mosquito   275 QIRFRNMYPPDPCREDIRYLYRLDVLWTYRTVETLGKPVASASWCPANGDIVALAYGIYGHTGSD 339

  Fly   341 NEPDGVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKRTPIQ 405
            :...|.|.|||.| ....||..:.....|....|::..|.|:..|.|.|::     :|:..|...
Mosquito   340 DRGCGFVYVWNIK-NPVNPERRYRFDCPVTCVAFSRRTPQLLAVGLYDGRV-----QVRDITDTT 398

  Fly   406 RTPLSAAAHT-----HPVYCLQMVGTQN--AHNVISISSDGKLCSWSLD----MLSQPQDTLELQ 459
            :|||:.:...     .|::.|:.|...|  ...||::|.:|.:..::|.    :|..|...|:..
Mosquito   399 QTPLAVSNRDRFPVYQPIWDLKWVEFDNEGKDEVIAVSQNGWVMKYTLTIGQYLLPYPLLRLDRV 463

  Fly   460 QRQSKAIAITSMAFPAN----------------------EINSLVMGSEDGYVYSASRHGLRSGV 502
            :...:....|..:.||:                      :.:...:|:::|.|:..|       :
Mosquito   464 EGTPEGQTSTGTSAPADQQPVRVQSDLHPQALCVTIHPVQKDKYYIGTDEGAVHWCS-------I 521

  Fly   503 NEVYERHLGPI----TGI-STHYNQLSPDFGHLFLTSSIDWTIKLWSLKDTKPLYSFEDNSDYVM 562
            |:.:: |||.:    .|| ...|:..||   .:|||.|.||:|::|..:..:|:.:.......:.
Mosquito   522 NDPFQ-HLGVLQMHSRGIFCLEYSPWSP---RIFLTCSGDWSIRIWIEELPEPIVTLCTGFAPIQ 582

  Fly   563 DVAWSPVHPALFAAVDGSGRLDLWNLNQDTEVPTASIVVAG-APALNRVSWTPSGLHVCIGDEAG 626
            ...|||.:..:.|:|..|| :.||:|.:.:..|.:...:.. ..||..|.:|..|..:.:||..|
Mosquito   583 AAYWSPTNSTVIASVTRSG-VQLWDLKRRSSKPASETTLGSLTTALTVVRFTNCGRCLLVGDAEG 646

  Fly   627 KLYV 630
            |.:|
Mosquito   647 KAHV 650

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sw	NP_477075.2	Dynein_IC2	105..135	CDD:463291	7/32 (22%)
		WD40	316..632	CDD:475233	83/356 (23%)
		WD40 repeat	316..365	CDD:293791	13/50 (26%)
		WD40 repeat	371..409	CDD:293791	9/37 (24%)
		WD40 repeat	418..457	CDD:293791	10/44 (23%)
		WD40 repeat	469..555	CDD:293791	25/112 (22%)
		WD40 repeat	561..599	CDD:293791	11/37 (30%)
		WD40 repeat	607..633	CDD:293791	9/24 (38%)
LOC4576277	XP_001237748.2	WD40	<294..650	CDD:441893	82/373 (22%)
		WD40 repeat	368..406	CDD:293791	11/42 (26%)
		WD40 repeat	416..489	CDD:293791	14/72 (19%)
		WD40 repeat	497..533	CDD:293791	8/43 (19%)
		WD40 repeat	538..574	CDD:293791	13/38 (34%)
		WD40 repeat	581..621	CDD:293791	11/40 (28%)
		WD40 repeat	627..664	CDD:293791	9/24 (38%)