DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sw and dync1i2

DIOPT Version :9

Sequence 1:	NP_477075.2	Gene:	sw / 44160	FlyBaseID:	FBgn0003654	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	XP_012825730.1	Gene:	dync1i2 / 407935	XenbaseID:	XB-GENE-960812	Length:	655	Species:	Xenopus tropicalis

Alignment Length:	709	Identity:	326/709 - (45%)
Similarity:	439/709 - (61%)	Gaps:	123/709 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 KAELERKKAKLAALREEKDRRRREKEIK--DMEEAAGRIGGGAGIDKDQRKDLDEMLSSLGV--- 63
            ||||||||.:||.:||||.|:..||:.|  |.::.|......:.::| :|::.:.:|.|:|:
Frog     8 KAELERKKQRLAQIREEKKRKEEEKKKKETDQKKDAAPTQEESDLEK-KRREAEALLQSMGITAE 71

  Fly    64 --------------------------APVSEVLSSLSSVNS---------------MTSDNSNTQ 87
                                      :|.|:.:|:.|...|               :|:...:..
Frog    72 PPMAVQPLRIVTEDTCLFHYLVPPPTSPSSKSVSTPSEAGSQDSGDGAGGASGRTAVTTKTLHWD 136

  Fly    88 TPDASLQATVNGQSGGKKQPLNLSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLSCHSSPL 152
            |..:.||...:...|  :.|:.|.:..|...:..|:||:.|||:|||
Frog   137 TDPSVLQLHSDSDMG--RGPIKLGMSKVTQVDFAPRETVSYTKETQT------------------ 181

  Fly   153 SGYMEDWWRPRKAHATDYYDEYNLNPGLEWEDEFTDDEESSLQNLGNGFTSKLPPGYLTHGLPTV 217
                                     |.|..::|..:|||.:
Frog   182 -------------------------PILAQDNEGDEDEEET------------------------ 197

  Fly   218 KDVAPAITPLE-----IKKETEVKKEVNELSEEQKQMIILSENFQRFVVRAGRVIERALSENVDI 277
              |||....::     .|||.:.:...:||:||:||.||.||.|..|...:.|::||||||:|:|
Frog   198 --VAPKAVAIQEEDKPEKKEEKTEAPPHELTEEEKQQIIHSEEFVSFFDHSTRIVERALSEHVNI 260

  Fly   278 YTDYIGGGDSEEANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPELVVGSYHNNEESPNE 342
            :.||.|....|:..:.::.|:||.||.|:||||||:|.::.:|||:.:|||:|.||:|||::|:|
Frog   261 FFDYSGRDLEEKEGEIQAGAKLSFNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNNEDAPHE 325

  Fly   343 PDGVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKRTPIQRT 407
            ||||.:|||.|:||.|||.||||||||||..||:|:|||::||||||||||||||..||||:|||
Frog   326 PDGVALVWNMKYKKMTPEYVFHCQSAVMSAAFARFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRT 390

  Fly   408 PLSAAAHTHPVYCLQMVGTQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQQRQSKAIAITSMA 472
            |||||||||||||:.:||||||||:||||:|||:|||||||||||||::||..:||||:|:|.|:
Frog   391 PLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSQPQDSMELVHKQSKAVAVTCMS 455

  Fly   473 FPANEINSLVMGSEDGYVYSASRHGLRSGVNEVYERHLGPITGISTHYNQLSPDFGHLFLTSSID 537
            ||..::|:.|:|||:|.||:|.|||.::|::|::|.|.||||||..|....:.||.|||:|||.|
Frog   456 FPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHSAVGAVDFSHLFVTSSFD 520

  Fly   538 WTIKLWSLKDTKPLYSFEDNSDYVMDVAWSPVHPALFAAVDGSGRLDLWNLNQDTEVPTASIVVA 602
            ||:|||:.|:.|||||||||||||.||.|||.||||||.|||.|||||||||.|||||||||.|.
Frog   521 WTVKLWTTKNNKPLYSFEDNSDYVYDVMWSPTHPALFACVDGVGRLDLWNLNNDTEVPTASITVE 585

  Fly   603 GAPALNRVSWTPSGLHVCIGDEAGKLYVYDVAENLAQPSRDEWSRFNTHLSEIKMNQSD 661
            |.||||||.||.||..:.:|:..|::::|||.|.:|.|..|||:||...|:||..|::|
Frog   586 GNPALNRVRWTHSGREIAVGNSEGEIFIYDVGEQIAVPRNDEWTRFARTLAEINANRAD 644

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sw	NP_477075.2	Dynein_IC2	107..135	CDD:402922	11/27 (41%)
		WD40	316..632	CDD:421866	213/315 (68%)
		WD40 repeat	316..365	CDD:293791	29/48 (60%)
		WD40 repeat	371..409	CDD:293791	28/37 (76%)
		WD40 repeat	418..457	CDD:293791	31/38 (82%)
		WD40 repeat	469..555	CDD:293791	47/85 (55%)
		WD40 repeat	561..599	CDD:293791	31/37 (84%)
		WD40 repeat	607..633	CDD:293791	11/25 (44%)
dync1i2	XP_012825730.1	Dynein_IC2	154..182	CDD:288403	12/70 (17%)
		WD40 repeat	299..346	CDD:293791	27/46 (59%)
		WD40	372..>616	CDD:225201	166/243 (68%)
		WD40	397..>622	CDD:295369	147/224 (66%)
		WD40 repeat	451..498	CDD:293791	23/46 (50%)
		WD40 repeat	506..538	CDD:293791	20/31 (65%)
		WD40 repeat	544..582	CDD:293791	31/37 (84%)
		WD40 repeat	590..616	CDD:293791	11/25 (44%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	376	1.000	Domainoid score	I857
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H37921
Inparanoid	1	1.050	613	1.000	Inparanoid score	I890
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1453532at2759
OrthoFinder	1	1.000	-	-		FOG0001314
OrthoInspector	1	1.000	-	-		mtm9426
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X812
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	8.060