DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sw and CG14838

DIOPT Version :9

Sequence 1:	NP_477075.2	Gene:	sw / 44160	FlyBaseID:	FBgn0003654	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	NP_648138.1	Gene:	CG14838 / 38851	FlyBaseID:	FBgn0035799	Length:	1132	Species:	Drosophila melanogaster

Alignment Length:	727	Identity:	138/727 - (18%)
Similarity:	230/727 - (31%)	Gaps:	285/727 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 NVQATNIPPKETLVYTKQTQTTSTGGGNGDVLSCHSSPLSGYMEDWWRPRKAHATDYYDEYNLNP 178
            ||...:.|||    ..::.||..|...|.                 |       :.|..|.: :.
  Fly   269 NVSVQSAPPK----IEREQQTNPTFPSNA-----------------W-------SQYLYEID-DE 304

  Fly   179 GLEWEDEFTDDEESSLQNLGNGFTSKLPPGYLTHGLPTVKDVAPAITPLEIKKETEV---KKEVN 240
            .||.::...|:||...:       ::..||  |:       |.|...|.|:..:.|:   ..|.|
  Fly   305 DLELDETDVDEEEEKKK-------AQAKPG--TY-------VEPEKKPPEMSAQIEMLLNTLEFN 353

  Fly   241 ELSEEQKQMIILSENFQRFVVRAGRVIERALSENVDIYTD-YIGGGDSEE----ANDERSHARLS 300
            ::...:....::|                  |..|..||: |:     :|    ||..:|:.|.
  Fly   354 QIDSYRDDYSLIS------------------SRQVVQYTNPYL-----QEFLCFANISKSNKRF- 394

  Fly   301 LNRVFYDERWSKNRCITSMDWSTHFPELVVGSYHNN-----EESPNEPDGV---------VMVW- 350
                           :...||......|:..||..:     .|:.|..|.|         |::|
  Fly   395 ---------------VAGYDWYPKLSGLIAVSYAFSTPATVNEATNRVDYVQRAVLEPNPVLLWS 444

  Fly   351 ---NTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWD--NRVQKRTPIQRTPLS 410
               |..:|..     |.......:..|..||.:::|||:.:||:||||  .|.:|..  :...|:
  Fly   445 FSDNLNYKLE-----FEAPIETTALTFCPFNGDILLGGSKNGQVVLWDLQGRCEKLD--EEEYLT 502

  Fly   411 AAAHTHPVYCLQMVG-------------------------------------------------- 425
            ||...:.:    |:|
  Fly   503 AAQAKYRI----MIGEFLNWTIDIEDNVIVPATISLLDCSPKGAITAFYWLGRSIYLSQFGKVYN 563

  Fly   426 ---TQNAHN-VISISSDGKLCSWSLD--------------MLSQPQDTLELQQRQS--KAIAIT- 469
               .:|.|. .::.:.||.:..|.||              ||.:     ||.|.:|  |::.|.
  Fly   564 DPDIRNHHKFFVTCAFDGTISFWDLDGKGGKSAKDKMRNRMLPK-----ELTQSESAFKSMVIKP 623

  Fly   470 --SMAFP------------------------ANEIN---------------SLVMGSEDGYVYSA 493
              ::.||                        ||..|               |:::.:..|:|...
  Fly   624 TYNLYFPEPITGIIADTSCLSCLTPVAKLIQANPSNYPIKTIAKDPPTMRQSMIVSTFYGHVSRI 688

  Fly   494 SRHG--LRSGVNEVYER-------HLGPITGISTHYNQLSPDFGHLFLTSSIDWTI-KLWSLK-D 547
            ...|  ......||...       |.||:..:     :.:|.:..||  :||..|| .:|... :
  Fly   689 DWQGTYTEGEATEVINSSIPFAMVHDGPVVMV-----KKNPFYPELF--ASIGRTILAIWKEDYN 746

  Fly   548 TKPLYSFEDNSDYVMDVAWSPVHPALFAAVDGSGRLDLWNL---NQD---TEVPTASIVVA---G 603
            ..|::..:...| :..||||...||:.......|.|:.|::   :.|   ||:....|:.|   .
  Fly   747 YSPIFWRKRACD-LTAVAWSETRPAVLYLTRIDGILEAWDILARDDDACLTEILGGGIITAITEH 810

  Fly   604 APALN-------------RVSWTPSGLHVCIGDEAGKLYVYDVAENLAQPSRDEWSR----FNTH 651
            .|:|.             |:...|....|.:.:|..:|..|.:.|...:.....|.:    .|..
  Fly   811 RPSLPHKILGIGDYNSSIRMVKLPHSFDVPLPNELDQLIKYVLKEERRKMGIQSWEQKYYELNKD 875

  Fly   652 LSEIKMNQSDEV 663
            :.|.|...:.|:
  Fly   876 IIEAKREAAAEI 887

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sw	NP_477075.2	Dynein_IC2	107..135	CDD:402922	6/20 (30%)
		WD40	316..632	CDD:421866	93/480 (19%)
		WD40 repeat	316..365	CDD:293791	14/66 (21%)
		WD40 repeat	371..409	CDD:293791	14/39 (36%)
		WD40 repeat	418..457	CDD:293791	11/106 (10%)
		WD40 repeat	469..555	CDD:293791	23/138 (17%)
		WD40 repeat	561..599	CDD:293791	12/43 (28%)
		WD40 repeat	607..633	CDD:293791	7/38 (18%)
CG14838	NP_648138.1	WD40	328..>599	CDD:225201	59/327 (18%)
		WD40 repeat	462..505	CDD:293791	16/44 (36%)
		WD40 repeat	510..547	CDD:293791	2/40 (5%)
		RE_R_Pab1	807..>863	CDD:286594	9/55 (16%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45435269
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840