DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sw and CG13930

DIOPT Version :9

Sequence 1:	NP_477075.2	Gene:	sw / 44160	FlyBaseID:	FBgn0003654	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	NP_647645.1	Gene:	CG13930 / 38210	FlyBaseID:	FBgn0035256	Length:	685	Species:	Drosophila melanogaster

Alignment Length:	708	Identity:	139/708 - (19%)
Similarity:	250/708 - (35%)	Gaps:	209/708 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 KKAKLAALREEKDRRRREKEIKDMEEAAGRIGGGAGIDKDQRKDLDEMLSSLGVAPVSEVLSSLS 74
            :|..:..|.|    ||....:.|.||       |..:.:|.|| .||:||.             :
  Fly   109 RKTPIVVLFE----RRSMTALADTEE-------GRQVMEDNRK-YDELLSG-------------T 148

  Fly    75 SVNSMTSDNSNTQTPDASLQATVNGQSGGKKQPLNLSVYNVQATNIPPKETLVYTKQTQTTSTGG 139
            .....|.| ::|||..|.:                             |..||.|::..|...|
  Fly   149 DKTRRTVD-ADTQTMTALM-----------------------------KSRLVNTERLTTAQMG- 182

  Fly   140 GNGDVLSCHSSPLSGYMEDWWRPRKAHATDYYDEYNLNPGLEWEDEFTDDEES--SLQNLGNGFT 202
                          .|:.::         :.||.|            ||.|:|  |:|..|   .
  Fly   183 --------------SYVSNF---------EMYDTY------------TDLEKSTTSVQVQG---A 209

  Fly   203 SKLP------------------PGYLTHGLPTVKDVAPAITPLEIKKETEVKKEVNELSEEQKQM 249
            .|:.                  ||:....:.|::.:|..:...:.::...:... :.|:|:.|
  Fly   210 KKMEITTYHVGGVDQFVGINCLPGFRLALMLTMRILASNVFEPQQRRYRNMAPP-DPLAEDVK-- 271

  Fly   250 IILSENFQRFVVRAGRVIERALSENVDIYTDYIGGGDSEEANDERSHARLSLNRVFYDERWSKNR 314
                     |..|.| ::.|.                |..::|.:.|..:|          ..:.
  Fly   272 ---------FKYRLG-LLWRL----------------SPPSSDPKVHQAVS----------DMSF 300

  Fly   315 CITSMDWSTHFPELVVGSYHNNEESPNEPDGVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNP 379
            |.::.|    ...:..|.|.:.:.|.....|.|.|||.| ....||..:|.|..|::..|:...|
  Fly   301 CPSNGD----IMAVAYGVYSHGKVSKLPRSGWVYVWNIK-NPVNPERRYHYQVPVVTVEFSPTQP 360

  Fly   380 NLILGGTYSGQIVLWDNRVQKRTPIQRTPLSAAAHTHPVYCLQM------VGTQNAH--NVISIS 436
            .|:..|.::|.:.:.|...|...|:..:...::.:..||..::.      ||.:|.|  ..::.|
  Fly   361 QLLAIGLHNGGVEVRDISGQDLPPLAVSQRLSSPYFEPVTAIKWIYFEGDVGCRNPHITPFLATS 425

  Fly   437 SDGKLCSWSL----DMLSQPQDTL-----ELQ----QRQSKAIAITSMAFPANEINSLVMG---- 484
            ..|.:..:.|    :||...|..|     ||:    :||..|.::.:...|  :...:|:.
  Fly   426 QAGAVTKYRLINSPNMLGLEQQRLQRAEGELEGIPIERQPPAASLLANRHP--QCLEIVLDPVQS 488

  Fly   485 ------SEDGYVYSAS-----RHGLRSGVNEVYERHLGPITGISTHYNQLSPDFGHLFLTSSIDW 538
                  :::|.:|..|     :|      .|:.:.|.||...:     :.||....::||...||
  Fly   489 DIYYVLTDEGTLYKCSTNYPLQH------LELRQVHDGPAACM-----EFSPWSPRMYLTCGSDW 542

  Fly   539 TIKLWSLKDTKPLYSFEDNSDYVMDVAWSPVHPALFAAVDGSGRLDLWNLNQDTEVPTASIVVAG 603
            .|::|......|:.:.:.:...|....||..|..:..::..| .:|:|:|...|..|.:|.|:..
  Fly   543 CIRIWLAGILLPIVTLQHHLSPVHCARWSRTHSTILVSLSRS-TVDIWDLRNSTMKPVSSTVIDA 606

  Fly   604 APALNRVSWTPSGLHVCIGDEAGKLYVYDVAENLAQPSRDEWSRFNTHLSEIKMNQSD 661
            ........:|..|..:.:|:|||.|.:... |::..|...::.:....:.:....|.|
  Fly   607 DIFYTTFKFTHCGRSLAVGNEAGNLLMLSF-EDMPFPPHFQYKQLKRAIFKALSMQPD 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sw	NP_477075.2	Dynein_IC2	107..135	CDD:402922	4/27 (15%)
		WD40	316..632	CDD:421866	79/351 (23%)
		WD40 repeat	316..365	CDD:293791	12/48 (25%)
		WD40 repeat	371..409	CDD:293791	8/37 (22%)
		WD40 repeat	418..457	CDD:293791	12/55 (22%)
		WD40 repeat	469..555	CDD:293791	19/100 (19%)
		WD40 repeat	561..599	CDD:293791	10/37 (27%)
		WD40 repeat	607..633	CDD:293791	7/25 (28%)
CG13930	NP_647645.1	WD40	<279..648	CDD:225201	87/414 (21%)
		WD40 repeat	295..344	CDD:293791	14/63 (22%)
		WD40 repeat	350..397	CDD:293791	9/46 (20%)
		WD40 repeat	400..473	CDD:293791	16/72 (22%)
		WD40 repeat	478..513	CDD:293791	5/40 (13%)
		WD40	<518..>593	CDD:295369	20/80 (25%)
		WD40 repeat	524..560	CDD:293791	9/40 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45435315
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840