DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sw and CG9313

DIOPT Version :9

Sequence 1:	NP_477075.2	Gene:	sw / 44160	FlyBaseID:	FBgn0003654	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	NP_001286657.1	Gene:	CG9313 / 37374	FlyBaseID:	FBgn0034566	Length:	740	Species:	Drosophila melanogaster

Alignment Length:	741	Identity:	148/741 - (19%)
Similarity:	267/741 - (36%)	Gaps:	181/741 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 REEKDRRRREKEIKDMEEAAGRIGGGAGID-------------KDQRKDLDEMLSSLGVAPVSEV 69
            ::.|.:.|..|...|     |..|||...|             .|.:.||.|  :.||    .|:
  Fly    11 KQVKGKLRTSKNKTD-----GPGGGGGDADDFDAWMKSRQLLKPDDQLDLTE--AELG----EEI 64

  Fly    70 LSSLSSVNSMTSDN-----------------SNTQTPDASLQATVNGQSG-GKKQ---------P 107
            ...|:..|:....|                 .||.|..|....:::..|. |::|         |
  Fly    65 TKVLTPTNTNIVRNLVVYSFKEGEFVPAPLPGNTVTLIAFAGNSLHVDSDEGRRQIEESDEIGYP 129

  Fly   108 LNLSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLSCHSSPLSGYMEDWWRPRKAHATDYYD 172
            |.:..|.|             .:|.:|.:..|..|:          |..:|.....|..|.:..|
  Fly   130 LPMPNYTV-------------VEQRETDNVDGEEGE----------GEEDDDGATAKDAAVEDED 171

  Fly   173 EYNLNPGLEWEDE----FTDDEESSLQNLGNGFTSK--------------------------LPP 207
                   :|.||:    .|:.:|...:..|.|..::                          ...
  Fly   172 -------VEEEDDEEAKGTEGDEGEGEGEGEGAAARQEDDEPAHQAAAVSSKKRKLINQFNYCER 229

  Fly   208 GYLTHGLPTVKDVAPAITP------------------LEIKKETE---VKKEVNELSEEQKQM-- 249
            |.||:..|........|.|                  :|...|::   .|||..:..:.:|:.
  Fly   230 GALTYTNPKRNVDTQTIPPPRSQFGANVLQWVIYDSYMENFAESQKDGTKKEERKRGKREKKFRD 294

  Fly   250 -IILSENFQRFVVRAGRVIERALSENV--DIYTDYIGGGDSEEANDERSHARLSLNRVFYDERWS 311
             ..::|...:..::..:::||.:::|:  ||..||....|..:...|.....|.|.:..||:  :
  Fly   295 KSAIAEQLNKKYLKCWQILERMINQNIYDDIAHDYRYWEDPADEFREGEGNLLPLWKFQYDK--T 357

  Fly   312 KNRCITSMDWSTHFPELVVGSYHNNEESPNEPDGVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAK 376
            |...:|.:.::..:.:|....:.:::......:|.:.::..| ..|.|:.:......||......
  Fly   358 KKMNVTDILFNPSYYDLFAVCFGSHDFMKQTNEGYLCLFTVK-NPSFPDYIIQTDCGVMCCDIHP 421

  Fly   377 FNPNLILGGTYSGQIVLWDNRVQKRTPIQRTPLSAAAHTHPVYCLQMV--GTQNAH---NVISIS 436
            ..|.|.:.|.|.|.:.:::.|...:.|:.   :|...:.....|:..:  |...|.   |..|:|
  Fly   422 TYPFLAVIGLYDGNVAVYNLREDCKEPLY---VSRGVNCKHGECVWQIKWGLDMADGEVNFFSVS 483

  Fly   437 SDGKLCSWSL-----------------DMLSQPQDT-LELQQRQSKAIAITSMAFPANEINSLVM 483
            |||::.:|.|                 .::..|..| :.|:...|      .|.|...:....::
  Fly   484 SDGRVFNWILMQNKLWVTTIITLYRENGLVDGPDGTKVTLKSGGS------CMVFHPVDNKIFLV 542

  Fly   484 GSEDGYVYSASRHGLRSGVNEVYERHLGPITGISTHYNQLSPDFGHLFLTSSIDWTIKLWSLKDT 548
            |:|.||:|..|. ...|.....|..|...:..|.  :|:.:   .::|::...||.:|:|.....
  Fly   543 GTECGYIYKCST-AFSSKYLMTYYAHNMSVYRID--FNRFN---SNIFVSCGADWMVKVWEDMRP 601

  Fly   549 KPLYSFEDNSDYVMDVAWSPVHPALFAAVDGSGRLDLW--NLNQDTEVPTASIVVAGAPALNRVS 611
            .||:.| |....|.||.|:|....:||||...|::.::  |:|:...:...::|......|.|:|
  Fly   602 DPLFIF-DLGAAVGDVKWAPYSSTVFAAVTTEGKVHVFDLNVNKYKAICIQAVVPKRKNKLTRLS 665

  Fly   612 WTPSGLHVCIGDEAGKLYVYDVAENL 637
            :......:.:|||.|......::.||
  Fly   666 FNEKLAFIVVGDEKGVTTSLKLSPNL 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sw	NP_477075.2	Dynein_IC2	107..135	CDD:402922	5/27 (19%)
		WD40	316..632	CDD:421866	73/340 (21%)
		WD40 repeat	316..365	CDD:293791	6/48 (13%)
		WD40 repeat	371..409	CDD:293791	7/37 (19%)
		WD40 repeat	418..457	CDD:293791	13/61 (21%)
		WD40 repeat	469..555	CDD:293791	20/85 (24%)
		WD40 repeat	561..599	CDD:293791	12/39 (31%)
		WD40 repeat	607..633	CDD:293791	7/25 (28%)
CG9313	NP_001286657.1	WD40	<353..706	CDD:225201	78/358 (22%)
		WD40 repeat	362..412	CDD:293791	6/50 (12%)
		WD40	413..640	CDD:295369	57/242 (24%)
		WD40 repeat	415..454	CDD:293791	9/41 (22%)
		WD40 repeat	463..505	CDD:293791	10/41 (24%)
		WD40 repeat	513..557	CDD:293791	12/50 (24%)
		WD40 repeat	571..608	CDD:293791	10/42 (24%)
		WD40 repeat	613..654	CDD:293791	12/40 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45435256
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR12442
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840