DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sw and Dync2i1

DIOPT Version :9

Sequence 1:	NP_477075.2	Gene:	sw / 44160	FlyBaseID:	FBgn0003654	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	XP_006240750.1	Gene:	Dync2i1 / 314523	RGDID:	1306493	Length:	1037	Species:	Rattus norvegicus

Alignment Length:	861	Identity:	151/861 - (17%)
Similarity:	276/861 - (32%)	Gaps:	292/861 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RKAELERKKAKLAALREEKDRRRREK-------EIKDMEEAAGRIGGGAGIDKDQRKD------- 53
            :.|:.|||..:.::.||:|||..:||       ||:|..... |...|...|:::|:.
  Rat   260 KDADRERKHREKSSTREKKDRHSKEKGSSLSDREIEDRHREK-RHKDGLHYDEERRRSHADKKER 323

  Fly    54 -------------------------LDEMLSSL-------------------------------- 61
                                     .||.|.:|
  Rat   324 SLKEEHRKRESKEPEKEDNGLEATGADEYLPNLEDDFVDYEDDFEVCDGDDDSNNEHEAKEKADE 388

  Fly    62 ----GVAPVSEVLSSLSSVNSMTSDNS-----------NTQTPDASLQ---------------AT 96
                ....:.|:..::|:.|....:.|           ||:.|.|...               ||
  Rat   389 LPLAQKREIQEIQKAISAENERVGELSLKMFQKQGRAENTKEPWADANDSTSRTPVCGIFVDFAT 453

  Fly    97 VNGQSGGKKQPLNLSV--------------YNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLSC 147
            .:.:...:.|.|....              :.....::||
  Rat   454 ASHRQKSRSQALKQKTRSTKLLRLIDLDFSFTFSLLDLPP------------------------- 493

  Fly   148 HSSPLSGYMEDWWRPRKAHATDYYDEYNLNPGLEWEDEFTDDEESSLQNLGNGFTSKLPPGYLTH 212
             .:....|:.::.:.....|...|:|.|:...::.||  .:..|...|:.|.        |.:..
  Rat   494 -VNEYDMYIRNFGKKNTKQAYVQYNEDNVERDIQTED--IETREVWTQHPGE--------GTVVS 547

  Fly   213 GLPTVKD-----VAPAI-TPLEIKKETEVKKEVNELSEEQKQMIILSENFQRFVVRAGRVIERAL 271
            |....||     |.|.| ||                            ....|:..|.:|:...|
  Rat   548 GGSEEKDFSDVTVVPKIDTP----------------------------RLSNFLRAACQVVAVLL 584

  Fly   272 SENVDIYTDYIGGGDS-------EEANDERSHARLSLNRVFYDERWSKNRCITSMDWSTHFPELV 329
            .|      |.:..|.|       :..|...|.::|:.:..|...|  |..|:    .::......
  Rat   585 EE------DRLAAGPSWIPRAQDKALNISDSSSQLNTSLPFLQSR--KVSCL----HASRVQRQT 637

  Fly   330 VGSYHNNEESPNEPD----GVVMVWNTKFKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQ 390
            |.|.|:..|....|.    .::.||:. ::.|.|:.|..|:|.|...||:.....|:..||..|.
  Rat   638 VVSVHDLPEKAFAPSLDSRHLLCVWDI-WQPSGPQKVLICESKVTCCCFSPLKAFLLFAGTVHGS 701

  Fly   391 IVLWDNR-------------------------------VQKRTPIQR-TPLSAAAHTHPVYCLQM 423
            :|:||.|                               |..|:|:|. .|::.:|:....:.|..
  Rat   702 VVVWDLREDSRIHHYVRLSSCFWAFRTPTFSTDGILTSVNHRSPLQAIEPVATSAYKKQSFVLSP 766

  Fly   424 VGTQN-----AHNVISISSDGKLCSW------SLDMLSQPQDTLELQQRQSKAIAIT-------- 469
            ..||.     :.::.|:...|.|..|      ..|:.....|...:...:.|.:..|
  Rat   767 FSTQEEMAGLSFHIASLDESGVLNVWVVVELPKADISGSMSDLGLIPGGRIKLVHSTVIQLGHSL 831

  Fly   470 --------------SMAFPANEINSLVMGSEDGYVYSASRHGLRSGVNEVYERHLGPITGISTHY 520
                          |:.|..::.|..|:|::.|.:..::|...|.. .:|::.....:..|..:.
  Rat   832 SHKDGELWGSTQTLSVKFLPSDPNHFVVGTDMGLISHSTRQDWRVS-PKVFKPQQHGVRPIKVNV 895

  Fly   521 NQLSPDFGHLFLTSSIDWTIKLWSLKDTKPLYSFEDNSD--YVMDVAWSPVHPALFAAVDGSGRL 583
            ...||....:||....|.:|:|..|...:|:..:::::.  .|..:.|||..||:|...|.:.|:
  Rat   896 IDFSPFEETVFLAGCSDGSIRLHQLTSERPIMQWDNSTSGRSVTSLQWSPTRPAVFLVQDDASRI 960

  Fly   584 DLWNLNQDTEVPTA----------SIVVAGAPALNRVSWTPSGLHVCIGDEAGKLYVYDVAENLA 638
            .:|:|.::...|.|          ::.:.|.|.....|:    :.:.:...:|.:.:.::.....
  Rat   961 YVWDLLENDLGPVAQQPISPDKLVAMTIVGEPEKTSGSF----VALVLARTSGTVDIQNLKRRWT 1021

  Fly   639 QPSRDEWSRFNTHLSE 654
            .|:.||.|:.:..|.:
  Rat  1022 TPAADEHSQLHLLLQK 1037

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sw	NP_477075.2	Dynein_IC2	107..135	CDD:402922	3/41 (7%)
		WD40	316..632	CDD:421866	76/396 (19%)
		WD40 repeat	316..365	CDD:293791	10/52 (19%)
		WD40 repeat	371..409	CDD:293791	14/69 (20%)
		WD40 repeat	418..457	CDD:293791	9/49 (18%)
		WD40 repeat	469..555	CDD:293791	20/107 (19%)
		WD40 repeat	561..599	CDD:293791	13/47 (28%)
		WD40 repeat	607..633	CDD:293791	2/25 (8%)
Dync2i1	XP_006240750.1	PRP38_assoc	87..166	CDD:289628
		WD40	608..1004	CDD:225201	81/407 (20%)
		WD40	677..965	CDD:295369	58/288 (20%)
		WD40 repeat	680..709	CDD:293791	10/28 (36%)
		WD40 repeat	714..757	CDD:293791	5/42 (12%)
		WD40 repeat	762..803	CDD:293791	8/40 (20%)
		WD40 repeat	844..885	CDD:293791	9/41 (22%)
		WD40 repeat	893..926	CDD:293791	8/32 (25%)
		WD40 repeat	938..963	CDD:293791	9/24 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810