Protein Alignment sw and Dnai4

DIOPT Version :10

• Sequence 1: NP_477075.2
• Gene: sw / 44160
• FlyBaseID: FBgn0003654
• Length: 663
• Species: Drosophila melanogaster
• Sequence 2: XP_036020022.1
• Gene: Dnai4 / 242584
• MGIID: 2385328
• Length: 812
• Species: Mus musculus
• Alignment Length: 712
• Identity: 155/712 - (21%)
• Similarity: 267/712 - (37%)
• Gaps: 181/712 - (25%)

  Fly    59 SSLGVAPVSEVLSSLSSVNSMTSDNSNTQ---------TPDASLQATVNGQSGGKKQPLN----- 109
            |.||.:.||:  ||:|:..||:.|..::.         |....|::|  .::...|:.|.
Mouse   138 SVLGSSSVSK--SSISTTESMSEDLEDSSYKRDRLASFTDVRVLRST--AEAAISKEELEKTIEI 198

  Fly   110 -----------------LSVYNVQATNIPPK----ETL--------VYTKQTQTTSTGGGNGDVL 145
                             .|..:.:|..|..|    |||        :|.::...|..|......:
Mouse   199 ILTETETLRFFDLPTVMFSTESEEAEKIIEKNKKYETLCRNRLGNDLYVERMMQTFNGAPKNKEV 263

  Fly   146 SCHSSPL--SGYMEDWWRPRKAHATDYYDEYNLNPGLEWEDEFTDDEESSLQNLGNGFTSKLPPG 208
            .|....|  .|.:...|        |.||.||:             .|:.|....:|::||
Mouse   264 QCEKIILEEKGVVATTW--------DLYDSYNI-------------PETLLAAKRSGYSSK---- 303

  Fly   209 YLTHGLPTVKDVAPAITPLEIKK----ETEVKKEVNELSEEQKQMIILSENFQRFVVRAGRVIER 269
                |....||..|.|...|...    |..:..:|.|..|:..:.|:.|:...:.:.    .:||
Mouse   304 ----GSLPAKDRDPKIQDSESSSLMDIENVILAKVQEDEEDNSEAILKSDKLHQDLF----YMER 360

  Fly   270 ALSENV-----------DIYTDY-------------IGGGDSEEANDERSHARLSLNRVFYDER- 309
            .|.|||           .:|.::             :...:.|...::.....:.|......|:
Mouse   361 VLMENVFQPKLAAYRQLPVYKEHEPEEPEETLQVENLKVAEDEPKKEDEEEVEMELELEIATEQS 425

  Fly   310 ---------WS------KNRCITSMDWSTHFPELVVGSYHN---NEESPNEPDGVVMVWNTKFKK 356
                     ||      |...::|:.|:...|:|:...|.|   .|:.    .|:...|:.| ..
Mouse   426 TIPANLERLWSFSCDLTKGLNVSSLSWNKANPDLLAVGYGNFGFREQK----KGMACCWSIK-NP 485

  Fly   357 STPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKRTPIQRTPLSAAAHTHPVYCL 421
            ..||.::.....|.|..|:..:|||:..|.::|.:.:::.:.....|:..:..|...|..||:.:
Mouse   486 MWPERIYQSSYGVTSVDFSNSSPNLLAVGYHNGTVAIYNVQSSHNIPVLDSSESPQKHLGPVWQV 550

  Fly   422 QMV-------GTQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQ-----------QRQSKAIAI 468
            |.:       |......::|||:||::..|.:.......|.:.|:           :::.|..|:
Mouse   551 QWIEQDRGTTGDDKREILVSISADGRISKWIIRKGLDCHDLMRLKRTTATGGKKGGEKEKKGEAL 615

  Fly   469 TS-------MAFPANEINSLVMGSEDGYVYSASRHGLRSGVN----EVYERHLGPITGISTHYNQ 522
            .|       .||...:.|..:.|:|:|.::..|     ...|    |.|..|.||:..::  :|.
Mouse   616 ISRQAPGMCFAFHPKDTNIYLAGTEEGLIHKCS-----CSYNEQYLETYRGHKGPVYKVT--WNP 673

  Fly   523 LSPDFGHLFLTSSIDWTIKLWSLKDTKPLYSFEDNSDYVMDVAWSPVHPALFAAVDGSGRLDLWN 587
            ..||   :||:.|.||.:.:|.....||..||...:..|.||:|||....:|||.: ..|:::|:
Mouse   674 FCPD---VFLSCSADWGVMIWHQDTVKPFLSFYPTTYVVYDVSWSPKSAYIFAAAN-ENRVEIWD 734

  Fly   588 LNQDTEVPTASIVVAGAPAL--NRVSWTPSGLHVCIGDEAGKLYVYDVAENLAQPSRDEWSR 647
            |...|..|.  ||....|.:  ..|.:......:.:||..|::.||::..   .|:..:.||
Mouse   735 LQISTLDPL--IVNVANPGIKFTTVLFAKETDCLLVGDSDGQVAVYELRN---MPTASDTSR 791

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
sw	NP_477075.2	Dynein_IC2	105..135	CDD:463291	10/63 (16%)
		WD40	316..632	CDD:475233	86/349 (25%)
		WD40 repeat	316..365	CDD:293791	12/51 (24%)
		WD40 repeat	371..409	CDD:293791	8/37 (22%)
		WD40 repeat	418..457	CDD:293791	10/45 (22%)
		WD40 repeat	469..555	CDD:293791	26/96 (27%)
		WD40 repeat	561..599	CDD:293791	14/37 (38%)
		WD40 repeat	607..633	CDD:293791	6/27 (22%)
Dnai4	XP_036020022.1	WD40 repeat	448..493	CDD:293791	12/49 (24%)
		WD40	<480..782	CDD:441893	79/315 (25%)
		WD40 repeat	498..542	CDD:293791	10/43 (23%)
		WD40 repeat	548..617	CDD:293791	12/68 (18%)
		WD40 repeat	622..660	CDD:293791	9/42 (21%)
		WD40 repeat	667..702	CDD:293791	11/39 (28%)
		WD40 repeat	709..741	CDD:293791	13/32 (41%)
		WD40 repeat	751..780	CDD:293791	6/28 (21%)