DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment sw and Dync2i1

DIOPT Version :9

Sequence 1:	NP_477075.2	Gene:	sw / 44160	FlyBaseID:	FBgn0003654	Length:	663	Species:	Drosophila melanogaster
Sequence 2:	XP_006515843.1	Gene:	Dync2i1 / 217935	MGIID:	2445085	Length:	1033	Species:	Mus musculus

Alignment Length:	833	Identity:	158/833 - (18%)
Similarity:	296/833 - (35%)	Gaps:	236/833 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RKAELERKKAKLAALREEKDRRRREK-------EIKDMEEAAGRIGG--------GAGIDKDQR- 51
            :.|:.|::..:.:::||:::|..|||       |::|.........|        .:..||.:|
Mouse   256 KDADREKRLREKSSMREKRERHAREKGSSLSDREVEDRHREKRHKEGLHYDDERRRSHADKKERS 320

  Fly    52 ----------KDLDEMLSSLGVAPVSEVLSSLS----------SVNSMTSDNSN--------TQT 88
                      |:|::..:.|......|.|.:|.          .|.....|::|        .:.
Mouse   321 SKEEHKKRELKELEKEDNDLEATGPDEYLPNLEDDFVDYEDDFEVCDGDDDSNNEHEAREKAEEL 385

  Fly    89 PDA------SLQATVNGQSGGKKQPLNLSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLSC 147
            |.|      .:|..::.:: .:...|:|.::..|...       .|||:..|.:..       |.
Mouse   386 PLAQKREIQEIQKAISAEN-ERVGELSLKMFQKQGWT-------EYTKEPWTDAND-------SP 435

  Fly   148 HSSPLSGYMEDWWRPRKAHATDYYDEYNLNPGLEWEDEFTDDEESSLQNLGNGFTSKLPPGYLTH 212
            ..:|:.|...|:       ||..:.:.:.:..|  :.:....:...|.:|...||..|      .
Mouse   436 SRTPVCGIFVDF-------ATASHRQKSRSQAL--KQKTRSSKLLRLIDLDFSFTFSL------L 485

  Fly   213 GLPTVKDVAPAITPLEIKKETEVKKEVNELSEEQKQMIILSENFQRFVVRAGRVIERALSENVDI 277
            .||.|.:....|.... ||.|  |:...:.:|:..:..|.:|:.                |..::
Mouse   486 DLPPVNEYDMYIRNFG-KKNT--KQAYVQYNEDNVERDIQTEDI----------------ETREV 531

  Fly   278 YTDYIG-----GGDSEE-----------------ANDERSHAR-----LSLNRVFYDERW---SK 312
            :|.:.|     .|.|||                 ||..|:..:     |..:|:.....|   ::
Mouse   532 WTQHPGEGTAVSGGSEEKDFSDVTVVPKIDTPRLANFLRAACQVVAVLLEEDRLAAGPSWIPRAQ 596

  Fly   313 NRCITSMDWS----THFPEL----------------VVGSYHNNEESPNEPD----GVVMVWNTK 353
            ::.:...|.|    |..|.|                .|.|.|:..|....|.    .::.||:.
Mouse   597 DKALNISDSSSQLNTSLPFLQSRKVSCLHASRVQRQTVVSVHDLPEKAFAPSLDSRHLLCVWDI- 660

  Fly   354 FKKSTPEDVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNR--------------------- 397
            ::.|.|:.|..|:|.|...||:.....|:..||..|.:|:||.|
Mouse   661 WQPSGPQKVLICESKVTCCCFSPLKAFLLFAGTVHGSVVVWDLREDSRIHHYVRLSNCFWAFRTP 725

  Fly   398 ----------VQKRTPIQR-TPLSAAAHTHPVYCLQMVGTQN-----AHNVISISSDGKLCSW-- 444
                      |..|:|:|. .|::.:|:....:.|....||.     :.::.|:...|.|..|
Mouse   726 TFSTDGILTSVNHRSPLQAIEPVATSAYKKQSFVLSPFSTQEEMAGLSFHIASLDETGVLNVWVV 790

  Fly   445 ----SLDMLSQPQD--------------TL-----ELQQRQSKAIAIT---SMAFPANEINSLVM 483
                ..|:.....|              |:     .|..:.|:....|   |:.|..::.|..|:
Mouse   791 VELPKADISGSMSDLGLIPGGRIKLVHSTVIQLGNSLSHKDSELWGSTQTLSVKFLPSDPNHFVV 855

  Fly   484 GSEDGYVYSASRHGLRSGVNEVYERHLGPITGISTHYNQLSPDFGHLFLTSSIDWTIKLWSLKDT 548
            |::.|.:..::|...|.. ..|::.....:..|..:....||....:||....|.:|:|..|...
Mouse   856 GTDMGLISHSTRQDWRVS-PRVFKPEQHGVRPIKVNVIDFSPFEETVFLAGCSDGSIRLHQLTSE 919

  Fly   549 KPLYSFEDNSD--YVMDVAWSPVHPALFAAVDGSGRLDLWNLNQDTEVPTA----------SIVV 601
            :|:..:::::.  .|..:.|||..||:|...|.:.|:.:|:|.::...|.|          ::.:
Mouse   920 RPIMQWDNSTSGHAVTSLQWSPTRPAVFLVQDDASRIYVWDLLENDLGPVAQQPISPDKLVAMTI 984

  Fly   602 AGAPALNRVSWTPSGLHVCIGDEAGKLYVYDVAENLAQPSRDEWSRFNTHLSE 654
            .|.|.....|:    :.:.:...:|.:.|.::......|:.||.|:....|.:
Mouse   985 VGEPEKTSGSF----VALVLARTSGTVDVQNLKRRWTTPAVDEHSQLRLLLQK 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
sw	NP_477075.2	Dynein_IC2	107..135	CDD:402922	6/27 (22%)
		WD40	316..632	CDD:421866	84/416 (20%)
		WD40 repeat	316..365	CDD:293791	15/72 (21%)
		WD40 repeat	371..409	CDD:293791	14/69 (20%)
		WD40 repeat	418..457	CDD:293791	10/68 (15%)
		WD40 repeat	469..555	CDD:293791	20/88 (23%)
		WD40 repeat	561..599	CDD:293791	13/47 (28%)
		WD40 repeat	607..633	CDD:293791	3/25 (12%)
Dync2i1	XP_006515843.1	PTZ00121	<48..396	CDD:173412	25/139 (18%)
		WD40	604..1000	CDD:225201	82/401 (20%)
		WD40 repeat	635..671	CDD:293791	9/36 (25%)
		WD40 repeat	676..708	CDD:293791	11/31 (35%)
		WD40 repeat	715..752	CDD:293791	5/36 (14%)
		WD40 repeat	759..788	CDD:293791	6/28 (21%)
		WD40 repeat	842..878	CDD:293791	9/36 (25%)
		WD40 repeat	890..926	CDD:293791	9/35 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1587
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810