DRSC/TRiP Functional Genomics Resources

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Protein Alignment sw and DYNC1I2

DIOPT Version :9

Sequence 1:NP_477075.2 Gene:sw / 44160 FlyBaseID:FBgn0003654 Length:663 Species:Drosophila melanogaster
Sequence 2:NP_001258714.1 Gene:DYNC1I2 / 1781 HGNCID:2964 Length:638 Species:Homo sapiens


Alignment Length:691 Identity:327/691 - (47%)
Similarity:443/691 - (64%) Gaps:104/691 - (15%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 KAELERKKAKLAALREEKDRR---RREKEIKDMEEAAGRIGGGAGIDKDQRKDLDEMLSSLGVAP 65
            ||||||||.:||.:||||.|:   |::||....:||...:...:.::| :|::.:.:|.|:|:.|
Human     8 KAELERKKQRLAQIREEKKRKEEERKKKETDQKKEAVAPVQEESDLEK-KRREAEALLQSMGLTP 71

  Fly    66 VSEVLSSLSSV-NSMTSDNSNTQTP-DASLQATVNGQSGGK--------------------KQPL 108
            .|.::.|...| ..|:..:.:..|| :|..|.:.:|..|.:                    :.|:
Human    72 ESPIVFSEYWVPPPMSPSSKSVSTPSEAGSQDSGDGAVGSRTLHWDTDPSVLQLHSDSDLGRGPI 136

  Fly   109 NLSVYNVQATNIPPKETLVYTKQTQTTSTGGGNGDVLSCHSSPLSGYMEDWWRPRKAHATDYYDE 173
            .|.:..:...:.||:|.:.|||:|||                |:..      :|:          
Human   137 KLGMAKITQVDFPPREIVTYTKETQT----------------PVMA------QPK---------- 169

  Fly   174 YNLNPGLEWEDEFTDDEESSLQNLGNGFTSKLPPGYLTHGLPTVKDVAPAITPLEIKKETEVKKE 238
                     |||..||                             ||.....|:|.::|..:||:
Human   170 ---------EDEEEDD-----------------------------DVVAPKPPIEPEEEKTLKKD 196

  Fly   239 --------VNELSEEQKQMIILSENFQRFVVRAGRVIERALSENVDIYTDYIGGGDSEEANDERS 295
                    .:||:||:||.|:.||.|..|...:.|::||||||.::|:.||.|....::..:.::
Human   197 EENDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQINIFFDYSGRDLEDKEGEIQA 261

  Fly   296 HARLSLNRVFYDERWSKNRCITSMDWSTHFPELVVGSYHNNEESPNEPDGVVMVWNTKFKKSTPE 360
            .|:|||||.|:||||||:|.::.:|||:.:|||:|.||:|||::|:|||||.:|||.|:||:|||
Human   262 GAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPE 326

  Fly   361 DVFHCQSAVMSTCFAKFNPNLILGGTYSGQIVLWDNRVQKRTPIQRTPLSAAAHTHPVYCLQMVG 425
            .||||||||||..||||:|||::||||||||||||||..||||:||||||||||||||||:.:||
Human   327 YVFHCQSAVMSATFAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVG 391

  Fly   426 TQNAHNVISISSDGKLCSWSLDMLSQPQDTLELQQRQSKAIAITSMAFPANEINSLVMGSEDGYV 490
            ||||||:||||:|||:|||||||||.|||::||..:||||:|:|||:||..::|:.|:|||:|.|
Human   392 TQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQSKAVAVTSMSFPVGDVNNFVVGSEEGSV 456

  Fly   491 YSASRHGLRSGVNEVYERHLGPITGISTHYNQLSPDFGHLFLTSSIDWTIKLWSLKDTKPLYSFE 555
            |:|.|||.::|::|::|.|.||||||..|....:.||.|||:|||.|||:|||:.|:.|||||||
Human   457 YTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYSFE 521

  Fly   556 DNSDYVMDVAWSPVHPALFAAVDGSGRLDLWNLNQDTEVPTASIVVAGAPALNRVSWTPSGLHVC 620
            ||:|||.||.|||.||||||.|||.|||||||||.|||||||||.|.|.||||||.||.||..:.
Human   522 DNADYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIA 586

  Fly   621 IGDEAGKLYVYDVAENLAQPSRDEWSRFNTHLSEIKMNQSD 661
            :||..|::.:|||.|.:|.|..|||:||...|:||..|::|
Human   587 VGDSEGQIVIYDVGEQIAVPRNDEWARFGRTLAEINANRAD 627

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
swNP_477075.2 Dynein_IC2 107..135 CDD:402922 10/27 (37%)
WD40 316..632 CDD:421866 214/315 (68%)
WD40 repeat 316..365 CDD:293791 29/48 (60%)
WD40 repeat 371..409 CDD:293791 29/37 (78%)
WD40 repeat 418..457 CDD:293791 30/38 (79%)
WD40 repeat 469..555 CDD:293791 48/85 (56%)
WD40 repeat 561..599 CDD:293791 31/37 (84%)
WD40 repeat 607..633 CDD:293791 12/25 (48%)
DYNC1I2NP_001258714.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..135 36/127 (28%)
Dynein_IC2 135..163 CDD:402922 11/43 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 155..214 24/128 (19%)
WD 1 277..326 28/48 (58%)
WD40 repeat 282..331 CDD:293791 29/48 (60%)
WD40 329..>599 CDD:225201 187/269 (70%)
WD 2 330..370 32/39 (82%)
WD40 repeat 339..377 CDD:293791 30/37 (81%)
WD 3 379..420 33/40 (83%)
WD40 repeat 385..426 CDD:293791 31/40 (78%)
WD 4 429..469 22/39 (56%)
WD40 repeat 434..481 CDD:293791 24/46 (52%)
WD 5 474..519 26/44 (59%)
WD40 repeat 489..521 CDD:293791 20/31 (65%)
WD 6 522..562 32/39 (82%)
WD40 repeat 527..565 CDD:293791 31/37 (84%)
WD 7 568..607 19/38 (50%)
WD40 repeat 573..599 CDD:293791 12/25 (48%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165140647
Domainoid 1 1.000 377 1.000 Domainoid score I864
eggNOG 1 0.900 - - E1_KOG1587
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 600 1.000 Inparanoid score I957
Isobase 1 0.950 - 0 Normalized mean entropy S2725
OMA 1 1.010 - - QHG54336
OrthoDB 1 1.010 - - D1453532at2759
OrthoFinder 1 1.000 - - FOG0001314
OrthoInspector 1 1.000 - - mtm8531
orthoMCL 1 0.900 - - OOG6_101571
Panther 1 1.100 - - LDO PTHR12442
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R314
SonicParanoid 1 1.000 - - X812
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1615.750

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